Month: April 2021

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1457-58-5, name is 2-Methyl-1H-imidazole-5-carboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C5H6N2O2

a) (S)-N-(l -(3 -(3 -chloro-4-cyanophenyl)- 1 H-pyrazol- 1 -yl)propan-2-yl)-2- methyl- 1 H-imidazole-4-carboxamide2-Methyl-lH-imidazole-4-carboxylic acid (29.0 g, 230 mmol), 335 ml of DMF and 165 ml of DCM were placed in to the reaction vessel under nitrogen.HBTU (7.27 g, 19.18 mmol), EDCI (44.1 g, 230 mmol) and 66.8 ml of DIPEA were added. (S)-4-(l-(2-aminopropyl)-lH-pyrazol-3-yl)-2-chlorobenzonitrile (50 g, 192 mmol) was added and the reaction stirred overnight at RT. 600 ml of water was slowly added and water phase was washed with 335 ml and 500 ml of DCM. DCM phases were combined, washed with 3 x 600 ml of water and distilled to dryness. Acetonitrile (300 ml) was added and the mixture was heated up to 75C. Water (300 ml) was added at >60 C, solution was allowed to cool to RT for precipitation and the mixture was stirred overnight at RT. Stirring was continued for additional 2 h at <10 C. The precipitate was filtered, washed with cold ACN: water and dried under vacuum to obtain 47 g of crude product. The title compound was recrystallized from EtOH with 75 % yield. -NMR (400 MHz, DMSO-

Electric Literature of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-(2-(Dimethoxyphosphoryl)acetyl)-1H-carbazole-1-carboxylic acid tert-butyl ester (0304-105) (375 mg, 1.0 mmol, 1.4 equiv),2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (300 mg, 0.73 mmol, 1.0 equiv) andCesium carbonate (900 mg, 2.8 mmol, 3.8 eq.)Added to 60 ml of isopropanol,The reaction was stirred at room temperature overnight, concentrated under reduced pressure, ethyl acetate and water were added,The layers were separated, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the product as a yellow solid 5-(3-(2-(1-triphenylmethyl-1H-imidazole-4-(phenyl)acryloyl)-1H-carbazole-1-carboxyl

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1-Trityl-4-imidazolyl)benzaldehyde, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17325-26-7, Product Details of 17325-26-7

EXAMPLE 1 12-{2-[4-chloro-3-(methyloxy)phenyl]-1 H-imidazol-4-yl}-N,N-dimethyl-1-[2-(m1 H-benzimidazole-5-carboxamidestep 1 s epstep 6Step 1. methyl 1 -({[2-(trimethylsilyl)ethyl]oxy}methyl)-1 /-/-imidazole-4-carboxylate: A mixture of methyl 1 H-imidazole-4-carboxylate (2.80 g, 22.20 mmol), {2-[(chloromethyl) oxy]ethyl}(trimethyl)silane (5.1 1 mL, 28.9 mmol) and potassium carbonate (7.67 g, 55.5 mmol) in DMF (20 mL) was heated at 80C for 24 hours. Reaction showed -1 :1 starting materiahdesired product by TLC. The reaction was cooled to room temperature, diluted with ethyl acetate and water, and layers were separated. Organics were washed with brine, concentrated and purified by Biotage (50 g silica column, 10-75% E/H, 20 min.; 75%, 10 min.). Clean fractions were combined, concentrated and dried to give the title compound as a light yellow oil (2.46 g, 45%). 1H NMR (400 MHz, DMSO-d6) delta 8.02 (d, J 1.26 Hz, 1 H), 7.92 (d, J = 1 .26 Hz, 1 H), 5.37 (s, 2H), 3.74 (s, 3H), 3.44 – 3.52 (m, 2H), 0.80 – 0.88 (m, 2H), -0.03 (s, 9H); MS (m/z) 257.0 (M+H)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Application of 4857-06-1, These common heterocyclic compound, 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a round bottom flask fitted with amagnetic stirrer, 2-chloro-1H-benzimidazole, 3, (0.50 g, 3.3 mmol) was dissolved in DMSO (3mL) and then NaH (60%; 0.19 g, 4.9 mmol) was added at 0 C and stirred for 1h. Next, benzylbromide (0.67 g, 3.9 mmol) was added to the suspension and the reaction was stirred at rt for 12h. Ice-cold water (15 mL) was added to the mixture and resulting precipitate was collected viafiltration. The filtrate was washed with water and dried under vacuum to give desired product, 4,as a white solid (0.75 g, 88%). LCMS: RT = 2.69 min., >98% 215 and 254 nm, m/z = 243.0 [M+ H]+. 1H NMR (499 MHz, CDCl3) delta 7.68 (d, J = 7.4 Hz, 1H), 7.35 – 7.24 (m, 5H), 7.16 (d, J =6.8 Hz, 2H), 5.38 (s, 2H). 13C NMR (126 MHz, CDCl3) delta 141.33, 134.83, 128.99, 128.22, 126.76,123.53, 123.05, 119.18, 109.98, 47.94.

Statistics shows that 2-Chloro-1H-benzo[d]imidazole is playing an increasingly important role. we look forward to future research findings about 4857-06-1.

Related Products of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (1.4 g, 3.37 mmol, 1.0 equiv),Compound (2-(3-Fluoro-4-nitrophenyl)-2-oxoethyl)phosphoric acid dimethyl ester (0702-102) (1.36 g, 4.38 mmol, 1.3 equivalents) andCesium carbonate (2.2 g, 6.74 mmol, 2.0 eq.)Mixed in isopropyl alcohol (30 ml),The reaction was stirred at room temperature overnight.After the reaction was completed, quenched with water and extracted with dichloromethane. The organic phase was dried over anhydrous sodium sulfate, concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol=100/1-50/ 1) Purification,The product (Z)-1-(3-fluoro-4-nitrophenyl)-3-(2-(1-trityl-1H-imidazol-4-yl)phenyl)prop-2-ene is obtained 1-ketone (1.8 g, yield: 92%).

The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.

16265-04-6, name is 2-Chloro-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 16265-04-6

4 g of 98% sulfuric acid, 2.04 g of 2-chloroimidazole ((? 02 mol) was added to the three-necked flask, and the mixture was stirred at room temperature (? 5h,And then heated to 45 ~ 55 C, slowly dropping from 1. 9g95% fuming nitric acid (0. 03mol) and 5g 20% fuming sulfuric acid composition of the mixed acid, after dropping, the temperature to 110 C reaction lh, the end After the reaction solution was poured into ice water, the pH was adjusted to 3 to 4 with aqueous ammonia, filtered and the cake was dried to give a white powdery solid 2-chloro-4-nitroimidazole, 56 mg, yield 87.3% HPLC purity 99. 4%, melting point 218. 6 ~ 219.5 C.

The synthetic route of 16265-04-6 has been constantly updated, and we look forward to future research findings.

Application of 144690-33-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 144690-33-5, name is Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 2; Potassium salt of 4-(l-hydroxy-l-methylethyl)-2-propyl-l-{4-[2-(tetrazol-5- yl)phenyl]phenyl}methylimidazole-5-carboxylic acid (4); Ethyl ester 3 (20 g) was dissolved in THF (80 ml) at 50 0C (60 minutes). After cooling to 25 0C, a 40% solution of KOH (10 ml) was added, and the mixture was stirred vigorously for 24 h. After adding ethyl acetate (10 ml), the solution cleared up (neutralization). After concentrating to ca. 40 ml in vacuo, the mixture was diluted with ethyl acetate (100 ml), and solid NaCl (20 g) was added. After separating the phases, the organic layer was filtered and concentrated to ca. 30 ml in vacuo. Methyl ethyl ketone (50 ml) was added to this solution, the mixture was concentrated to 30 ml in vacuo for the subsequent reaction.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate, other downstream synthetic routes, hurry up and to see.

Related Products of 312-73-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 312-73-2 name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2-(trifluoromethyl)-1H-benzo[d]imidazole (2 g, 10.7 mmol) in H2SO4 (55.2 g, 30 mL, 535 mmol) was added slowly hydrogen peroxide (35% solution, 10.4 g, 9.41 mL, 107 mmol) at 0-5 C. The reaction mixture was stirred at 120 C. for 3 h, cooled to RT, poured into water (80 mL) under ice bath cooling and extracted with diethyl ether (3*80 mL). The combined organic phase was dried over MgSO4, filtered and evaporated to give the product as colorless solid (1.98 g, 8.84 mmol, 82.2%) which was used without further purification for the next step. MS: M=225.4 (M+H)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(Trifluoromethyl)-1H-benzo[d]imidazole, and friends who are interested can also refer to it.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6775-40-2, name is 5-Phenyl-1H-imidazol-2-amine belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C9H9N3

General procedure: To a stirred solution ofaldehyde (1 mmol), amine (1 mmol), CCl3CN (2 mmol) in PEG-400 (5mL) at 0 oC, a solution of H2O2 (30%) (3mmol)was added drop wise. Then the reaction mixture was stirred at room temperature for 8-12 h. After completion ofthe reaction (monitored by TLC), the reaction mixture was poured into ice water (50 mL). The solid obtained wasfiltered, washed with water and crude product was purified by column chromatography (silica gel, 60-120 mesh)using hexane/ethylacetate (6:4) as eluent.

The synthetic route of 6775-40-2 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2963-77-1, name is 4-(1H-Benzo[d]imidazol-2-yl)aniline, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C13H11N3

General procedure: Using a typical scale of 1.0 mmol, 1 (1.0 mmol) was dissolved inanhydrous pyridine (2 mL) in a small round-bottomed flask and themixture was cooled to 40 C after which the acid chloride(2.0 mmol; purchased or prepared as above) in dry THF or DMF(2 mL) was added dropwise over 20 min with vigorous stirring.After 2-6 h the reaction mixturewaswarmed to room temperatureand the solvent reduced under pressure. Without using a work-upthe crude product was purified by column chromatography directlyusing MeOH/DCM mixtures (1:99 to 2:8).

According to the analysis of related databases, 2963-77-1, the application of this compound in the production field has become more and more popular.