In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 616-47-7 as follows. Quality Control of 1-Methyl-1H-imidazole
In a 100-mL round bottom flask, a mixture of 1-methyl imidazole (0.1 mol, 8.21 g) and 1,4-butane sultone (0.1 mol, 11 mL) in toluene (30 mL) was refluxed for 24 h. The obtained white solid was washed with toluene (2910 mL) and dried under reduced pressure. Then, a stoichiometric amount of concentrated sulfuric acid (98 %) was added to the solid and the mixture was stirred for 24 h at 70 C to form the DAIL. It was then washed with diethyl ether (2*10 mL) and dried under vacuum.
According to the analysis of related databases, 616-47-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Rostamizadeh, Shahnaz; Zekri, Negar; Research on Chemical Intermediates; vol. 42; 3; (2016); p. 2329 – 2341;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem