Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3034-38-6, name is 5-Nitro-1H-imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H3N3O2
A solution of LiOH.H2O (0.84 g, 20 mmol) in MeOH (10 mL) was added dropwise to a stirred mixture of 4-nitroimidazole (2.26 g, 20 mmol) and MeOH (20 mL) at rt. After stirring (30min) the clear dark orange solution was evaporated under reduced pressure to give a solid that was dried under high vacuum to give compound 12 (2.33 g, 98%) as an orange/brown solid. mp >300 C. 1H NMR (DMSOd6,250.1 MHz): d 7.34 (s, 1H, CH), 7.89 (s, 1H, CH). 13C NMR (62.9 MHz, DMSO-d6): d 127.4 (CH), 142.7 (CH),not observed (CNO2). MS (CI) m/z (%) 112 (M-, 100).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.