Synthetic Route of 705-09-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 705-09-9, name is 2-(Difluoromethyl)-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows.
Step 2: To a solution of Id (599mg, 3.57mmol) in DMF (20mL) was added NaH (143mg, 3.57mmol) with ice-bath. The resulting mixture was stirred for 15min. at 0-5 C and was added lc (1.43g, 3.57mmol). The reaction mixture was stirred at r.t. over night and evaporated to remove DMF. The residue was purified by column chromatography (PE:EA=1 :2) to give le (1.13g, 59.5% yield).
The chemical industry reduces the impact on the environment during synthesis 2-(Difluoromethyl)-1H-benzo[d]imidazole. I believe this compound will play a more active role in future production and life.