Related Products of 934-22-5, These common heterocyclic compound, 934-22-5, name is 6-Aminobenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a vessel charged with N-(2-(1H-indol-3-yl)ethyl)-2-chloroquinazolin-4-amine (8a, 232 mg, 0.72 mmol)was added ethanol (5 mL), hydrochloric acid (10 mL), and 1Hindazol-5-amine (96 mg, 0.72 mmol). The vessel was sealed andstirred for 6 h at 120 C. The resulting mixture was dried underreduced pressure and subjected to silica gel column chromatographyusing dichloromethane/methanol (90:10) as the mobilephase to afford the desired compound 9a as a white solid (184 mg,0.87 mmol, 61% yield).
The synthetic route of 934-22-5 has been constantly updated, and we look forward to future research findings.