Reference of 35203-44-2,Some common heterocyclic compound, 35203-44-2, name is 1-Propyl-1H-imidazole, molecular formula is C6H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of 4-(bromomethyl)-6-methyl-coumarin (0.506 g, 2 mmol) in 30 mL of anhydrous dioxane, N-methylimidazole (0.164 g, 2 mmol) was added drop wise. The mixture was stirred for 48 h at 85 °C, after which a white solid obtained was filtered, washed with fresh anhydrous dioxane and dried. Then, to a methanolic solution (10 mL) of obtained bromide salt 1 (1 g, 2.5 mmol), 1-ethyl-3-((6-methyl-2-oxo-2H-chromen-4-yl)methyl)-3-propyl-1H-imidazolium bromide, KPF6 (0.691 g, 3.75 mmol) in 10 mL of water methanol (1:9 v/v) mixture is added drop wise under continuous stirring, white solid separates out. The reaction is allowed to stir for another 2 h after which excess water is added to the reaction mixture and filtered. This off-white solid was recrystallized by repeated precipitation using acetonitrile and diethyl ethyl ether mixture to afford pure imidazolium hexafluorophosphate salt 8.
The synthetic route of 35203-44-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Achar, Gautam; Shahini; Patil, Siddappa A.; Budagumpi, Srinivasa; Journal of Organometallic Chemistry; vol. 833; (2017); p. 28 – 42;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem