Month: April 2021

Reference of 255064-08-5, These common heterocyclic compound, 255064-08-5, name is 6-Bromo-1H-benzo[d]imidazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 6-bromo-1H-benzo[d]imidazole-4-carboxylic acid(200 mg,0.84mmol) in THF(5 mL) and MeOH(1 mL) at 0 C was added trimethylsilyldiazomethane inEt20(2.0 M,0.63 mL,1.3 mmol). The reaction was stirred for 1 hat 0 C then warmed toRT.The reaction was quenched by addition of AcOH dropwise and concentrated in vacuo. Thecrude residue was diluted with DCM(20 mL) and washed with brine(10 mL). The organiclayer was dried over MgS04,filtered,and concentrated in vacuo. To a solution of the cruderesidue in DMF(2 mL) was added NaH(30 mg,1.25 mmol) at RT and stirred for 30 min.methyl iodide(120 mg,0.84 mmol) was added,and the reaction was stirred for 4 h at RT.The reaction mixture was cooled to-78 C and quenched with MeOH. The mixture wasdiluted into DCM/H20(20 mL,1:1),the organic layer separated and the aqueous layer wasextracted with DCM(2 x 5 mL). The combined organic extracts were dried over MgS04,filtered,and concentrated in vacuo. The crude residue was purified by reverse phasepreparative HPLC(Phenomenex Gemini C 18,H20/CH3CN gradient to 20-80 % MeCN 0.1%TFA) to aHord the title compound(83 mg,37%).

Statistics shows that 6-Bromo-1H-benzo[d]imidazole-4-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 255064-08-5.

Electric Literature of 17289-26-8, A common heterocyclic compound, 17289-26-8, name is 1-Methyl-1H-imidazole-4-carbaldehyde, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

14.1 Methyl (E) -3- (l-methyl-lH-imidazol-4-yl) acrylate1 ml (5.5 mmol) of methyl diethylphosphonoacetate are added to a suspension of 220 mg (5.5 mmol) of sodium hydride at 60% in 5 ml of tetrahydrofuran cooled to 00C. After stirring for 1 h, 500 mg (4.5 mmol) of 1- methyl-lH-imidazole-4-carbaldehyde are added and the mixture is stirred for 4 hours at ambient temperature and then hydrolysed with water and extracted with ethyl acetate. The organic phase is washed with a saturated aqueous solution of sodium hydrogen carbonate, dried over magnesium sulphate, filtered and evaporated. The product obtained is precipitated from heptane and filtered. 430 mg of methyl (E) -3- (1-methyl-lH-imidazol- 4-yl) acrylate are obtained in the form of a yellow powder with a yield of 57%.

The synthetic route of 17289-26-8 has been constantly updated, and we look forward to future research findings.

Electric Literature of 2849-93-6, A common heterocyclic compound, 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid, molecular formula is C8H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of tert-butyl-piperazine-1-carboxylate (1.75 g), benzimidazole-2-carboxylic acid (1.69 g), HOBt (1.52 g), WSC (1.75 g), and DMF (35 ml) was stirred at room temperature overnight. To the reaction liquid was added a saturated aqueous sodium hydrogen carbonate solution, followed by extraction with EtOAc. The organic layer was washed with saturated brine, then dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent; Hex_EtOAc=2:1 (V/V)) to obtain tert-butyl-4-(benzimidazol-2-ylcarbonyl)piperazine-1-carboxylate (2.4 g) as a white powder.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 952511-48-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 952511-48-7 as follows.

Example 46N4-(5-Cyclopropyl- 1 H-pyrazol-3-yl)-N2-methyl-N2-((4-methyl- 1 H-b enzo [d] imidazol-5- yl)methyl)pyrimidine-2,4-diamine (1-95)step 1 : To a solution of 5-bromo-4-methyl-lH-benzo[d]imidazole (1.0 g, 4.74 mmol, CASRN 952511-48- 7) and 3,4-dihydro-2H-pyran (2.0 g, 23.70 mmol) in THF (10 mL) was added / TsOH-H20 (90 mg, 0.47 mmol). The mixture was heated at 80 °C overnight, cooled and the solvent was removed in vacuo. The residue was diluted with DCM (100 mL) and water (50 mL). The organic layer was separated, dried (MgSO i), filtered and concentrated to dryness in vacuo. The crude product was purified by Si02 chromatography eluting with a petroleum ether/EtOAc gradient (10 to 50percent EtOAc) to afford 800 mg (57percent) of 5-bromo-4-methyl-l -(tetrahydro- 2H-pyran-2-yl)-lH-benzo[d]imidazole (254) as light yellow solid: MS (ESI) m/z = 295.1 [M+l]+.

According to the analysis of related databases, 952511-48-7, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde, A new synthetic method of this compound is introduced below., name: 1-Methyl-1H-imidazole-5-carbaldehyde

Example 3: : (2,4-Dichloro-3-(2-chlorophenyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)n-BuLi (2,5 M in hexanes, 0,52 mL, 1.3 mmol) was added dropwise to a solution ofn 6-bromo-2,4-dichloro-3-(2-chlorophenyl)quinoline (387.5 mg, 1 mmol, Intermediate 2: step c) in dry THF (10 mL) in a 500 mL three necked round bottomed flask at -78 C under N2. Stirring was continued for 30 minutes then a solution of 1-methyl-1H-imidazole-5-carbaldehyde (550 mg, 1 mmol) in dry THF (50 mL) was added at -78 C. The cooling bath was removed and the mixture was gradually warmed to room temperature and stirred for 2 hours. The mixture was quenched by adding H2O (10 mL) and then extracted with CH2Cl2 (2 x 50 mL). The combined organic phase was dried over Na2SO4, concentrated to dryness and purified by prep-TLC (developed by CH3OH/CH2Cl2 1:40) to afford the title compound as a white solid. MS (ESI): 418.1 [M+H]+. 1H NMR (300 MHz, CD3OD) delta ppm 8.47 (s, 1H), 8.06 (d, J = 8.6 Hz, 1H), 7.98-7.84 (m, 1H), 7.68- 7.34 (m, 5H), 6.57 (d, 3.3 Hz, 1H), 6.17 (s, 1H), 3.71 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 144690-33-5, name is Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C45H44N6O3

To a solution of the compound of Formula IV (5.0 g) in toluene (40 mL), dimethylacetamide (10 mL) is added, followed by addition of sodium hydroxide (1.2 g) and N,N-diisopropylamine (3.7 g) at 25-35C. The mixture is stirred at 40- 45C for 4 hours. 5-Methyl-2-oxo-(1 ,3-dioxolene-4-yl)methyl chloride (1.5 g) and tetrabutylammonium bromide (0.5 g) are added at 40-450C. The mixture is stirred at 60-70C for 8 hours. The mass is cooled to 25-35C, water (50 mL) is added, and the pH is adjusted to about 6-7 by adding 10% aqueous HCI. The layers are separated. The aqueous layer is extracted with toluene (25 mL). The organic layers are combined and washed with water (25 mL). The solvent is distilled under reduced pressure. Methanol (25 mL) is added to the residue. The mixture is cooled to 0-50C and stirred at that temperature for 45 minutes. The formed solid is filtered, washed with methanol (10 mL) and dried for 45 minutes under vacuum (yield 3.0 g).

The synthetic route of 144690-33-5 has been constantly updated, and we look forward to future research findings.

Application of 641571-13-3, The chemical industry reduces the impact on the environment during synthesis 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, I believe this compound will play a more active role in future production and life.

[00106] To a solution of 6-(3-Amino-phenylamino)-l ,3-dihydro-indol-2-one (36 mg, 0.15 mmol) and 3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-benzoic acid (53 mg, 0.195 mmol) in DMF (1.5 mL) is added N,N-diisopropylethylamine (78 muL, 0.45 mmol) followed by addition of HATU (63 mg, 0.165 mmol). The mixture is stirred at ambient temperature overnight. The mixture is diluted with EtOAc and washed with 10% Na2S2O3 aqueous solution and brine. The organic layer is separated, dried over MgSO4, EPO and concentrated. The crude product is used in the next step without further purification: LC-MS: 492.1 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 54624-57-6, name is 2-Bromobenzimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54624-57-6, name: 2-Bromobenzimidazole

To a stirred solution of Intermediate 13 (0.25 g, 0.92 mmol) in dry DMF (3 mL), TEA (0.5 mL, 3.71 mmol) and 2-bromo-1H-benzoimidazole (0.18 g, 0.92 mmol, Arbor chemicals) were added at rt and the reaction mixture was stirred at 100 °C overnight. It was cooled to rt and concentrated. This crude product was purified by flash column chromatography to afford the title compound (brown solid). 1H NMR (400 MHz, CDCl3): delta 7.33 (m, 2H), 7.07-7.06 (m, 2H), 6.86 (d, J=1.2 Hz, 1H), 6.76-6.74(m, 2H), 5.97-5.96 (m, 2H), 3.59-3.58 (m, 4H), 3.35-3.34 (m, 1H), 2.60-2.59 (m, 2H), 2.52-2.51 (m, 2H), 1.35 (d, J=8.0 Hz, 3H). LCMS: (Method A) 351.2 (M+H), Rt. 2.29min, 95.81 percent (Max). HPLC: (Method A) Rt. 2.19 min, 96.33percent (Max).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89830-98-8, name is 5-Cyclopropyl-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 5-Cyclopropyl-1H-imidazole

A solution of methyl 2,5- dioxo-2,3,4,5,7,8-hexahydro-[1,4]diazepino[7,1-a]isoquinoline-9-carboxylate (225 mg, 0.79 mmol) in DCE (20 mL) was treated with POCI3 (0.37 mL, 3.93 mmol) and the mixture was heated to 100 °C for 1 h. The mixture was then allowed to cool to RT, and then concentrated in vacuo, and dried azeotropically with toluene. The residue obtained was taken up in DCE (40 mL) and 4-cyclopropyl-1H-imidazole (261 mg, 2.41 mmol) were added. The mixture was heated to to 100 °C for 1h and then allowed to cool to RT, diluted with DCM and washed with a saturated aq, solution of NaHC03. The org. layer was dried over Na2S04, filtered and concentrated in vacuo. Purification by flash chromatography (Si02, AcOEt MeOH 100. to 90: 10) and crystallization in Et20/petroleum ether gave the title compound (116 mg). UPLC- MS: MS 377.2 (M+H+); UPLC rt 0.88 min. 1H NMR (600 MHz, DMSO-c/6): delta ppm 0.54-0.73 (m, 2H); 0.73-0.88 (m, 2H); 1.74-1.89 (m, 1 H); 3.25 (br s, 2H); 3.67-3.82 (m, 2H); 3.88 (s, 3H); 4.25 (br s, 2H); 7.13 (s, 1H); 7.44 (s, 1H); 7.48-7.57 (m, 1H); 7.96 (d, J=7.65 Hz, 1H); 8.09 (s, 1H); 8.19 (d, J=7.91 , 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 934-32-7, name is 1H-Benzo[d]imidazol-2-amine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 934-32-7, Recommanded Product: 934-32-7

General procedure: A mixture of aromaticaldehyde (1.0 mmol) and dimedone(1.0 mmol) with 2-aminobenzimidazole or 3-amino-1,2,4-triazole (1.0 mmol) was stirred in acetic acid (5 mL) at 60 Cfor the appropriate time (Tables 3, 4). The progress of thereaction was monitored by TLC. After completion of thereaction, a thick precipitate was obtained. The solid productwas filtered off and washed with acetic acid (3 × 2 mL) togive the pure products 4 and 6, and subsequently dried in air.The pure products were characterized by conventional spectroscopicmethods. Physical and spectral data for the compounds,4b, 4c, 4h, 4j, 6a, 6c, and 6h are represented below:

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Benzo[d]imidazol-2-amine, and friends who are interested can also refer to it.