Electric Literature of 641571-11-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 2- (4-ethoxy-6- ( (4-methoxybenzyl) oxy) pyridin-3-yl) -4-methylpyrimidine-5-carboxylic acid (0.2 g 0.506 mmol) in 1 4-dioxane (3 mL) stirred under N2at 20 was added Et3N (0.106 mL 0.759 mmol) and DPPA (0.167 g 0.607 mmol) in one charge. The reaction mixture was stirred at rt for 30 mins. To the mixture a solution of 3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline (0.122 g 0.506 mmol) in 1 mL of 1 4-dioxane was added. The reaction solution was heated to 100 with stirring for 3 hr. The solution was concentrated in vacuo and the residue was purified by preparative TLC (DCM/MeOH 101 Rf 0.5) to yield a off white solid of 1- (2- (4-ethoxy-6- ( (4-methoxybenzyl) oxy) pyridin-3-yl) -4-methylpyrimidin-5-yl) -3- (3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl) urea (60 mg 0.095 mmol 18.7yield) 1HNMR(400 MHz CD3OD) delta9.18 (s 1H) 9.15 (s 1H) 8.39 (s 1H) 8.25 (s 1H) 8.04 (s 1H) 7.81 (s 1H) 7.54 (s 1H) 7.25-7.23 (m 2H) 6.87-6.85 (m 2H) 6.48 (s 1H) 5.31 (s 2H) 4.13-4.10 (m 2H) 3.79 (s 3H) 2.82 (s 3H) 2.59 (s 3H) 1.40-1.36 (m 3H) ES-LCMS m/z 634.2 (M+H) .
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.