Month: May 2021

Reference of 26530-93-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26530-93-8, name is 1-Methyl-1H-benzo[d]imidazol-6-amine, This compound has unique chemical properties. The synthetic route is as follows.

3.2 3-{(Z)-1-[(1-methyl-benzimidazol-6-yl)amino]-1-phenylmethylidene}-2-indolinone Prepared from 1-acetyl-3-{1-ethoxy-1-phenylmethylidene}-2-indolinone and 2 equivalents of 6-amino-1-methyl-benzimidazole, melting point 163-165° C., in DMF followed by treatment with 1N sodium hydroxide solution in MeOH. Yield: 54percent of theory; Melting point: 298-300° C.; C23 H18 N4 O; Calc.: C, 75.39; H, 4.95; N, 15.29; Found: 75.16; 5.00; 15.18; Calc.: molar peak M+ =366; Found: molar peak M+ =366.

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-benzo[d]imidazol-6-amine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Boehringer Ingelheim Pharma KG; US6043254; (2000); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24134-65-4, name is 1,3-Dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-sulfonyl chloride, A new synthetic method of this compound is introduced below., Application In Synthesis of 1,3-Dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-sulfonyl chloride

Take 1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo [d] imidazole-5-sulfonyl chloride (0.5 g, 1.9 mmol),(1-benzylpiperidin-4-yl) methylamine (0.4 g, 1.9 mmol),Triethylamine (0.4g, 3.8mmol) was added to the eggplant-shaped bottle, and then dichloromethane was added, and the reaction was performed at room temperature for 6 hours;After the reaction, add water, wash with brine 3 times, spin dry, and pass through the column.A white solid was obtained with a yield of 76%.TLC detected one point, there was fluorescence at 254nm and no fluorescence at 365nm.

The synthetic route of 24134-65-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; China Pharmaceutical University; Sun Haopeng; Mo Jun; Li Qihang; Yang Hongyu; Chen Yao; Chen Tingkai; Li Qi; Guo Yan; Liu Zongliang; Feng Feng; Liu Wenyuan; (19 pag.)CN110776494; (2020); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1008360-84-6, name is 5-Bromo-6-fluoro-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C7H4BrFN2

To a solution of 5-bromo-6-fluoro-1-(triphenylmethyl)-1H-benzimidazole and 6-bromo-5-fluoro-1-(triphenylmethyl)-1H-benzimidazole (2.0 g, 4.4 mmol) in toluene (10 mL) under nitrogen atmosphere was added tetrakis(triphenylphosphine) palladium(0) (0.25 g, 0.2 mmol) followed by a solution of sodium bicarbonate (0.92 g, 11.0 mmol) in water (5 mL). A solution of 4-formylphenylboronic acid (0.72 g, 4.8 mmol) in ethanol (3 mL) was then added and the reaction was heated at reflux overnight. After removal of the solvent in vacuo, the residue was partitioned between ethyl acetate and water. The combined organics were dried over sodium sulfate, concentrated in vacuo, and purified via chromatography (20 to 50% ethyl acetate/hexanes) to provide the product as a mixture of trityl regioisomers, 4-[5-fluoro-1-(triphenylmethyl)-1H-benzimidazol-6-yl]benzaldehyde and 4-[6-fluoro-1-(triphenylmethyl)-1H-benzimidazol-5-yl]benzaldehyde.Isomer a: 1H NMR (400 MHz, CDCl3) delta 6.45-6.48 (m, 1H), 7.16-7.26 (m, 8H), 7.35-7.39 (m, 9H), 7.65-7.72 (m, 1H), 7.81 (d, J=7.4 Hz, 1H), 8.12-8.22 (m, 1H), 9.99 (s, 1H).Isomer b: 1H NMR (400 MHz, CDCl3) delta 6.27 (d, J=11.2 Hz, 1H), 7.17-7.21 (m, 6H), 7.34-7.37 (m, 9H), 7.70 (d, J=6.6 Hz, 2H), 7.85 (d, J=7.1 Hz, 1H), 7.92-7.96 (m, 3H), 10.04 (s, 1H).

The synthetic route of 1008360-84-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Diaz, Caroline Jean; Haffner, Curt Dale; Speake, Jason Daniel; Zhang, Cunyu; Mills, Wendy Yoon; Spearing, Paul Kenneth; Cowan, David John; Green, Gary Martin; US2010/222345; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 65039-05-6, name is 1-Butyl-3-methylimidazolium iodide, A new synthetic method of this compound is introduced below., Safety of 1-Butyl-3-methylimidazolium iodide

(1) Take 10g of 98% purity by mass of 3-methyl-1-butyl iodide was added 25mL imidazole dissolved in distilled water, was added 50mL of 45% concentration of hydrofluoric acid, sealed and heated to 60oC with stirring;(2) reaction of starting material at least sufficient 3h, then heated to 100oC, excess hydrogen fluoride was evaporated and the product gas of hydrogen chloride gas, tail gas absorption using calcium oxide, not dehydrated to give 1-butyl-3-methylimidazolium ionic liquids fluoride ;(3) not dehydrated to 1-butyl-3-methyl-fluorinated ionic liquid was diluted with distilled water is added, not dehydrated butyl-3-methyl-fluorinated ionic liquid volume of distilled water is less than 1:50, dilution was added to the AgNO3 solution, if precipitation production, continue to add 20mL hydrofluoric acid, repeating (1) and (2) step until no precipitate was produced, purified non-dehydrated 1- butyl-3 – methyl fluoride ionic liquid;(4) The dehydrated purified non-3-methyl-1-butyl fluoride at 120oC ionic liquid was dried under high vacuum at least 48h, in addition to the depth of water, in addition to hydrogen fluoride, to give a viscous liquid, of a viscous liquid testing, viscous liquid was added to distilled water, distilled water and the volume of viscous liquid is less than 50, sealed and heated to 50oC, with hydrogen detector dilution residual amount of hydrogen fluoride, if the reading is greater than> 0.1ppm, continue at 120oC under high vacuum drying in addition to hydrogen fluoride untilInspection hydrogen fluoride concentration <0.1ppm; if detected hydrogen fluoride concentration <0.1ppm, the resulting liquid is 1-butyl-3-methyl fluoride ionic liquid, weighing 5.69g. The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future. Reference:
Patent; Beijing University; Li, Zhongning; Zhong, Xiongwei; Xiong, Ting; Hu, Xianwei; Xu, Junli; Wang, Zhaowen; Gao, Bingliang; Yu, Jiangyu; (27 pag.)CN103992275; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 1008360-84-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1008360-84-6, name is 5-Bromo-6-fluoro-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

step 4: A mixture of 100 (550 mg, 2.57 mmol), TsOH-H20 (50 mg, 0.26 mmol), and 3,4-dihydro-2H- pyran (1.08 g, 12.85 mmol) in THF (10 mL) was heated at reflux overnight. After the solvent was removed in vacuo, the residue was partitioned between DCM (300 mL) and water (100 mL). The organic layer was separated, dried (MgSO i), filtered and concentrated in vacuo. The residue was purified by S1O2 chromatography eluting with a MeOH/DCM gradient (0.5 to 1% MeOH) to afford 817 mg (100%) of 5- bromo-6-fluoro-l -(tetrahydro-2H-pyran-2-yl)-lH-benzo[d]imidazole (102) as yellow oil: MS (ESI) m/z = 299 [M+l] +.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-6-fluoro-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim; WO2013/26914; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 14003-66-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14003-66-8, name is 4-Methyl-5-nitro-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Synthesis 90 (E)-4-(2-(5-Nitro-1 H-imidazol-4-yl)vinyl)benzonitrile4-Cyanobenzaldehyde (75 g, 0.57 mol) was heated to 1100C. Once melted, 4-methyl-5- nitroimidazole (15 g, 0.12 mol) and piperidine (5 g, 0.06 mol) were added and heating continued for a further 24 hours. DMF (15 ml.) and IPA (150 mL) were then added and the precipitate filtered from solution and washed with IPA (50 mL) to leave the product as a yellow solid (13.8 g, 49%). mp > 30O0C. deltaH (DMSO-cfe) 7.95 (1H1 s), 7.88 (2H, d, J = 6.8), 7.78 (2H, d, J = 6.8), 7.78 (1H, d, J = 16.8), 7.50 (1 H, d, J = 16.8); IR (cm 1) 2239 (C?N), 1502, 1348 (NO2); MS (m/z) 241.1 (Ci2H9N4O2 (M+1)).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methyl-5-nitro-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PHARMINOX LIMITED; HUMMERSONE, Marc, Geoffery; STEVENS, Malcolm, Francis, Graham; COUSIN, David; WO2010/149968; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 154094-97-0, name is 2-(1H-Imidazol-1-yl)ethanamine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., Formula: C5H10ClN3

Example 1 : Synthesis of 2-Cyclopentyl-2-hydroxy-lambda/-[2-(lH-imidazol-l-yl)ethyll-2- phenylacetamide (Compound No. 1) To a solution of the hydrochloride salt of 2-(lH-imidazol-l-yl)ethanamine (0.5 g, 4.50 mmol) in chloroform (10 ml) was added N-methyl morpholine (2.96 ml, 27.02 mmol) and stirred the mixture for 5 to 10 minutes at the room temperature followed by the addition of 2- cyclopentyl-2-hydroxy-2-phenyl acetic acid (0.99 g, 4.5 mmol) and hydroxy benzotriazole (0.60 g, 4.5 mmol) at room temperature. The resulting reaction mixture was stirred for 30-45 minutes followed by the addition of l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and again stirred for over night. The mixture was diluted with water and stirred for 10-15 minutes followed by the addition of dichloromethane. The mixture was stirred for 15-20 minutes. The organic layer was separated, washed with water and brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure. The residue thus obtained was purified by preparative column chromatography using 10 % methanol in dichloromethane as eluent to furnish the title compound. Yield: 70 mg.1H NMR (CDCl3)delta: 7.60-7.31 (5H, m), 6.99 (IH, s), 6.99 (IH, s), 6.65 (IH, s), 4.01-4.00 (2H, m), 3.99-3.49 (2H, m), 3.11-3.07 (IH, m), 1.64-1.42 (8H, m).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 154094-97-0.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; WO2007/77510; (2007); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 139481-69-9, A common heterocyclic compound, 139481-69-9, name is Methyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate, molecular formula is C25H22N6O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

50 grams of methyl 2-ethoxy-1-[[2′- (1 H-tetrazol-5-yl) biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate, 100 ml of N, N-dimethylformamide, 22.6 grams ofbenzylbromide and 45.7 grams of potassium carbonate were charged in a roundbottom flask. The reaction mass was heated to about 60-65C and stirred forabout 1-3 hours followed by cooling to about 25-30C. Reaction mass wasquenched with a mixture of sodium chloride (100 grams) and water (1 litre) understirring. Reaction mass was extracted with 2×250 ml and was washed with 2x250ml water. Organic and aqueous layers were separated and evaporated the solventcompletely by distillation at about 35-40C

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; WO2006/15134; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 93668-43-0,Some common heterocyclic compound, 93668-43-0, name is 2-(1H-Imidazol-1-yl)ethanamine dihydrochloride, molecular formula is C5H11Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 1.47 g. portion of 1H-imidazole-1-ethanamine dihydrochloride was reacted with 3-chloro-benzo[b]thiophene-2-carbonyl chloride as described in Example 1, giving 0.75 g. of the desired product, m.p. 132-134 C.

The synthetic route of 93668-43-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; American Cyanamid Company; US4489089; (1984); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 20271-20-9,Some common heterocyclic compound, 20271-20-9, name is Methyl 5-nitro-1H-imidazole-4-carboxylate, molecular formula is C5H5N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of Description 17 (1.24g, 7. 25 mmol) in1 : 1 ethanol : methanol (60 ml) was hydrogenated using 10 % palladium on carbon catalyst under a balloon of hydrogen. After 4 h the reaction mixture was filtered, the filtrate condensed and azeotroped with ethanol. The product was triturated with ethyl acetate and dried to give the title compound as a white solid (0.98 g, 96%).’H NMR (400 MHz, DMSO)8 12.0(1H, brs), 7.32(1H, s), 5.56 (2H, s), 3.70 (3H, s). Mlz (ES+) 142 (M+H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 5-nitro-1H-imidazole-4-carboxylate, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; HOLLINGWORTH, Gregory, John; JONES, A., Brian; SPAREY, Timothy, Jason; WO2005/49613; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem