Month: April 2021

Synthetic Route of 2849-93-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2849-93-6 name is 1H-Benzimidazole-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0401] To a 4 mL sample vial equipped with a magnetic stir bar was placed benzyl (7-amino-5-((2S,4S)-1-((R)-2-amino-3-cyclohexylpropanoyl)-4-(5-(2-hydroxypropan- 2-yl)-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxamido)-6,7-dioxoheptyl)carbamate (Intermediate L, 20 mg, 0.028 mmol, 1.0 equiv), 1H-benzo[d]imidazole-2-carboxylic acid (10 mg, 0.062 mmol, 2.2 equiv), HATU (12.7 mg, 0.033 mmol, 1.2 equiv) and DMF (400 muL). The solution was treated with EtN(iPr)2 (15 muL, 0.083 mmol, 3 equiv) and the mixture was stirred at room temperature for 18 h overnight. The reaction mixture was filtered through a 13 mm 0.45 muM PFTE syringe filter and the filtrate was collected. Purification of the filtrate by reverse-phase column chromatograph (Waters XSelect CSH Prep C18, 5 mum, 30 × 75 mm) using 60:40 to 35:65 H2O:MeCN + 0.1% HCO2H as a gradient over 10 minutes afforded the title compound. MS (ESI+) 826 (M+1) ^

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Benzimidazole-2-carboxylic acid, and friends who are interested can also refer to it.

Application of 1848-84-6, The chemical industry reduces the impact on the environment during synthesis 1848-84-6, name is 2-Ethyl-1H-benzo[d]imidazole, I believe this compound will play a more active role in future production and life.

General procedure: Sodium hydride (0.53 g, 6.6 mmol, 60percent oil dispresion) was added to the stirred solution of the corresponding azole (3.3 mmol) in anhydrous THF (2 mL) at room temperature. After 15 min, freshly prepared 2-(chloromethyl)-4,5-dihydro-1H-imidazole 2 (0.47 g, 4.0 mmol) was added and the reaction mixture was stirred at ambient temperature for 6 h. The N-alkylation products 3, 5, 7 and 8 were isolated upon quenching the reaction mixture with water (5 mL) followed by extraction with dichloromethane (3 .x. 5 mL). The combined organic layers were dried over anhydrous sodium sulfate and evaporated under reduced pressure. The oily residue thus obtained was purified on silica with use of chromatotron (Et3N/MeOH/AcOEt 1:5:100). All products were very polar with Rf values close to 0.05.The N-alkylation reaction of indazoles (1) provided the desired N1 substituted products (3) along with the N2 substituted side product. The latter compounds demonstrated considerably lower Rf than 3 and were not isolated in pure form. The alkylation reactions of benzotriazoles 6a and 6c allowed the isolation of N1 substituted products 7a-b (higher Rf) and N2 isomer 8b (lower Rf). However, in the case of 4-methyl-benzotriazole 6b only the N2 substituted isomer 8a was isolated as a pure product.The products 3, 5, 7 and 8 were then converted into water-soluble hydrochloride salts suitable for biological tests with use of methanolic hydrochloric acid solution or by passing gaseous hydrogen chloride through dichloromethane solution of the corresponding free base.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Ethyl-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Related Products of 934-22-5, These common heterocyclic compound, 934-22-5, name is 6-Aminobenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a vessel charged with N-(2-(1H-indol-3-yl)ethyl)-2-chloroquinazolin-4-amine (8a, 232 mg, 0.72 mmol)was added ethanol (5 mL), hydrochloric acid (10 mL), and 1Hindazol-5-amine (96 mg, 0.72 mmol). The vessel was sealed andstirred for 6 h at 120 C. The resulting mixture was dried underreduced pressure and subjected to silica gel column chromatographyusing dichloromethane/methanol (90:10) as the mobilephase to afford the desired compound 9a as a white solid (184 mg,0.87 mmol, 61% yield).

The synthetic route of 934-22-5 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of Methyl 1H-imidazole-5-carboxylate

(1) To a solution of methyl 4-imidazole carboxylate (a-1) (1.2 g, 9.5 mmol) and (4-fluorophenyl)methanol (h-1) (1.2 mL, 11 mmol) in THF (12 mL), PPh3 (3.0 g, 11 mmol) and DIAD (2.2 mL, 11 mmol) were added and the resulting mixture was stirred overnight at room temperature. The solvent was distilled off under reduced pressure and ethyl acetate and n-hexane were added; the resulting solids were recovered by filtration. The solvents in the filtrate were distilled off under reduced pressure and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=90:1050:50) to give methyl 1-(4-fluorobenzyl)-1H-imidazole-5-carboxylate (h-2) (amount, 1.6 g; yield, 73%).

The synthetic route of 17325-26-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 2302-25-2,Some common heterocyclic compound, 2302-25-2, name is 4-Bromo-1H-imidazole, molecular formula is C3H3BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 1-propanol (7.5 mL) and water (2.5 mL) was purged with nitrogen for 5 minutes. To the solution were added 4-bromo-1H-imidazole (146.97 mg, 1 mmol), 2-(hydroxyl-methyl)phenylboronic acid (190 mg, 1.25 mmol), Pd(OAc)2 (11.2 mg, 0.05 mmol), PPh3 (39.3 mg, 0.15 mmol) and potassium carbonate (276 mg, 2.0 mmol). After stirring at 85 C. for 16 h, the mixture was allowed to cool to room temperature and was partitioned between EtOAc (30 mL) and water (15 mL). The aqueous layer was extracted with EtOAc (2×20 mL) and the combined organic layers were washed with water, brine, and dried over sodium sulfate. The solvent was removed under reduced pressure and the crude product was purified by flash column chromatography on silica gel to afford the pure product (62 mg, 37% yield). 1H NMR: 4.48 (s, 2H), 6.25 (br s, 1H), 7.18-7.28 (m, 2H), 7.39-7.47 (m, 2H), 7.62 (d, 1H, J=7.0 Hz), 7.80 (d, 1H), 12.30 (br s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-1H-imidazole, its application will become more common.

Related Products of 5805-57-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5805-57-2 name is (1H-Benzo[d]imidazol-2-yl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a round bottom flask a mixture of (1H-benzo[d]imidazol-2-yl)methanamine (58; 720 mg, 3.8 mmol), 4,7-dichloroquinoline (1.07 g, 5.39 mmol) and phenol (2.33 g, 24.74 mmol) was heated for 3.5 h at 130 C, stirring under N2. After cooling, the mixture was dissolved in a solution of CH2Cl2/MeOH (95:5) and surplus of phenol was extracted with 2 N NaOH. The organic layers were washed with water, brine, dried over anhydrous Na2SO4 and evaporated to dryness. The crude solid was purified by CC on silica gel (CH2Cl2/MeOH; 93:7). The resulting product was rinsed with diethyl ether.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1H-Benzo[d]imidazol-2-yl)methanamine, and friends who are interested can also refer to it.

Related Products of 104-98-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 104-98-3, name is 3-(1H-Imidazol-4-yl)acrylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 1: Palladium on carbon (lO%, 150 g, 1.41 mol) was added to a solution of urocanic acid (1, 1.01 kg, 7.33 mol) in MeOH (5.50 L), water (5.50 L) and 35% HCI (752mL, 8.59 mol) and the resulting mixture was hydrogenated at normal pressure for 4 days. Conversion of the reaction was monitored by 1H NMR. The catalyst was filtered off after completion and the filtrate was evaporated to dryness. The residue was re-dissolved in MeOH (7.00 L) and 2.2 M solution of HCI in MeOH (500 mL) was added and stirred for 16 hours at 45 C. The solvents were removed by evaporation to dryness. MeOH (10.0 L)and HCI (47.0 g) in MeOH (1.00 L) were added and stirred overnight at 45 C. The mixture was evaporated to dryness to give pure 3-(1H-imidazol-4-yl)-propionic acid methyl ester hydrochloride (2) as off-white solid. Yield: 1.37 kg (98%). 1H NMR (300 MHz, MeOD-d4) o 7.40-7.28 (m, 10 H); 7.19-7.07 (m, 6 H); 6.55 (s, 1 H); 3.63 (s, 3 H); 2.94-2.83 (m, 2 H); 2.71-2.62 (m, 2 H).

The synthetic route of 3-(1H-Imidazol-4-yl)acrylic acid has been constantly updated, and we look forward to future research findings.

Application of 6478-73-5,Some common heterocyclic compound, 6478-73-5, name is 5,6-Dichloro-1H-benzo[d]imidazole, molecular formula is C7H4Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step B – Methyl 5-(5;6-dichbro-1Mbenzimidazoi-1-yf)-3-hydroxy-2~ thiophenecarboxyiateTo a solution of 5,6-dichloro-1 No.-benzimidazoIe (1.26 g, 8.72 mmoi) and methyl 2-ch.oro-3-oxo-2,3-dihydro-2-thiorhohe?ecarboxy.afe (1.49 g, 7.73 mmoi) in DCM (34 mL) was added NaHCO3 (1.70 g, 20.2 mmof) and M methylfmidazole (0.830 g, 10.1 mmo.) and heated at 400C overnight, The reaction mixture was cooled to it and DCM and wafer were added. The layers were separated and the aqueous layer was extracted with DCM. The combined organic layers were dried over Na2SO4 and filtered. S’lca was added to the filtrate and the volstiies were evaporated under reduced pressure and the residue was purified by flash column chromatography (0 to 100% EtOAc:hexane) to afford 1.5 g (65%) of the title compound. 1H NMR (300 MHz, DMSO-£/6) delta 10,88 (s, 1H), 8.76 (s; 1H), S.10 (s, 1H), 7.99 (S1 IH), 7.17 (s, 1H), 3.79 (S, 3H). MS (ESI): 343 {M+Hf.

The synthetic route of 6478-73-5 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-32-4, name is 1H-Imidazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1H-Imidazole

General procedure: A solution of imidazole 3 (30 mmol) in THF (60 mL) was treated with NaOH (25 mL, 40% aq) and the alkyl bromide (30 mmol), and the reaction was refluxed overnight. The solvent was evaporated and the crude reaction mixture was extracted with CH2Cl2 against water. The organic layer was washed with water, dried over MgSO4 and concentrated. The final product was distilled under vacuum (~5 mbar) to provide 4 as yellow oily liquid in 80-85% yield.

According to the analysis of related databases, 288-32-4, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 705-09-9, name is 2-(Difluoromethyl)-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2-(Difluoromethyl)-1H-benzo[d]imidazole

Nitrogen protection, 6 – chloro -8 – morpholine – [1, 3] two wicked [4, 5 – g] quinazoline (100 mg, 0 . 34mmol), 2 – (difluoromethyl) – 1H – benzo [d] imidazole ([reference literature preparation: J.Med.Chem. 2011, 54, 7105 – 7126] 113 mg, 0 . 68mmol), K2CO3(188 mg, 1 . 36mmol) mixed in the DMSO, heating to 130 C, stirring 4 hours. Cooling to room temperature, water quenching, extracted with ethyl acetate, dried, concentrated, the residue by silica gel column chromatography purification, shall 6 – (2 – (difluoromethyl) – 1H – benzo [d] imidazole -1 – yl) -8 – morpholine – [1, 3] two wicked [4, 5 – g] quinazoline (62 mg, 43%).

The synthetic route of 705-09-9 has been constantly updated, and we look forward to future research findings.