Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Chloro-1H-benzo[d]imidazole
Step 3: Under the protection of nitrogen, 2-chlorobenzimidazole (1.41 g, 9.2 mmol) and phenylboronic acid were added to the reaction vessel. (1.02 g, 8.4 mmol), tetrakistriphenylphosphine palladium (0.09 g, 0.08 mmol), potassium carbonate (3.48 g, 25.2 mmol), toluene 60 mL, ethanol 20 mL, and distilled water 20 mL, and stirred at 120 C for 3 h. After the end of the reaction, the reaction was quenched with distilled water, extracted with ethyl acetate, and the organic layer was dried over MgSO 4 After purification by silica gel column chromatography, Intermediate 73-3 (1.22 g, 75%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Dong Xiuqin; Cai Hui; (34 pag.)CN108409668; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem