These common heterocyclic compound, 256518-97-5, name is 2-Chloro-5-iodo-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Chloro-5-iodo-1H-benzo[d]imidazole
2-Chloro-6-iodo-1H-benzimidazole (2.34 g, 8.4 mmol), isopropylboronic acid (0.81 g, 9.2 mmol), tetrakistriphenylphosphine palladium (0.09 g, 0.08 mmol) were added to the reaction vessel. Potassium carbonate (3.48g,25.2 mmol), 60 mL of toluene, 20 mL of ethanol and 20 mL of distilled water were stirred at 120 C for 3 h. After the completion of the reaction, the reaction was quenched with distilled water, ethyl acetate was evaporated, and the organic layer was dried (MgSO4).(1.18g, 72%).
The synthetic route of 2-Chloro-5-iodo-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.