Month: April 2021

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87233-54-3, name is 2-Chloro-1-(2-ethoxyethyl)-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C11H13ClN2O

Combine 2-chloro-1-(2-ethoxyethyl)-1H-benzimidazole (22.3 g, 99.4 mmol), 1-methyl[1,4]diazepane (19 mL, 152.8 mmol), and triethylamine (75 mL). Heat to 70 C. After 18 hours, add 1-methyl[1,4]diazepane (10 mL) and continue to heat at reflux. After 96 hours, cool to ambient temperature and partition the reaction mixture between water and ethyl acetate. Separate the layers and extract the organic layer with a saturated aqueous sodium bicarbonate solution and then brine. Dry the organic layer over MgSO4, filter, and evaporate in vacuo to give a residue. Chromatograph the residue on silica gel eluding sequentially with 50% ethyl acetate/hexane and then 10% methanol/dichloromethane to give 1-methyl-4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane: Rf =0.52 (silica gel, dichloromethane/methanol/concentrated aqueous ammonia, 90/10/0.1).

The synthetic route of 87233-54-3 has been constantly updated, and we look forward to future research findings.

Application of 872-49-1, The chemical industry reduces the impact on the environment during synthesis 872-49-1, name is 5-Chloro-1-methylimidazole, I believe this compound will play a more active role in future production and life.

Example 1 5-Chloro-1-methyl-4-imidazolesulfonic acid 33 g (0.28 mol) of 5-chloro-1-methylimidazole in 200 ml of fuming sulfuric acid are heated at 160-180 C. for 4 hours. After cooling, the reaction mixture is cautiously added to ice. The product crystallizes out from the cold aqueous solution (about 1.5 l). After recrystallizing twice from water, the title compound is obtained in the form of coarse yellowish crystals of melting point 309-310 C. Yield: 34 g (46.9% of theory).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-1-methylimidazole, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 614-97-1, name is 5-Methyl-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 5-Methyl-1H-benzo[d]imidazole

General procedure: Equivalent amount of the N-protected amino acid or dipeptide (1.45 mmol) (2a: 300 mg, 2b: 320 mg, 2c: 440 mg, 2d: 480 mg, 2e: 250 mg, 2f: 390 mg, 2g: 300 g, 2h: 440 mg, 2i: 250 mg, 2j: 390 mg, 2k: 300 mg, 2l: 320 mg, 2m: 440mg, 2n: 480 mg, 2o: 390 mg, 2p: 520 mg), benzimidazole (or its derivative) (1.45 mmol), (2a, 2b, 2c, 2d, 2e, 2f: 170mg, 2g, 2h, 2i, 2j: 190 mg, 2k, 2l, 2m, 2n, 2o: 240 mg, 2p:170 mg) and DCC (300 mg, 1.45 mmol) were reacted in dried THF (10 mL) under an atmosphere of argon for 3 h at room temperature and formed dicyclohexzylurea was filtered off. The volatiles were removed with reduced pressure. The residue was crystallized from ethanol/diethyl ether (1:2) (Fig. 1).

The synthetic route of 5-Methyl-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 33016-47-6, name is 1-Trityl-1H-imidazole-4-carbaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33016-47-6, Quality Control of 1-Trityl-1H-imidazole-4-carbaldehyde

Under argon atmosphere, 8.3 ML (4.43 mmol, 1.5 equivalent) of the solution of ethyl bromozincacetate in 2-methyltetrahydrofuran obtained in Example 67 was added dropwise to a solution of 1 g (2.96 mmol) of 1-trityl-1H-imidazol-4-carbaldehyde in 10 ML of THF at 5?8C. The mixture was stirred at 3?6C for 2 hours and 20 minutes.. The mixture was stirred at 20?25C for 1 hour and 15 minutes. 10 ML of 1N hydrochloric acid was added dropwise at 20C or lower, followed by dilution with 15 ML of ethyl acetate.. Then, the layers were separated.. The organic layer was washed successively with 5 ML (*2) of 1N hydrochloric acid, 5 ML of water, 5 ML (*2) of an aqueous saturated sodium bicarbonate solution, and 5 ML (*2) of an aqueous saturated sodium chloride solution.. After washing, the organic layer was dried with anhydrous magnesium sulfate.. After concentration under reduced pressure, recrystallization with 5 ML of IPE afforded 1.04 g of the desired product (yield 83%). 1H NMR was consistent with the compound obtained in Example 46.

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Reference of 4857-06-1,Some common heterocyclic compound, 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, molecular formula is C7H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of 1c (1.0 eq.) and POCl3 (10 eq.) was addeda few drops of conc. HCl. The reaction mixture was heated to 150 C and stirred for 3 h. After the reaction was completed, the reaction mixture was poured into ice water, neutralized with 1 N aq. NaOH and extracted with ethyl acetate. The organic layer was washed with water, dried over Na2SO4 and concentrated in vacuo to givecrude product 1d. Alternatively, to a stirred mixture of 2-chlorobenzimidazole (1.0 eq.) and R3CH2Br (1.0 eq.) in dimethylformamide was added N,N-diisopropylethylamine (1.5 eq.). The reaction mixture was heated to 110 C and stirred for 12 h. After the reaction was completed, the reaction mixture was cooled down to room temperature, diluted with ethyl acetate and washed with water. The organic layer was dried over anhydrous MgSO4 and concentrated in vacuo. The crude product was purified by flash column chromatography (ethyl acetate/hexane) to give desired product 1d.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-1H-benzo[d]imidazole, its application will become more common.

89830-98-8, name is 5-Cyclopropyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 89830-98-8

To a solution of 2-chloro-N-(2 ,4-d imethoxybenzyl)-5-n itrobenzenesulfonamide (700 mg,1.81 mmol) in acetonitrile (14 mL) were added 5-cyclopropyl-1H-imidazole (294 mg,2.71 mmol, CAS-RN 89830-98-8) and powdered potassium carbonate (750 mg,5.43 mmol) and the mixture was irradiated for lh at 12000 in the microwave. 4- Cyclopropyl-1H-imidazole (196 mg, 1.81 mmol) was added, and microwave irradiation was continued for 2h at 140°C. The reaction mixture was filtered and concentrated in vacuo, and the residue was extracted with dichloromethane and water. The aqueous phase was washed three times with dichloromethane. Then the combined organic phaseswere washed with brine and dried using a Whatman filter. Concentration under reduced pressure led to the title compound that was purified by flash chromatography (309 mg, 22percent yield, 60percent purity).LC-MS (Method A): Rt = 1.06 mm; MS (ESIpos): mlz = 459 [M+H]1HNMR (400MHz, DMSO-d6) oe [ppm]: 0.71 (m, 2H), 0.82 (m, 2H), 1.87 (m, 1H), 3.61 (s,3H), 3.68 (s, 3H), 4.01 (d, 2H), 6.33 (d, 1H), 6.36 (dd, 1H), 7.02 (d, 1H), 7.17 (s, 1H), 7.67 (d, 1H), 7.74 (s, 1H), 8.41 (dd, 1H), 8.43 (d, 1H), 8.49 (t, 1H).

The synthetic route of 89830-98-8 has been constantly updated, and we look forward to future research findings.

Reference of 4238-71-5, The chemical industry reduces the impact on the environment during synthesis 4238-71-5, name is 1-Benzyl-1H-imidazole, I believe this compound will play a more active role in future production and life.

1-Benzyl-2-iodo-imidazol (Compound 50, Scheme 19) was prepared by adding n-BuLi, (2.5 M in Hexane, 15.2 ml, 39 mmol) to a stirred solution of diisopropylamine (5.8 ml, 41.1 mmol) in THF (30 ml) at 0 C. After 30 minutes of stirring, the temperature was lowered to -78 C. and Compound 49 (1-benzyl-imidazol, 5 grams, 31.6 mmol) in THF (20 ml) was added thereto. The temperature was then increased to 0 C. and the reaction mixture was stirred at the same temperature for 30 minutes, then cooled down to -78 C. and finally iodine (8.8 grams, 34.8 mmol) in THF (20 ml) was added to the reaction mixture. The reaction mixture was stirred at room temperature for 2 hours and was quenched with aqueous NH4Cl, extracted with ethyl acetate, and the organic layer was washed with brine, dried over Na2SO4, and evaporated under reduced pressure to afford a crude product which was purified by column chromatography using silica gel and ethyl acetate:Hexane (1:1) as eluent to afford Compound 50 as yellow solid (6.5 grams, 72% yield).1H NMR (500 MHz, CDCl3)-delta: 7.36-7.29 (m, 3H), 7.14-7.11 (m, 3H), 7.00 (s, 1H), 5.09 (s, 2H);13C NMR (125 MHz, CDCl3)-delta: 135.5, 132.9, 128.9, 128.2, 127.2, 123.3, 90.6, 53;MS (ESI), m/z: 285 (MH+), 307 (MNa+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Benzyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference of 4856-97-7,Some common heterocyclic compound, 4856-97-7, name is (1H-Benzoimidazol-2-yl)methanol, molecular formula is C8H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE I STR28 A mixture of 2-Hydroxymethyl-benzimidazole (11.9 g) and MnO2 (59.5 g) in ethanol (250 mL) was vigorously stirred for 2 days. The reaction was concentrated in vacuo, hot dimethylformamide was added and the mixture was filtered through celite. After removal of the solvent in vacuo the tan solid was triturated with ethanol to afford 2-Benzimidazolecarboxaldehyde as a tan powder.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (1H-Benzoimidazol-2-yl)methanol, its application will become more common.

These common heterocyclic compound, 670-83-7, name is 2,5-Diphenyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C15H12N2

a. 1-Ethyl-2,4-diphenyl-1H-imidazole 50% aqueous KOH (40 mmol) and iodoethane (40 mmol) are added to a solution of 2,4-diphenyl-1H-imidazole (30 mmol) in DMF (50 mL), and the mixture is stirred at 40 C. under nitrogen for 16 hours. The reaction mixture is partitioned between water (300 mL) and ethyl acetate (200 mL). The organic layer is separated, washed with water (200 mL*2), dried over anhydrous magnesium sulfate, filtered and evaporated at reduced pressure. The residue is dissolved in xylenes (100 mL) and evaporated at reduced pressure. Chromatography on silica gel (chloroform) provides pure 1-ethyl-2,4-diphenyl-1H-imidazole. 13C NMR (400 MHz, CDCl3) delta=16.16, 41.43, 115.44, 124.57, 126.36, 128.26, 128.32, 128.54, 128.68, 130.55, 134.04, 140.87, 147.48.

The synthetic route of 2,5-Diphenyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Electric Literature of 1072-84-0,Some common heterocyclic compound, 1072-84-0, name is 1H-Imidazole-4-carboxylic acid, molecular formula is C4H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Will be 1.34g (12mmol)Imidazole-4-carboxylic acid is dissolved in 40 ml of anhydrous methanol.Add 3ml concentrated sulfuric acid, heat and reflux at 69.6 C for 12h.The reaction was completed until TLC was detected. The reaction solution was spun dry, and sodium hydrogencarbonate was added to adjust to weak acidity.It was diluted with 60 ml of ethyl acetate and the organic phase was washed with saturated sodium chloride (20 ml).Dry over anhydrous sodium sulfate, suction filtration, spin dry,Methyl imidazole-4-carboxylate (yellow brown solid)1.31g,The yield was 79.1%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole-4-carboxylic acid, its application will become more common.