Month: May 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-Methyl-1H-imidazole-2(3H)-thione

Reference Example 98 2-Cyano-6-(1-methyl-1H-imidazol-2-yl)thiopyridine 2-Mercapto-1-methyl-1H-imidazole (0.91 g, 7.94 mmol) and sodium hydride (60 % in oil, 0.35 g, 8.66 mmol) were dissolved in DMF (30 ml), and 2-chloro-6-cyanopyridine (1.05 g, 3.00 mmol) was added thereto.. The reaction mixture was stirred at 70 C for 18 hrs and combined with ethyl acetate and water.. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate.. The solvent was evaporated, and the residue was recrystallized from n-hexane-ethyl acetate to give the titled compound (1.71 g, ca. 100 %) as pale yellow crystals.1H-NMR (CDCl3) delta: 3.79 (3H, s), 7.21-7.23 (1H, m), 7.63-7.66 (1H, m), 8.85 (1H, t, J = 4.8 Hz), 8.25 (1H, d, J = 7.6 Hz), 8.56 (1H, d, J = 4.8 Hz). IR(KBr): 2231, 1570, 1550, 1433, 1373, 1167, 1152, 1086, 983, 798 cm-1.

According to the analysis of related databases, 60-56-0, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 23328-88-3 as follows. Computed Properties of C4H5BrN2

To a mixture of 5-(benzyloxy)-1,3-difluoro-2-nitrobenzene (2.65 g, 10 mmol) and potassium carbonate (2.76 g, 20 mmol) in 50 mL DMF was added 2-bromo-4-methylimidazole (1.46 g, 9.09 mmol) at RT. The resulting mixture was stirred at RT for 40 h. Majority of solvent was removed by rotavap. The residue was diluted with ethyl acetate and washed with water. Extraction with ethyl acetate, condensation on rotavap, followed by column chromatography using 20-40% ethyl acetate in hexane as eluent to provide 1.72 g (47% yield) product as a thick foam.

According to the analysis of related databases, 23328-88-3, the application of this compound in the production field has become more and more popular.

Application of 39513-26-3,Some common heterocyclic compound, 39513-26-3, name is 5-Bromo-1,3-dihydrobenzoimidazol-2-one, molecular formula is C7H5BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 5-bromo-lH-benzo[d]imidazol-2(3H)-one80 (50 mg) in dioxane (1 ml) were added pyridin-3-ylboronic acid 81 (43.3 mg), [l,l-bis(diphenyl- phosphino)ferrocene]dichloropalladium(II) (17.2 mg) and 2 M aq. sodium carbonate solution (235 mu). The reaction mixture was heated at 100 C for 18 hours. The reaction mixture was then cooled to room temperature, diluted with water (50 ml), and extracted twice with ethyl acetate (2 x 30ml). The combined organic layers were dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by chromatography (silica gel; 12 g; eluent: dichloromethane/methanol = 100/0 to 95/05 in 10 minutes) to afford 5-(pyridin-3-yl)-lH- benzo[d]imidazol-2(3H)-one (12 mg, 23%) as a red solid. MS (ISP): 212.1 ([M+H]+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-1,3-dihydrobenzoimidazol-2-one, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 73746-45-9, name is 5-Iodo-2-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Iodo-2-methyl-1H-imidazole

4-Iodo-2-methyl-1H-imidazole (5.44 g, 26.14 mmol) was addedto a suspension of sodium hydride (1.10 g, 27.4 mmol) and 18-crown-6-ether (0.691 g, 2.61 mmol) in NMP (85 mL) at 0 C. The mixture was stirred at room temperature under N2 atmosphere for 30 min. The solution of 42 (5.00 g, 27.4 mmol) in NMP(15 mL) was added dropwise to a solution of the mixture in at 0 C. The mixture was stirred at 110 C under N2 atmosphere overnight. After cooling, the mixture was poured into saturated aqueous NH4Cl solution at room temperature and extracted with EtOAc. The organic layer was separated, washed with water and brine, dried over MgSO4 and concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with10-50% EtOAc in hexane) to give 5.57 g (58%) of 43 as off-white solid. 1H NMR (300 MHz, CDCl3) d 1.42 (3H, t, J = 7.2 Hz), 2.38(3H, s), 2.66 (3H, s), 4.40 (2H, q, J = 7.2 Hz), 7.10 (1H, s), 7.12-7.19 (2H, m), 8.00-8.07 (1H, m).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52099-72-6, name is 1-(Prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 52099-72-6

Propargyl bromide(11.4 mmol) was added to a mixture of 1-isopropenyl-1H-1,3-benzimidazol-2(3H)-one 2 (5.7 mmol), potassium hydroxide(5.7 mmol) and tetra-n-butyl ammonium bromide (0.15 mmol) inCH2Cl2 (15 mL). Stirring was continued at room temperature for48 h. Salts were removed by filtration, and the filtrate wasconcentrated under reduced pressure. The residue obtained waspurified by recrystallization from ethanol to obtain colourlesscrystals in 91% yield.2.2.1.4. 1-(Prop-1-en-2-yl)-3-(prop-2-ynyl)-1H-benzimidazol-2(3H)-one: 3. Yield (%) 91;mp 331 K; 1H NMR (300 MHz, CDCl3): 2.22(d, 3H, 4JH-H 3 Hz, CH3), 2.30 (t, 3H, 3JH-H 3 Hz, CH), 4.69 (d, 2H,4JH-H 3 Hz, CH2C^CH), 5.20 (d, 1H, 4JH-H 3 Hz, CH2), 5.35 (d, 1H,4JH-H 3 Hz, CH2), 7.10e7.30 (m, 4H, CHarom). 13C NMR (75 MHz,CDCl3): 151.99 (C]O), 137.99 (Cq), 129.07 (Cq), 128.72 (Cq), 121.86(CHarom), 121.78 (CHarom), 113.32 (CH2), 109.20 (CHarom), 108.57(CHarom), 77.06(CH), 72.82 (C^CH), 30.40 (CH2), 20.22 (CH3).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52099-72-6.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 23785-21-9, name is Ethyl 1H-imidazole-4-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 23785-21-9

Synthesis of Compound 8.1. Into a 100-mL 3-necked round-bottom flask, was placed ethyl lH-imidazole-5-carboxylate (1.4 g, 9.99 mmol, 1.00 equiv) and N,N- dimethylformamide (25 mL) was added. The reaction was cooled in an ice bath and then LiHMDS (IN in tetrahydrofuran) (11 mL, 1.10 equiv) was added. The reaction was stirred at R.T. Then amino diphenylphosphinate (2.8 g, 12.01 mmol, 1.20 equiv) was added at RT. The reaction was stirred for 2 h at 25 C. Then it was concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with dichloromethane/methanol (100: 1). This provided 1.0 g (65%) of ethyl 1 -amino- lH-imidazole-5-carboxylate (8.1) as an off-white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 103057-10-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 103057-10-9 as follows.

1.1 triphenyl[[(1-triphenylmethyl)-1H-imidazol-4-yl]methyl]phosphonium chloride 77.7 g (296 mmoles) of triphenylphosphine was added to a solution of 105.5 g (294 mmoles) of 4-(chloromethyl)-1-(triphenylmethyl)-1H-imidazole in 670 ml of dimethylformamide. The resulting mixture was heated at 80 C. for three hours before being allowed to cool to room temperature. The solvent then was evaporated and the crude residue taken up in ether and triturated. The precipitate was filtered and dried under vacuum over phosphorus pentoxide to provide 162 g of the title compound in the form of yellowish crystals. Melting point=210 C. Yield=89%

According to the analysis of related databases, 103057-10-9, the application of this compound in the production field has become more and more popular.

Electric Literature of 1544-75-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1544-75-8 as follows.

[00312] lodomethane (0.82 mL, 13.15 mmol) was added to a mixture of 5-fluoro-1,3-dihydro-2H-benzimidazol-2-one (500. mg, 3.29 mmol) and potassium carbonate (1.81 g, 13.15mmol) in DMF (25 mL), and the reaction mixture stirred at ambient temperature for 16 h. DCM(30 mL) and water (60 mL) were added and the mixture stirred for 5 min. The DCM layer wasisolated by passing through a hydrophobic frit and the aqueous washed with DCM (2 x 50mL). The combined DCM extracts were concentrated under reduced pressure to yield 5-fluoro-1,3-dimethyl-benzimidazol-2-one (556 mg, 2.99 mmol, 91%).[00313] 1H NMR (300MHz, CDCI3) 5 = 6.91 – 6.71 (m, 3H), 3.42 (s, 3H), 3.41 (s, 3H)

According to the analysis of related databases, 1544-75-8, the application of this compound in the production field has become more and more popular.

Related Products of 22884-10-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22884-10-2, name is 2-(1H-Imidazol-1-yl)acetic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2.5 mL (0.029 mol) of phosphorus trichloride was added dropwise into the mixture of 1.6 g (0.013 mol) of 1H-imidazol-1-ylacetic acid (1), 2.2 g (0.027 mol) of phosphorous acid and 1.4 mL (0.008 mol) of [bmim][BF4] (A), or into the mixture of 5 mL of sulfolane and 1.4 mL (0.008 mol) of [bmim][BF4] (B) on stirring in ca. 30 min, and the contents of the flask were stirred at 75 C for 3 h. Further process including hydrolysis, pH adjustment, filtration and recrystallization was performed as described above to afford 2.9 g (75%, (A), Table 2, entry 3) and 3.6 g (93%, (B), Table 3, entry 1) of zoledronic acid dihydrate (2) in a purity of 99%. 31P NMR (D2O) delta: 17.6 and 17.3 respectively, delta[13]: 16.0.

The synthetic route of 2-(1H-Imidazol-1-yl)acetic acid has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53484-15-4, name is 5-Bromo-1-methyl-1H-benzo[d]Imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H7BrN2

A microwave vial is charged with INTERMEDIATE J, 5-bromo-l-methyl- benzimidazole (12.1 mg, 0.0574 mmol), K3P04 (37.5 mg, 0.177 mmol), PdCl2(dppf)2 (3.6 mg, 0.0044 mmol), DMF (1 mL) and heated in the microwave for 15 minutes at 120C. The mixture is filtered on Millipore and concentrated to dryness. The residue is dissolved in MeOH (2 mL), treated with NaOMe (25% w/w, 10 0.044 mmol) and stirred overnight at room temperature. The mixture is then filter on SCX-2 SPE column, the column is wash with 2M NH3 in MeOH. The filtrate is concentrated to dryness and purified by reverse phase preparative HPLC to give the title compound (5.3 mg, 28%). XH NMR (400 MHz, Methanol-d4) delta 8.15 (s, 1H), 7.88 (m, 1H), 7.80 (m, 1H), 7.60 (m, 3H), 7.45 (m, 2H), 5.04 (d, J = 3.7 Hz, 1H), 4.50 (t, J = 3.5 Hz, 1H), 3.92 (s, 3H), 3.86 (m, 2H), 3.75 (t, J = 7.9 Hz, 1H), 3.65 (dd, J = 8.0, 3.1 Hz, 1H), 3.55 (m, 1H).

The synthetic route of 53484-15-4 has been constantly updated, and we look forward to future research findings.