Adding a certain compound to certain chemical reactions, such as: 57667-50-2, name is 1-Propyl-1H-benzo[d]imidazol-2-amine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 57667-50-2, name: 1-Propyl-1H-benzo[d]imidazol-2-amine
General procedure: 6.1.2. Method BTo a solution of 1-(un)substituted-2-aminobenzimidazole (0.01 mol) in dry acetonitrile (50 ml) was added anhydrous potassium carbonate (2.7 g, 0.02 mol) and tetrabutyl ammonium bromide (TBAB) (0.9 g, 0.003 mol) and 0.02 mol of the halogen organic reagent was dropped by cooling. The mixture was stirred for 2-5 h vigorously at 25 C and monitored by TLC over the reaction period. After completion of the reaction, the mixture was filtered to separate the solid K2CO3, and the organic solvent was evaporated. The residue was then crystallized from appropriate solvent to give products 4-8.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Article; Mavrova, Anelia Ts.; Wesselinova, Diana; Vassilev, Nikolay; Tsenov, Jordan A.; European Journal of Medicinal Chemistry; vol. 46; 8; (2011); p. 3362 – 3367;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem