Month: April 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75370-65-9, name is 4-Amino-1H-benzo[d]imidazol-2(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H7N3O

Preparation of 1-(2-(dimethylamino)-4-(trifluoromethyl)benzyl)-3-(2,3-dihydro-2-oxo-1H-benzo[d]imidazol-4-yl)urea. Amine 2a (1.3 g, 5.9 mmol) was dissolved in 40 ml of AcOEt and at 0C triphosgene (1.75 g, 5.9 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 5ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound 1a (860 mg, 5.77 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt). The solvent was evaporated and the crude was dissolved in AcOEt (50 ml) and washed with water (1 X 30 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 650mg of a yellow solid. Yield = 28% 1HNMR (DMSO, 200 MHz) delta 2.51 (6H, bs), 4.43 (2H, d, J = 5.6 Hz), 6.62 (1H, dd, J = 7.6 Hz, J’ = 1 Hz), 6.82 (2H, m), 6.97 (1H, dd, J = 8 Hz, J’ = 1 Hz), 7.32 (1H, s), 7.39 (1H, d), 7.49 (1H, d), 8.35 (1H, bs), 9.99 (1H, bs), 10.59 (1H, bs); [M+1] 394.1 (C18H18F3N5O2 requires 393.36).

According to the analysis of related databases, 75370-65-9, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3273-68-5, name is 4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)butanoic acid, This compound has unique chemical properties. The synthetic route is as follows., name: 4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)butanoic acid

Part A. Preparation of chloro 2,3-dihydro-2-oxo-1H-benzimidazol-1-butanoate. Dichloromethane (3772 L) and then 4-(2-oxo-2,3-dihydrobenzimidazol-1-yl)butyric acid (525 kg; 2.4 kmol) were charged to a stirred-tank reactor, followed by N,N-dimethylformamide (21 L). The resulting mixture was cooled to 10 C. Afterward, oxalyl chloride (326.8 kg)) was dosed at 10-15 C. over 2-3 hours while stirring. The resulting mixture was then stirred at 15-20 C. for an additional 1-3 hours. All the above steps were conducted under a N2 atmosphere. Conversion was checked by in-process control (“IPC?).

According to the analysis of related databases, 3273-68-5, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2466-76-4

Nucleoside/nucleotide (2; 100 mM) and N-acetyl imidazole (1a;10 equiv) were dissolved in water (pH 8; adjusted with 4 MNaOH). The solution was incubated at r.t. for 4 h, and NMR spectra were periodically acquired. The product was purified byreverse-phase (C18) flash coumn chromatography (eluted at pH4 with 100 mM NH4HCO2/MeCN = 98:2 to 80:20). The fractions containing 5 were lyophilised to yield a white powder.Selected Data: 2?,3?-Di-O-acetyl-beta-cytidine-5?-phosphate (5a)Starting from 1a (160 mg, 0.50 mmol), 5a (172 mg, 85percent) wasobtained as a white powder. 1H NMR (600 MHz, D2O): delta = 8.08[d, J = 7.9 Hz, 1 H, H-(C6)], 6.22 [d, J = 7.9 Hz, 1 H, H-(C5)], 6.11[d, J = 5.1 Hz, 1 H, H-(C1?)], 5.41 [dd, J = 5.4, 5.1 Hz, 1 H, H-(C2?)],5.38 [dd, J = 5.4, 4.4 Hz, 1 H, H-(C3?)], 4.48 [ddd, J = 4.9, 4.4, 2.4Hz, 1 H, H-(C4?)], 4.13 [ABXY, J = 11.9, 4.4, 2.4 Hz, 1 H, H-(C5?)],4.02 [ABXY, J = 11.9, 4.9, 2.4 Hz, 1 H, H-(C5??)], 2.09 [s, 3 H, Ac-(C3?)], 2.05 [s, 3 H, Ac-(C2?)]. 13C NMR (151 MHz, D2O): delta = 173.4(3?-OAc), 173.1 (2?-OAc), 160.7 (C4), 150.1 (C2), 144.3 (C6), 96.5(C5), 88.2 (C1?), 82.5 (d, C4?), 74.5 (C2?), 71.5 (C3?), 64.4 (d, C5?),20.6 (3?-OAc), 20.5 (2?-OAc). 31P NMR (162 MHz, D2O, 1H-decoupled):delta = 0.30. IR (neat): 1746, 1660, 1489, 1462, 1429, 1375,1075 cm?1. ESI-HRMS: m/z [M + H+] calcd for C13H19N3O10P:408.0803; found: 408.0810.

The synthetic route of 1-(1H-Imidazol-1-yl)ethanone has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 2034-22-2, name is 2,4,5-Tribromoimidazole, molecular formula is C3HBr3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2,4,5-Tribromoimidazole

2,4,5-Tribromo-1H-imidazole (1a) (98.7 g, 324 mmol, 1.0 eq) was dissolved into 1.20 L of DCM and cooled to 0 C. To this was added DIPEA (62 mL, 360 mmol, 1.1 eq) followed by the slow addition of [beta-(trimethylsilyl)ethoxy]methyl chloride (60.2 mL, 340 mmol, 1.05 eq). The solution was slowly warmed to room temperature. After 2 hours the mixture was washed with 1M H3PO4 /saturated aqueous NaCl (1:10 ; 2×600 mL). The organic layer was dried over MgSO4, and evaporated to dryness, yielding intermediate (1b) as faint yellow liquid that solidified on standing (137 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2034-22-2, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 41716-18-1

To a solution of intermediate 72-d.HCl (3.0 g, 4.61 mmol) in DMF cooled to 0° C. were sequentially added 1-N-methylimidazole carboxylic acid (988 mg, 7.83 mmol), HATU (2.98 g, 7.83 mmol) and DIPEA (3.22 mL, 18.43 mmol) and the reaction mixture was stirred at room temperature overnight. Saturated aqueous ammonium chloride and ethyl acetate were added; the organic layer was separated, washed with saturated aqueous NaHCO3 and brine, dried over anhydrous MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography provided intermediate 77-a as white foam.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 41716-18-1.

Electric Literature of 33468-69-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33468-69-8, name is 4-(Trifluoromethyl)-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a mixture of 0.8 g of the intermediate compound 2-3, 0.36 g of 4-(trifluoromethyl)imidazole and toluene were added 0.74 g of potassium carbonate, 0.26 mL of trans-N, N?-dimethylcyclohexane-1,2-diamine and 0.15 g of copper iodide. The reaction mixtures were stirred at 120 C. for 24 hours, and cooled to room temperature, and thereto was added water, and the mixtures were extracted with ethyl acetate. The obtained organic layers were washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to a silica gel column chromatography (hexane:ethyl acetate=3:2) to obtain the compound A-12 of the present invention 0.32 g. (1689) Compound A-12 of the present invention: 1H-NMR (CDCl3) delta: 1.37 (3H, t), 3.41-3.49 (2H, m), 6.49 (1H, d), 6.66 (1H, s), 7.54 (1H, d), 7.70-7.76 (2H, m), 8.04 (1H, s), 8.50 (1H, d), 8.90 (1H, d).

The synthetic route of 4-(Trifluoromethyl)-1H-imidazole has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 1003-21-0, name is 5-Bromo-1-methyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C4H5BrN2

5-Bromo-1-methyl-1H-imidazole (0.5 M in DCM, 1.67 mL, 0.834 mmol) was treated with ethylmagnesium chloride (2.09 M in THF, 0.399 mL, 0.834 mmol) dropwise under argon with stirring at room temperature over 1 minute, and the resulting slurry was stirred at 40 C. for 20 minutes. This was treated rapidly dropwise over 1 minute with a solution of tert-butyl 4-(3-(piperidine-1-carbonyl)-2,4-bis(trifluoromethyl)quinoline-6-carbonyl)piperidine-1-carboxylate (196 mg, 0.334 mmol, Intermediate 3: step f) in THF (1.6 mL) with stirring at room temperature, and was then stirred at 40 C. for 2 hours. The reaction was then quenched at room temperature with 5 M aqueous NH4Cl (1 mL) and extracted with 1:1 THF/heptanes (2*3 mL), and the combined organic layers were dried (Na2SO4), filtered, and concentrated. The residue was purified by FCC (0-10% MeOH in DCM) to provide a ?1:1 mixture of the title compound and tert-butyl 4-(2-(1-methyl-1H-imidazol-5-yl)-3-(piperidine-1-carbonyl)-2,4-bis(trifluoromethyl)-1,2-dihydroquinoline-6-carbonyl)piperidine-1-carboxylate as a beige foam. MS m/e 670.3 [M+H]+.

The synthetic route of 5-Bromo-1-methyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 71759-89-2, name is 5-Iodo-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C3H3IN2

4-iodoimidazole (5.38g, 27.72mmol) was dissolved in THF (86ml_). Trityl chloride, (8.5g, 30.49mmol) and triethylamine (7.73ml_, 55.44mmol) were added and the reaction was heated at 70 C. After 3 h, TLC showed that the reaction had gone to completion. Therefore, the reaction mixture was allowed to cool to 45 C and filtered to remove the suspended white solid. The filtrate was concentrated, redissolved in DCM (300 mL) and washed with 5 wt% aq. sodium thiosulfate solution (300 mL), which was back-extracted with DCM (150 mL). The organics were combined, dried over sodium sulfate, filtered and concentrated to yield the crude product. The white solid was taken up in EtOAc (300ml) and heated to reflux for 30 minutes. The mixture was cooled and the solid was obtained by vacuum filtration. The white solid was dried in the vacuum oven for 3 hours affording 4- iodo-1 -trityl-imidazole (6.721 g, 15.40mmol, 55.57% yield). MS Method 2: RT 2.08 min, ES+ m/z 459 [M+Na]+ H NMR (400MHz, DMSO) delta/ppm: 7.35-7.40 (m, 10H), 7.06-7.1 1 (m, 7H).

The synthetic route of 5-Iodo-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference of 641571-13-3, A common heterocyclic compound, 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, molecular formula is C12H9F3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 6 compound (10 mg, 0.028 mmol), substituted benzoic acid (0.028 mmol), HOBt (6.8 mg, 0.05 mmol), EDCI (8.05 mg, 0.04 mmol) and TEA (10 muL, 0.07 mmol) in DMF (0.5 mL) was stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate and washed with saturated aqueous sodium bicarbonate. The organic layer dried over Na2SO4. Purification of column chromatography with Hexane/ethyl acetate = 1:1 to afford compound 7.

The synthetic route of 641571-13-3 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 16681-59-7, name is 2-Bromo-1-methyl-1H-imidazole, molecular formula is C4H5BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Bromo-1-methyl-1H-imidazole

To a solution of 2-bromo-1-methyl-1H-imidazole (9) (0.10 g, 0.60 mmol) in dry toluene (6 mL), p-anisidine (0.15 g, 1.19mmol), Pd2(dba)3 (51.02 mg, 0.06 mmol), BINAP (0.11 g, 0.18 mmol) and Cs2CO3 (0.39 g, 1.19mmol) were added sequentially, and the resulting mixture was heated at 100 C for 21 h. Thereaction was quenched by the addition of saturated NaHCO3 (5 mL). The organic layer wasseparated and the aqueous phase was extracted with AcOEt (3 × 10 mL). The combined organicextracts were washed with brine (5 mL), dried (Na2SO4) and concentrated in vacuo, to obtain 10(0.11 g, 90 %) as an oil. This product was unstable and could not be further purified by columnchromatography: IR (film): numax 3343 cm-1; 1H NMR (300 MHz) delta 3.44 (broad s, 1H), 3.55 (s,3H), 3.70 (s, 3H), 6.67 (d, J 9.0 Hz, 2H), 6.72 (d, J 9.0 Hz, 2H), 6.92 (d, J 1.4 Hz, 1H), 6.97 (d, J1.4 Hz, 1H); 13C NMR (75.5 MHz) delta 34.3, 55.5, 114.6, 116.1, 119.8, 122.8, 129.5, 139.9, 152.5.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 16681-59-7, its application will become more common.