Synthetic Route of 71759-87-0, These common heterocyclic compound, 71759-87-0, name is 4-Iodo-1-methyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 64.3 (0.400g, 1.23mmol, 1.Oeq) 4-iodo- 1-methyl-1H-imidazole (0.306g, 1.47mmol, 1.2eq) in mixture of MeOH (4mL) and dimethoxymethane (lmL). The reaction mixture was degassed by argon for 30 mm. Tetrakis(triphenylphosphine)palladium (0.141 g, 0.1 22mmol, 0.1 eq), Cesium fluoride (0.61 Og, 4.O4mmol, 3.3eq,) was added into reaction mixture and again reaction mixture was degassed by argon for 30 mm. Further reaction mixture was stirred at 150C for 5h. After completion of reaction, water was added to reaction mixture and extracted with ethyl acetate. Organic layers were combined, dried over Na2SO4 and concentrated in vacuo to obtain crude product. This was purified by column chromatography and compound was eluted in 20% ethyl acetate in hexane to obtain64.4 (0.200g, 58.18 %). MS(ES): m/z 281.35 [M+H]t
The synthetic route of 71759-87-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (869 pag.)WO2018/75937; (2018); A1;,
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