Synthetic Route of 39021-62-0,Some common heterocyclic compound, 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 54-(2-Chloro-11 -fhvdroxy-(3-methyl-3H-imidazol-4-yl)-methvn-dibenzofa,d1cvclohepten- 5-ylidene)-piperidine-1 -carboxylic acid tert-butyl ester 4-(11 -Bromo-2-chloro-dibenzo[a,d]cyclohepten-5-ylidene)-piperidine-1 – carboxylic acid tert-butyl ester (2.5 gm, 5.1 mmol) was dissolved in dry tetrahydrofuran. Cooled to -78 C under a nitrogen atmosphere. Driped in a solution of 2.5M nBuLi in hexanes (3.25 ml) and stir 15 minutes. Added a tetrahydrofuran solution of 3-Methyl-3H-imidazo.e-4-carbaldehyde (0.56 gm, 5.1 mmol) quickly and stirred at -78 C. Let warm up to room temperature slowly and stired 20 tirs. Added to brine and extracted with 3X 100 ml of ethylacetate. Combined the ethylacetate extracts, dried over magnesium sulfate, filtered and evaporateed to a solid. Chromatographed on silica gel using 3%-5% methanol/dichloromethane to obtain 1.09 gm of pure title product. ESI M+1= 519
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-5-carbaldehyde, its application will become more common.