Synthetic Route of 13275-42-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13275-42-8 name is 2-(2-Bromophenyl)-1H-benzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a 5mL screw-capped vial was added 1 (0.3mmol) and 1,3-diketone 2 (0.45mmol), together with CuI (0.006g, 0.03mmol), K3PO4 (0.127g, 0.6mmol), and DMF (3mL). The mixture was stirred at 130C for 24h. The mixture was then cooled to room temperature, and filtered through a short column of silica gel (ethyl acetate) to remove inorganic salts. Removal of the solvent left a crude mixture, which was separated by TLC [silica gel 60 GF254 (Merck), ethyl acetate-hexane (the reaction with acyclic ketones) or dichloromethane-methanol (the reaction with cyclic ketones)] to give desired products 3. Except for known 3o [11h], 3q [11c], 3s [11b] and 3t [10a], all new products prepared by the above procedure were characterized spectroscopically as shown below. Similar treatment of 6 with 2a and work-up (TLC, CH2Cl2/MeOH=99/1) shown above gives 7 in 56% yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2-Bromophenyl)-1H-benzo[d]imidazole, and friends who are interested can also refer to it.