Electric Literature of 288-32-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-32-4, name is 1H-Imidazole, This compound has unique chemical properties. The synthetic route is as follows.
Under ice-cooling, sodium hydride (60%, 1.40 g, 35 mmol) was added in one portion to dry tetrahydrofuran (25 mL), and the resulting reaction solution was warmed to room temperature and stirred for 30 minutes.Under ice-cooling, 1H-imidazole (2.00 g, 30 mmol, 6 mL of dry THF solution) was added dropwise, and the resulting reaction solution was warmed to room temperature and stirred for 1.5 h.1-Bromo-3-chloropropane (4.60 g, 30 mmol) was added dropwise and the reaction was allowed to react at room temperature overnight.Methanol (5 mL) was added to the reaction system in one portion, filtered, the solvent was distilled off under reduced pressure, and the crude product was purified by column chromatography (dichloromethane/methanol (V/V) = 30/1).A pale yellow oil (3.10 g, 73%) was obtained.
The chemical industry reduces the impact on the environment during synthesis 1H-Imidazole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, YINGJUN; ZHANG, JIANCUN; WANG, XIAOJUN; LIN, RUNFENG; CAO, SHENGTIAN; WANG, ZHAOHE; LI, JING; (226 pag.)TWI607995; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem