Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-32-4, name is 1H-Imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H4N2
Imidazole (10 g, 0.150 mol) and sodium hydroxide (29.4 g, 0.74 mol) were charged to the reaction flask containing water (250 mL) and stirred vigorously for 15 min at ambient temperature. Cooled the reaction mass to 10 C and charged sodium hypochlorite (16.7 g, 0.225 mol) to the reaction mixture, during the addition temperature was maintained at 10 C. Stirred the reaction mass for 6 h at ambient temperature, the reaction completion was monitored by TLC. After the completion of the reaction cooled the reaction mass to 10 C and slowly charged concentrated HCl solution to bring the reaction pH to 6 to 7. Charged dichloromethane (2 * 200 mL) and stirred for 10 min, separated the organic layer and was washed with saturated brine solution. The organic layer was dried over sodium sulfate and concentrated the dichloromethane and the crude obtained was purified by column chromatography on a silica gel (230-400 mesh) using ethyl acetate (10-35%) in petroleum ether as eluant to afford 4-chloroimidazole. Appearance: Pale yellow solid; Yield = 52%; M.P. = 118-119 C; 1H NMR (400 MHz, DMSO-d6) delta ppm = 7.09 (s, 1H, ArH), 7.39 (s, 1H, ArH), 12.42 (s, 1H, NH); 13C NMR (300 MHz, DMSO-d6) delta ppm = 126.7, 128.2, 140.2; LC/MS (ESI-MS) m/z = 103.6 (M + 1).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.