Reference of 641571-11-1, A common heterocyclic compound, 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is C11H10F3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
0 ~ 5 ,A solution of 3- (4-methyl-1H-1-imidazolyl) -5-trifluoromethylaniline (24.1 g, 0.1 mol)Acetyl chloride (11.7 g, 0.15 mol) and dichloromethane (150 mL) were added to a three-necked reaction flask,Triethylamine (15.0 g, 0.15 mol) was added dropwise with stirring,After that,Heating up to 25 ~ 35 ,Reaction for 2 hours,TLC detection, to the raw material reaction completely.The reaction solution was poured into ice water, and the layers were allowed to stand. The aqueous phase was extracted with methylene chloride, the organic phase was combined, washed with 10% sodium hydrogencarbonate solution, dried, the solvent was removed under reduced pressure,Get like white solidN- [3- (4-methyl-1H-1-imidazolyl) -5-trifluoromethylbenzene] acetamide (III)(Acetyl-protected compound of formula II)
The synthetic route of 641571-11-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Suzhou Lixin Pharmaceutical Co., Ltd.; Xu Xuenong; Bao Zhijian; Su Jian; Xue Jia; Gu Xinyu; Huang Dongliang; Chen Wei; Wang Zhe; (6 pag.)CN107188887; (2017); A;,
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