Application of 60-56-0, A common heterocyclic compound, 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, molecular formula is C4H6N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A vial charged with 1 (0.25 g, 0.753 mmol), KF/Al2O3 (0.7 g) thiol (1.1 mmol), and 18-crown-6 (0.05 g, 0.225 mmol) in 5 mL of acetonitrile was heated for 20 h at 80 C. Then solvent was evaporated under reduced pressure and crude product was purified by flash chromatography on silica gel using the mixture petroleum ether – ethylacetate as eluent.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.