Month: May 2021

Adding a certain compound to certain chemical reactions, such as: 5098-11-3, name is 5-Amino-1H-imidazole-4-carbonitrile, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5098-11-3, Application In Synthesis of 5-Amino-1H-imidazole-4-carbonitrile

Example 19: General procedure for the preparation of (thiophene-2- carbonyl)-imidazo[1 ,5-a]pyrimidines of general formula (I) following Scheme 1. N-[3-[8-(thiophene-2-carbonyl)-imidazo[1 ,5-a]pyrimidin-4-yl]-phenyl]-N- methyl-methanesulfonamidePart A A solution of thiophen-2-yl magnesium bromide was prepared from 1.0 g ( 42 mmol) of magnesium and 6.94 g (42 mmol) of 2-bromo-thiophene in 40 ml of dry tetrahydrofuran.To the solution of the Grignard reagent, cooled by an ice-salt bath, a mixture of 1 g (9.3 mmol)of 5-amino-1 H-imidazole-4-carbonitrile and 20 ml of dry tetrahydrofuran was slowly added with stirring. After standing at room temperature for 2 hours, the mixture was cooled and decomposed by adding, with stirring, 40 ml of 3M hydrochloric acid. When the decomposition was completed (1 hour at a temperature between 90-950C), the reaction mixture EPO was basified to ph 10 with 25% ammonium hydroxide and was extracted with methylene chloride. The solution was dried with anhydrous sodium sulfate and the methylene chloride was distilled under diminished pressure to yield an oil which was chromatographied (silica gel) using ethyl acetate/methanol as eluent to produce 0.28 g (yield 16%) of (5-amino-1 H-imidazol-4-yl)- thiophen-2-yl-methanone. MS (ES) m/z = 194 (MH+)

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Adding a certain compound to certain chemical reactions, such as: 84712-08-3, name is 5-Bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84712-08-3, Product Details of 84712-08-3

Step 3: A mixture of 5-bromo-1-methyl-1H-benzo[d]imidazol-2(3H)-one (300 mg, 1.32 mmol), bis(pinacolato)diboron (403 mg, 1.58 mmol) and potassium acetate (389 mg, 3.96 mmol) in 1,4-dioxane (4.5 mL) was sparged with nitrogen while stirring for 10 min. Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) methylene chloride adduct (193 mg, 0.264 mmol) was then added and the reaction stirred at 100 C. for 1.5 h. After this time, the mixture was cooled to room temperature, partitioned between ethyl acetate and water and filtered through diatomaceous earth. The filter cake was washed with ethyl acetate and the filtrate layers separated. The organic phase was washed with water and dried over sodium sulfate. The drying agent was removed by filtration and the filtrate concentrated under reduced pressure. The resulting residue was purified by chromatography (silica, gradient, methylene chloride to 1:1 methylene chloride/ethyl acetate) to afford 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2(3H)-one (7.44).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one, other downstream synthetic routes, hurry up and to see.

Some common heterocyclic compound, 178388-79-9, name is 3-(1H-Imidazol-2-yl)propanoic acid, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3-(1H-Imidazol-2-yl)propanoic acid

4.2.1 Methyl 3-(1H-imidazol-2-yl) propanoate To a round bottom flask charged with 143 mL of methanol was added 1 g (g) (1 equiv, 7.15 mmol) of 3-(1H-imidazol-2-yl)propanoic acid (Astatech Inc.). This solution was cooled to 0 C, then 5.2 mL (10 equiv, 71.5 mmol) of thionyl chloride was added and the reaction stirred for 5 h. Upon completion, the reaction was reduced, diluted with dichloromethane, and washed three times with 0.1 M K2CO3. The organic portions were dried with sodium sulfate, filtered, and reduced to afford the HCl salt of methyl 3-(1H-imidazol-2-yl)propanoate as a white powder in quantitative yield (1.35 g, 99%). deltaH (500 MHz, DMSO-d6) 2.98 (s, 2H, CH2CH2Im), 3.16 (s, 2H, CH2CH2Im), 3.59 (s, 3H, CH3), 7.52 (s, 2H, Im), 14.58 (s, 1H, NH); deltaC (125 MHz, DMSO-d6) 20.44, 29.98, 51.45, 118.20, 145.76, 171.31; HRMS (ES+) calcd for [C7H10N2O2+H] 155.08205, found 155.08202.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 178388-79-9, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 29518-68-1, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29518-68-1, Computed Properties of C9H11N3

Example 299 7-[2-(1H-Benzoimidazol-2-yl)-ethylcarbamoyl]-heptanoic acid methyl ester (3/90) Using an analogous method (J11A), the title compound was obtained from 2-(1H-benzoimidazol-2-yl)-ethylamine (1/90) and suberic acid monomethyl ester (6c). Yield 78% (white solid). TLC: single spot at Rf 0.66 (ethyl acetate-methanol, 13:1; detection-UV-254 nm).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, other downstream synthetic routes, hurry up and to see.

Related Products of 50591-22-5, A common heterocyclic compound, 50591-22-5, name is 1-Methyl-1H-benzo[d]imidazol-5-ol, molecular formula is C8H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-methyl-1H-benzo[d]imidazol-5-ol (296 mg), methyl 4-bromo-2-fluorobenzoate (311 mg) and potassium carbonate (553 mg) were combined in dimethylsulfoxide and heated to 90 C. overnight. The reaction mixture was diluted with ethyl acetate and washed thoroughly with water and with brine, dried over MgSO4, filtered and concentrated.

The synthetic route of 50591-22-5 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 3718-04-5, These common heterocyclic compound, 3718-04-5, name is 5-Vinyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 20 (E)-2-(4-fluorophenyl)- 1 -methyl- 1 -(4-(2-(l -methyl- 1 H-imidazol-4-yl)vinyl)phenyl)- 1.2.3.4- tetrahvdroisoquinolin-6-ol and (EN)-2-(4-fluorophenvn-l-methyl-l-(4-(2-(l -methyl-lH-imidazol- 5-yl)vinyl)phenyl)-1.2.3.4-tetrahvdroisoquinolin-6-ol To a 30 mL vial, 4-vinyl-lH-imidazole (357 mg, 3.79 mmol) was dissolved in tetrahydrofuran (2 mL) and the solution was cooled to 0C. Sodium hydride (60% dispersion in mineral oil, 152 mg, 3.79 mmol) was added and the mixture was stirred for 10 min at 0C. The reaction mixture was charged with iodomethane (237 mu^, 3.79 mmol) and stirred overnight at room temperature. The reaction was quenched with saturated ammonium chloride (15 mL) and dichloromethane (25 mL) was added. The organic phase was collected, passed through a phase separator and concentrated to give crude product. Crude material was purified by silica gel chromatography (0-20% methanol/dichloromethane) to afford a mixture of 1 -methyl -4-vinyl-lH- imidazole and l-methyl-5 -vinyl- lH-imidazole (290 mg, 71% yield) as a yellow oil. NMR (400 MHz, CHLOROFORM-^ delta 3.51 (s, 3 H), 3.49 (s, 3 H), 4.97 (dd, J=11.12, 1.52 Hz, 1 H), 5.09 (dd, J=11.12, 1.01 Hz, 1 H), 5.44 (dd, J=17.68, 1.01 Hz, 1 H), 5.67 (dd, J=17.43, 1.77 Hz, 1 H), 6.25 – 6.49 (m, 2 H), 6.62 – 6.73 (m, 1 H), 7.04 (s, 1 H), 7.25 (d, J=7.58 Hz, 2 H). To a 5 mL microwave vial, l-(4-bromophenyl)-2-(4-fluorophenyl)-l-methyl- l,2,3,4-tetrahydroisoquinolin-6-ol (Intermediate Ml) (100 mg, 0.243 mmol) was dissolved in dimethylformamide (1.617 mL) and triethylamine (169 mu^, 1.213 mmol) was added. The vial was charged with a mixture of l-methyl-4 -vinyl- lH-imidazole and 1 -methyl-5 -vinyl- 1H- imidazole (1.455 mL, 0.728 mmol) and Pd(PPh3)2Cl2 (26 mg, 0.036 mmol). The system was flushed with nitrogen and heated at 150 C for 1 h under microwave radiation. The mixture was cooled to room temperature and quenched with saturated ammonium chloride. The reaction mixture was extracted three times with dichloromethane, the organic layers were combined, passed through a phase separator and concentrated to give crude material. The crude material was purified on an achiral C4 waters Atlantis Hilic 19 x 150mm 5um column with a mobile phase of 5-10% methanol with 10 mM ammonium hydroxide at a flow rate of 80 g/min to obtain (E)-2-(4- fluorophenyl)- 1 -methyl- 1 -(4-(2-( 1 -methyl- 1 H-imidazol-4-yl)vinyl)phenyl)- 1 ,2,3 ,4- tetrahydroisoquinolin-6-ol (2.4 mg, 2% yield) as a yellow solid and (E)-2-(4-fluorophenyl)-l- methyl-l-(4-(2-(l -methyl- lH-imidazol-5-yl)vinyl)phenyl)-l, 2,3 ,4-tetrahydroisoquinolin-6-ol (4 mg, 3% yield) as a white solid.

The synthetic route of 3718-04-5 has been constantly updated, and we look forward to future research findings.

Electric Literature of 6232-92-4, A common heterocyclic compound, 6232-92-4, name is 6-Nitro-1H-benzo[d]imidazol-2-amine, molecular formula is C7H6N4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Benzoyl chloride (0.51 mL, 4.4 mmol) was added to a solution of 2-amino-5-nitro-benzoimidazole (0.712 g, 4.00 mmol) in pyridine (15 mL) and the mixture was heated to 100°C for 0.5 h. Additional benzoyl chloride (0.19 mL, 1.6 mmol) was added and heating was continued for another 0.5 h. After removal of the solvent, the residue was treated with water (10 mL). The undissolved material was separated by filtration and washed with water (2 x 10 mL). After recrystallisation from pyridine (9 mL) / water (2 mL), N-(5-nitro-benzoimidazol-2-yl)benzamide (0.588 g, 2.08 mmol, 52 percent) was obtained. LC/ESI-MS: m/z = 283 [M+H]+; m/z = 281 [M-H]-; Rt =3.74 min.

The synthetic route of 6232-92-4 has been constantly updated, and we look forward to future research findings.

Application of 14840-18-7, These common heterocyclic compound, 14840-18-7, name is 3-(1H-Benzo[d]imidazol-1-yl)propanoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Oxalylchloride (2), (0.48 g, 3.52 mmol) was added to 2-benzimidazolepropionic acid (1), (0.5 g, 2.62 mmol) in a flask immersed in an ice bath, followed by the addition of few drops of DMF and 15 mL of DCM. The resulting reaction mixture was refluxed under magnetic stirring for 1 h. Then the solvent and the excess oxalyl chloride were removed by evaporation and the crude acyl derivative 3 was used immediately without further purification.

The synthetic route of 14840-18-7 has been constantly updated, and we look forward to future research findings.

Application of 64038-64-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 64038-64-8, name is Ethyl 2-mercapto-1H-imidazole-4-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 2-thioxo-2,3-dihydro-1H-imidazole-4-carboxylic acid ethyl ester (5.81 mmol) and chloroacetone (6.97 mmol) in EtOH (8.0 mL) is heated at reflux for 120 min. The solvents are removed in vacuo and POCl3 (87.1 mmol) is added. The mixture is stirred at RT for 16 h and at reflux for 4 h, concentrated in vacuo and diluted with chloroform. Ice water is added and the mixture is neutralized by addition of Na2CO3. The layers are separated and the aq. layer is extracted with chloroform. The combined organic layers are dried over Na2SO4 and concentrated in vacuo to give a crude product which is purified by CC (heptane/EtOAc 9/1 to heptane/EtOAc 3/7). LC-MS: tR=0.73 min; [M+H]+=211.0.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-mercapto-1H-imidazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14003-66-8 as follows. Formula: C4H5N3O2

EXAMPLE 4 127 parts of 4-methyl-5-nitroimidazole is heated under reflux with 350 parts of formic acid and 126 parts of dimethyl sulfate for 4 hours. The formic acid is distilled off in vacuo and the residue is dissolved in 500 parts of water and adjusted to pH 1.8 with aqueous ammonia solution. The mixture is cooled to 5 C. and the unreacted 4-methyl-5-nitroimidazole is suction filtered. The filtrate is adjusted to pH 10 with aqueous ammonia solution and is continuously exhaustively extracted with ethyl acetate. The extract is evaporated in vacuo. The oily residue crystallizes on standing. 47 parts of unreacted 4-methyl-5-nitroimidazole and 66 parts of 1,4-dimethyl-5-nitroimidazole melting at 45 C. are obtained; this is equivalent to a yield of 74% of theory.

According to the analysis of related databases, 14003-66-8, the application of this compound in the production field has become more and more popular.