Application of 17325-26-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
1H-Imidazole-4-carboxylic acid methyl ester (1.8 g, 14 mmol, Aldrich) reacted with bromine (1.6 mL, 29.8 mmol, Adrich) in acetic acid (20 mL) was stirred at RT for 12 h. The reaction mixture was filtered from the yellow precipitate, and the filter cake was washed with DCM (2*20 mL). The cake was mixed with sat. aqueous solution of NaHCO3 (100 mL) and EtOAc (200 mL), and the mixture was stirred for 1 h at RT. The organic layer was separated and the aqueous phase was extracted with EtOAc (2*200 mL). The organic extracts were combined, dried over MgSO4 and filtered. The filtrate was concentrated and the residue was purified by preparative HPLC [gradient 10-85% MeCN (0.1% TFA)/H2O (0.1% TFA)] to give the title compound as light-yellow solid. MS (ESI, positive ion) m/z: 282, 284 (M+I).
The synthetic route of Methyl 1H-imidazole-5-carboxylate has been constantly updated, and we look forward to future research findings.