616-47-7, name is 1-Methyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-Methyl-1H-imidazole
After replacing the inside of a 100 mL three-necked flask with an argon atmosphere, 22 mL of acetonitrile and 6.3 mL of methyl chloroformate were added and the mixture was cooled to -20 C. To this solution, a solution of 3.3 g of 1-methyl-1H-imidazole and 6.8 mL of triethylamine in 8 mL of acetonitrile was added in 30 minutes, followed by stirring at room temperature for 12 hours. After adding 50 mL of ethyl acetate to the reaction solution, insoluble matter was filtered off, and the residue was washed with 50 mL of ethyl acetate. The filtrate and the washing solution were combined, concentrated under reduced pressure,the concentrated residue was purified by column chromatography(Silica gel, hexane / ethyl acetate) to obtain 4.2 g (yield: 73%) of methyl 1-methyl-1H-imidazole-2-carboxylate.
The synthetic route of 616-47-7 has been constantly updated, and we look forward to future research findings.