The synthetic route of 4-Amino-1H-imidazole-5-carboxamide has been constantly updated, and we look forward to future research findings.
Electric Literature of 360-97-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 360-97-4, name is 4-Amino-1H-imidazole-5-carboxamide belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A solution of 5-amino-1 H-imidazole-4-carboxamide (0.6 g, 4.7 mmol), toluene- 4-sulfonic acid butyl ester previously prepared (cf. Sekera, V. et al., “Higher alkyl sulfonates”, J. Am. Chem. Soalpha, 1993, vol. 55, p. 345) (1.3 g, 5.7 mmol), and Cs2CO3 (1.5 g, 4.7 mmol) in 25 ml_ of DMF was stirred at 8O0C for 16 h. Removal of the solvent and purification by chromatography on silica (CHCI3/MeOH, 5%) yielded delta-amino-i -butyl-I H-imidazole^-carboxamide (0.5 g, 62%) as a viscous oil . 1H-NMR [CDCI3, delta, ppm]: 8.1 (s, 1 H), 3.79 (m, 2H, CH2N), 1.54 (m, 2H, CH2), 1.37 (m, 2H, CH2), .0.92 (m, 3H, CH3).
The synthetic route of 4-Amino-1H-imidazole-5-carboxamide has been constantly updated, and we look forward to future research findings.