Reference of 68282-53-1, The chemical industry reduces the impact on the environment during synthesis 68282-53-1, name is 5-Methyl-1H-imidazole-4-carbaldehyde, I believe this compound will play a more active role in future production and life.
COMPOUND 14.1. 5: N*N-DIETHYL-4- {6-METHOXY-7-(4- METHOXYPHENOXY)-2-r (5-METHYL-lH-IMIDAZOL-4-YL) METHYL]-1 2, 3,4- TETRAHYDROISOQUINOLIN-1-YL} BENZAMIDE; To INTERMEDIATE 10.2. 3 (38 mg, 0.068 mmol) was added a solution of hydrogen chloride in 1, 4-dioxan (4M, 1 mL) at RT and the mixture was stirred for 1 hr. Solvent was removed by applying a stream of nitrogen and followed by under vacuum. The dried residue was re-dissolved in 1,2-dichloroethane (5 mL). To this solution were added 4-methyl-lH-imidazole-5-carboxaldehyde (9 mg, 0.0816 mmol, 1.2 eq) and sodium triacetoxyborohydride (43 mg, 0.2036 mmol, 3eq). The reaction mixture was stirred at room temperature for overnight and then quenched with saturated aqueous sodium bicarbonate (2 mL), extracted with ethyl acetate (2 x 10 mL). The combined extracts were washed with brine (2 x 5 mL), dried over MgSO4 and concentrated. Product was purified by flash chromatography to afford COMPOUND 14.1. 5 (11 mg, 0.020 mmol, 29%). 1HNMR (CDC13, 500 MHz): No. 1. 10 (br s, 3H), 1. 25 (br s, 3H), 2.11 (s, 3H), 2.58 (br m, 1H), 2.78 (br m, 1H), 2.96 (m, 1H), 3.07 (br m, 1H), 3.22 (br s, 2H), 3.36 (d, J 13 Hz, 1H), 3.54 (br s, 2H), 3.59 (d, J 13 Hz, 1H), 3.75 (s, 3H0, 3.82 (s, 3H), 4.50 (s, 1H), 6.27 (s, 1H), 6.58 (s, 1H), 6.73 (s, 3H), 7.22-7. 35 (m, 5H). 13C NMR (125 MHz, CDC13) : 8 10.94, 13.12, 14.44, 28.46, 39.67, 43.67, 46. 88, 49.13, 55.87, 56.24, 67.53, 112.49, 114.74, 118.26, 120.71, 126.52, 129.79, 130.79, 132. 91, 136.30, 144.17, 145.25, 149.95, 151.76, 155. 89, 171.52. (+) LRESIMS m/z 555 [M+H] +.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methyl-1H-imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.