In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 53710-78-4 as follows. HPLC of Formula: C6H9ClN2
EXAMPLE 23 A mixture of 4-(3′-chloro-4′-fluoroanilino)-6-hydroxy-7-methoxyquinazoline (1.5 g), 3-(imidazol-1-yl)propyl chloride (0.67 g), potassium carbonate (3 g) and DMF (40 ml) was stirred and heated to 90 C. for 1 hour. A second portion (0.12 g) of the propyl chloride was added and the mixture was heated to 90 C. for a further hour. The mixture was cooled to ambient temperature, filtered and evaporated. The residue was purified by column chromatography using a 9:1 mixture of methylene chloride and methanol as eluent. There was thus obtained 4-(3′-chloro-4′-fluoroanilino)-6-(3-imidazol-1 -ylpropoxy)-7-methoxyquinazoline (0.66 g); NMR Spectrum: 2.5 (m, 2H), 4.12 (s, 3H), 4.25 (t, 2H), 4.35 (t, 2H), 7.08 (s, 1H), 7.4 (d, 2H), 7.6 (t, 1H), 7.8 (s, 1H), 7.95 (m, 2H), 8.25 (m, 1H), 8.65 (s, 1H), 9.7 (broad s, 1H); Elemental Analysis: Found C, 58.2; H, 4.6; N, 16.6; C21 H19 ClFN5 O2 0.2H2 O requires C, 58.5; H, 4.5; N, 16.2%.
According to the analysis of related databases, 53710-78-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Zeneca Limited; US5770599; (1998); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem