Synthetic Route of 60713-78-2, A common heterocyclic compound, 60713-78-2, name is 5-Chloro-6-nitro-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C7H4ClN3O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 5-chloro-6-nitro-1 ,3- dihydro-benzoimidazol-2-one (5.63 g, 26.35 mmol) was added phosphorus oxychloride (35 ml_) and the reaction mixture was heated to 85 0C for 36 h. The reaction mixture was concentrated and the residue triturated with cold saturated aqueous sodium bicarbonate (to pH 8, 0.8 L). The resulting precipitate was collected and dried to yield the titled compound (5.43 g, 89% yield). MS (ESI/CI): mass calcd. for C7H3CI2N3O2, 231.0; m/z found, 232.0 [M+H]+. Step C: 2,6-Dichloro-1 -(2-methoxy-ethoxymethyl)-5-nitro-1 /-/-benzoimidazole.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2009/134750; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem