Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 17325-26-7
1H-Imidazole-4-carboxlic acid methyl ester (293.8mg, 2.33mmol), 4-bromo-6- cyclohexyl-pyrane-2-one (300mg, 1. 17mmol) and potassium carbonate (483. 8mg, 3. 50MMOL) were introduced into a 50ML flask, and the flask was then filled with nitrogen gas. After acetonitrile (LOML) was added thereto, the reaction solution was refluxed for 2 hours and then cooled down to room temperature. The precipitate was filtered off, and the filtrate was distilled under reduced pressure. The residue was purified by column chromatography on silica gel using MC: MEOH (20: 1) as eluent. The fractions containing the product were combined and evaporated to give a white solid (290mg, 82.2%). ‘H-NMR (CDCI3) ; 8 =7.99 (2H, m), 6.19 (2H, m), 3.98 (3H, s), 2.52 (1H, m), 1.99 (5H, M), 1.40 (5H, m).
The synthetic route of 17325-26-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; C & C RESEARCH LABORATORIES; WO2004/50624; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem