These common heterocyclic compound, 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 870837-18-6
Synthesis of (Z)-(S)-4-[(1R,2R)-2-hydroxy-1-(3,4,5-trifluorophenyl)propyl]-2-[1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene]-6-methylmorpholin-3-one A solution of (S)-4-[(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propyl]-2-hydroxy-6-methylmorpholin-3-one (92 mg) and triphenylphosphine hydrobromide (68 mg) in acetonitrile (4 ml) was heated under reflux in a nitrogen atmosphere for one hour. The solvent was evaporated under reduced pressure, and the resulting residue was dissolved in ethanol (4 ml). To this reaction solution, 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde obtained in Example 1 (40 mg) and TEA (0.12 ml) were added, and the reaction solution was stirred in a nitrogen atmosphere at room temperature overnight. The solvent was evaporated under reduced pressure. The resulting residue was dissolved in trifluoroacetic acid (1 ml), and the reaction solution was stirred at room temperature for two hours. The reaction solution is poured into a saturated sodium bicarbonate solution, followed by extraction with ethyl acetate. The organic layer was washed with a saturated sodium bicarbonate solution and brine, and then the solvent was evaporated under reduced pressure. The resulting residue was purified by column chromatography using NH silica gel (heptane:ethyl acetate=1:1 to 0:1) to obtain 61.9 mg of the title compound. 1H-NMR(CDCl3) delta (ppm): 1.33(d,J=6.0 Hz,3H), 1.42(d,J=6.0 Hz,3H), 2.34(s,3H), 3.20(dd,J=9.6,12.8 Hz,1H), 3.61(dd,J=2.4,12.8 Hz,1H), 3.85(s,3H), 4.42-4.52(m,2H), 5.35(d,J=6.8 Hz,1H), 6.85(s,1H), 6.95(s,1H), 7.06-7.15(m,2H), 7.22(d,J=8.0 Hz, 1H), 7.33(dd,J=1.6,8.0 Hz,1H), 7.53(d,J=1.6 Hz,1H), 7.86(s,1H).
The synthetic route of 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde has been constantly updated, and we look forward to future research findings.