Month: May 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89088-69-7, name is 1-Methyl-1H-imidazol-4-amine hydrochloride, A new synthetic method of this compound is introduced below., SDS of cas: 89088-69-7

Intermediate 19; 1 -Ethyl-iV-d -methyl- lH-imidazol-4-yl)-6-(methylsulfonyl)- lH-pyrazolo[3 ,4-

Synthetic Route of 3718-04-5, These common heterocyclic compound, 3718-04-5, name is 5-Vinyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of Intermediates C Intermediate CI (iT)-2-(4-fluorophenyl)-6-methoxy-l-methyl-l-(4-(2-(l-((2-(trimethylsilyl)ethoxy)methyl)-lH- imidazol-4-yl)vinyl)phenyl)-1.2.3.4-tetrahydroisoquinoline To a 30 mL screw cap vial, 4-vinyl-lH- imidazole (260 mg, 2.76 mmol) was dissolved in dimethylformamide (4 mL) and charged with sodium hydride (60% dispersion in mineral oil, 331 mg, 8.29 mmol). The reaction mixture was stirred at room temperature for 15 min at which time. 2-(Trimethylsilyl)ethoxymethyl chloride (490 muL, 2.76 mmol) was added and the reaction mixture was left to stand for 90 min. The reaction mixture was cooled to 0 C and quenched saturated ammonium chloride. The crude mixture was diluted with dichloromethane, the layers were separated, the organic layer was washed with water and brine. The organic layer was passed through phase separator and concentrated. The crude product was purified by silica gel chromatography (0%-100% ethyl acetate/heptanes) to afford a regioisomeric mixture of l-((2- (trimethylsilyl)ethoxy)methyl)-4-vinyl-lH-imidazole as a white solid (540 mg, 87%). LC MS (m/z, MH+): 225.4.

Statistics shows that 5-Vinyl-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 3718-04-5.

Electric Literature of 255064-10-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 255064-10-9 name is 6-Bromo-4-methyl-1H-benzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(Bromomethyl) cyclopropane (3.75 mmol, 0.36 mL) was added drop-wise to mixture of 6-bromo-4-methyl-lH- benzo [d] imidazole (2.5 mmol) and potassium carbonate (3.75 mmol, 0.52 g, ) in DMF (8 mL). The mixture was stirred at room temperature for 48 hours and 60°C for 3 h. The mixture was diluted with ethyl acetate and water and the organic extract was washed with brine, dried (MgS04) and concentrated under reduced pressure. Purification of the crude product by column chromatography (silica gel, gradient of 30-100percent ethyl acetate in isohexane) gave the title compound (containing ~25percent of the isomeric 5-bromo- 1- (cyclopropylmethyl) -7-methyl-lH-benzo [d] imidazole) as an off-white solid (0.29 g, 44percent).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Bromo-4-methyl-1H-benzo[d]imidazole, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 5098-11-3, name is 5-Amino-1H-imidazole-4-carbonitrile, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5098-11-3, Quality Control of 5-Amino-1H-imidazole-4-carbonitrile

General procedure: Na3PSO3·xH2O (?90% purity, 0.320 mmol, 64 mg) was dissolvedin degassed 10% D2O in H2O (0.5 mL) in an Eppendorf tube andthe pH was lowered to 6.5 (5.0 in the case of 26) using degassedHCl. The nitrile was added (0.080 mmol), and the volume madeup to 1 mL with degassed 10% D2O. The reaction was sealed andheated at 50 C for 24 h taking time points at 8 and 24 h.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

6232-92-4, name is 6-Nitro-1H-benzo[d]imidazol-2-amine, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H6N4O2

A mixture of 4-bromo-1H-imidazole (1.0 g, 6.80 mmol) in dimethylformamide (5 mL) was stirred at 0C, to which was added sodium hydride, 60% suspension in oil, (326 mg, 8.20 mmol). The reaction mixture was warmed to room temperature and stirred for 30 minutes, followed by dropwise addition of 2-bromopropane (0.70 mL, 7.48 mmol). The reaction mixture was stirred at room temperature for 15 hours under nitrogen, then quenched with water (10 mL) and extracted with ethyl acetate (3 x 15 mL). The combined organic extracts were washed with water (20 mL) and extracted with 1M hydrochloric acid (3 x 20 mL). The combined acidic extracts were washed with ethyl acetate (20 mL), then basified with ammonium hydroxide (pH 12), and extracted with ethyl acetate (3 x 20 mL). The combined organic extracts were dried (Na2SO4), filtered and concentrated. Preparative HPLC, eluting with an ethyl acetate- isohexane gradient, gave the product as a pale brown oil (380 mg, 30%) 8 (1H, 400MHz, CDCl3) 1.47 (6H, d, J = 6.8Hz), 4.28-4. 32 (1H, m), 6.92 (1H, d, J = 1.5 Hz), 7.40 (1H, d, J = 1.5 Hz). MS (ES+) 189,191 ([MH]+).

The synthetic route of 6232-92-4 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 38585-62-5, name is (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride

EXAMPLE 26 6-Fluoro-2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one A solution of 6-fluoro-2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one (100 mg) in N-methylpyrrolidinone (10 ml) was treated with 4-toluenesulphonic acid monohydrate (17 mg) and 4-hydroxymethyl-5-methylimidazole hydrochloride (37 mg). The mixture was then heated to 125 for 18 h during which time three further portions of 4-hydroxymethyl-5-methylimidazole hydrochloride (37 mg) were added at 1,2 and 3 h respective. The solution was then poured into 8% sodium bicarbonate solution (100 ml) and extracted with dichloromethane (3*100 ml). The combined extracts were concentrated in vacuo and the N-methylpyrrolidinone was distilled at 100. The residue was purified by FCC eluding with System A (200:8:1) to give the title compound (100 mg), t.l.c. (System A, 100:8:1) Rf 0.3.

The synthetic route of (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride has been constantly updated, and we look forward to future research findings.

26530-93-8, name is 1-Methyl-1H-benzo[d]imidazol-6-amine, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C8H9N3

General procedure: Procedure A: The isothiocyanate compound (1 equiv) was added to the solution of amine (1 equiv) in 5 ml of a mixture of dichloromethane and acetonitrile (1:1, v/v). The mixture was cooled to 0°C. Then, triethylamine (2 equiv) was added gradually. The mixture was stirred at 0°C for 15 min, after which stirring was continued at room temperature for 2?10 h. The reaction mixture was concentrated, extracted with dichloromethane, and washed with brine.The organic layer was dried over MgSO4 and purified by column chromatography (MeOH/CH2Cl2) or by preparative TLC (MeOH/CH2Cl2) to afford the desired product.

The synthetic route of 26530-93-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 857070-66-7, name is (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol, A new synthetic method of this compound is introduced below., Safety of (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol

A mixture of m-1 (0.0273 mol) and m-2 (0.1095 mol) was stirred at 125C for 5 hours and then poured into a 10% solution OfK2CO3. The solution was saturated with K2CO3 (powder) and extracted with CH2CyCH3OH. The organic layer was separated, dried (over MgSO4), filtered and the solvent was evaporated. The residue (16 g) was purified by column chromatography over silica gel (eluent: CH2C12/CH3OH/NH4OH 88/12/0.5; 20-45 mum). The pure fractions were collected and the solvent was evaporated, yielding 5.4 g of intermediate m-3 (71%, melting point: 173C).

The synthetic route of 857070-66-7 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 108035-45-6, name is 4-(1H-Imidazol-2-yl)benzoic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 108035-45-6, category: imidazoles-derivatives

A. (4-(lH-Imidazol-2-yl)phenyI)methanol.; 4-(lH-Imidazol-2-yl)benzoic acid (2.05 g, 10.9 mmol) was suspended in anhydrous tetrahydrofuran (60 mL) and cooled to -78 0C. A solution of lithium aluminum hydride (2.0M, 21.8 mL, 43.6 mmol) was added and the reaction was allowed to slowly warm to room temperature with stirring overnight. The reaction was quenched with methanol and the crude product adsorbed onto silica gel. Flash Chromatography (20% MeOH in EtOAc) afforded the title compound (1.6 g, 9.19 mmol, 84%) as a white solid. MS (ESI) m/z 175.1 [M+ 1]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

These common heterocyclic compound, 256518-97-5, name is 2-Chloro-5-iodo-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Chloro-5-iodo-1H-benzo[d]imidazole

2-Chloro-6-iodo-1H-benzimidazole (2.34 g, 8.4 mmol), isopropylboronic acid (0.81 g, 9.2 mmol), tetrakistriphenylphosphine palladium (0.09 g, 0.08 mmol) were added to the reaction vessel. Potassium carbonate (3.48g,25.2 mmol), 60 mL of toluene, 20 mL of ethanol and 20 mL of distilled water were stirred at 120 C for 3 h. After the completion of the reaction, the reaction was quenched with distilled water, ethyl acetate was evaporated, and the organic layer was dried (MgSO4).(1.18g, 72%).

The synthetic route of 2-Chloro-5-iodo-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.