Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 934-22-5, name is 6-Aminobenzimidazole, A new synthetic method of this compound is introduced below., COA of Formula: C7H7N3
Compound 467: 1 -(1 H-benzo[d]imidazol-6-yl)-5-(2,3-difluorophenyl)-3-hydroxy-4- methyl-1 H-pyrrol-2(5H)-one; 1 H-Benzoimidazol-5-ylamine (1 mmol) was dissolved in 5ml_ of dry EtOH and 2,3- difluorobenzaldehyd (1 mmol) were added. The solution was stirred overnight and after that 2- oxal-propionsaure diethylester (1 mmol) was added and the solution was stirred for 2Oh at 500C. After that the solvent was evaporated and remaining oil was subjected to a flash chromatography device and purified by means of a CHC^/MeOH gradient. The purified carboxylic acid ethyl ester derivative was suspended in 1OmL of a 10% aqueous solution of HCI and kept for 3h at reflux. The resulting precipitate was filtered off and dried. Yield: 0.15Og (46 %);1H-NMR (400 MHz, CD3OD), 1.78 (s, 3H, CH3), 6.06 (s, 1 H, CH-N), 6.94 – 7.17 (m, 3H, aro), 7.74 (s, 2H, benzimid), 8.08 (s, 1 H, benzimid), 9.27 (s, 1 H, benzimid), MS m/z 342.1 (M+H)+, HPLC (254 nm): purity 100 %molecular weight (g/mol): 341.3 Ki hQC (nM): 1 1.6
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PROBIODRUG AG; WO2008/55945; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem