Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid, A new synthetic method of this compound is introduced below., COA of Formula: C8H6N2O2
To a stirred solution of compound 189 (24 g, 148 mmol) in DCM (250 mL) under inert atmosphere, DIPEA (51.58 mL, 296 mmol) and HATU (84.39g, 222 mmol) were added. To this solution, N,O-dimethylhydroxylamine hydrochloride (21.66 g, 222 mmol) was added and stirred at room temperature for 16 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was poured into ice-cold water and extracted using DCM. The combined organic extracts were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to obtain the crude. The crude was purified through silica gel column chromatography using 50% EtOAc/ hexanes to afford compound 190 (15 g, 49.40%) as a white solid. TLC: 5% MeOH/ DCM (Rf: 0.5); 1H NMR (400 MHz, DMSO-d6): delta 13.19 (s, 1H), 7.84 (d, J=8.4 Hz, 1H), 7.54 (d, J=7.6 Hz, 1H), 7.34- 7.24 (m, 2H), 3.83 (s, 6H); LCMS Calculated for C10H11N3O2: 205.09; Observed: 206 (M+1)+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ASSEMBLY BIOSCIENCES, INC.; TURNER, William, W., Jr.; LI, Leping; HAYDAR, Simon, Nicolas; BURES, Mark, G.; RAI, Roopa; FRANCIS, Samson; ARNOLD, Lee, Daniel; (0 pag.)WO2018/160878; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem