Month: May 2021

28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole

A mixture of 5H-benzo[d]benzo[4,5]imidazo[1,2-a]imidazole (18 g, 87 mmol), 1-bromo-3-iodobenzene (27 g, 96 mmol), Cs2CO3 (57 g, 174 mmol), L-proline (6 g, 52 mmol), Cu(I)iodide (5 g, 26 mmol) in DMSO (170 mL) was degassed with N2 for 5 min at RT, then stirred at 100 C. for overnight. After the reaction was completed, the mixture was cooled to RT, diluted with DCM, washed by water, filtered through a short pad of celite, then triturated by DCM/heptanes to give intermediate compound 1 (mixture of Br- and I-product) as off-white solid 16 g.

The synthetic route of 28890-99-5 has been constantly updated, and we look forward to future research findings.

Electric Literature of 21252-69-7, The chemical industry reduces the impact on the environment during synthesis 21252-69-7, name is 1-Octyl-1H-imidazole, I believe this compound will play a more active role in future production and life.

1,6-Dibromohexane (10.00 g, 42 mmol) was dissolved in anhydrous acetonitrile (10 mL) and introduced into a three-neck round-bottom flask. After the solution was heated gently to reflux, a solution of 1 (0.50 g, 2.80 mmol) in anhydrous acetonitrile (5 mL) was added dropwise under N2 atmosphere. The reaction mixture was stirred for 24 h at reflux and then cooled to room temperature. The solvent was removed to give a residue, which was purified by washing with anhydrous diethyl ether (35 mL), and concentrated under reduced pressure. The residue was dried under vacuum to afford 2 as a puce oil (1.01 g,85 percent). deltaH (CDCl3, 400 MHz) 10.32 (1H, s), 7.62 (1H, s), 7.50 (1H, s), 4.40 (2H, t, J 7.2), 4.34 (2H, t, J 7.6), 3.43?3.40 (4H, m), 2.03?1.84 (6H, m), 1.51?1.23 (12H, m), 0.87 (3H, t, J 6.8). deltaC (CDCl3, 100 MHz) 136.3, 122.1, 121.8, 49.9, 49.6, 33.7, 32.3,32.1, 31.5, 30.1, 30.0, 28.9, 27.2, 26.1, 25.1, 22.4, 14.0. m/z (ESI) 345 ([M]+). m/z 345.1733. HRMS (ESI) Anal. Calc. for C17H32BrN2 ([M]+) 345.1728.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Octyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 3543-72-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3543-72-4, name is Ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a clean dry flask were charged Iron powder (85 g), Cone. HCI (12.5 ml), and 625 ml of methanol and stirred for 5 minutes at room temperature. The contents were heated to 60-65 C and maintained for 2 hours. At that temperature ammonium chloride solution was charged and maintained for 15 minutes and subsequently cooled to RT. Compound II (80g) was added and then the reaction mass was maintained at 60-65 C for 2h. The mass was cooled to room temperature, filtered and distilled. To the residue was charged water and The pH adjusted to 7-8 using sodium bicarbonate solution. The Aqueous layer is extracted with ethyl acetate and the organic layer is distilled out completely to the give the title compound as a solid (60 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 152628-03-0, name is 4-Methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C12H14N2O2

Example 12Preparation of N,7-dimethyl-N-(2-nitrophenyl)-2-propyl-3H-benzo[d]imidazole-5- carboxamide (compound 15):To the mixture of 1.09 g (5 mmol) 2-propyl-3H-benzo[d]imidazole-5-carboxylic acid and 50 mi CH2Cl2, 7.26 mJ ( 100 mmol) SOCl2 was added. The mixture was stirred for 18 h and evaporated under reduced pressure.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 152628-03-0.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 23328-88-3, name is 2-Bromo-4-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 23328-88-3

To a stirred solution of 2-bromo-4-methyl-1H-imidazole (240 mg, 1.49 mmol) and cyclopropyl{4-[(2-{[6-(4,4, 5, 5-tetramethyl- 1, 3,2-dioxaborolan-2-yl )- 1 H-benzim idazol-2- yl]am ino}pyridin-4-yl)methyl]piperazin-1 -yl}methanone (150 mg, 299 iJmol) in dioxane (2.0 m L) and water (0.5 mL) was added sodium carbonate (130 mg, 1.22 mmol) and Pd(dppf)C12CHCl2 (48.8 mg, 59.7 pmol) and Tetrakis(triphenylphosphin)palladium (69.0 mg, 59.7 pmol). The mixture was heated to reflux for 24 h. Methanol was added, the mixture was filtered and the solvent was removed in vacuum. Silicagel chromatography gave 19.0 mg (13 % yield) of the title compound.LC-MS (Method 5): R1 = 2.31 mm; MS (ESIpos): m/z = 457 [M+H]1H-NMR (400 MHz, DMSO-d6) [ppm]: 0.691 (1.89), 0.711 (2.62), 0.718 (2.69), 0.731 (2.52),1.234 (0.47), 1.952 (0.59), 1.964 (0.84), 2.341 (6.66), 2.395 (0.88), 2.495 (10.55), 2.500(13.36), 2.504 (11.34), 3.169 (0.43), 3.309 (16.00), 3.565 (1.65), 3.718 (0.95), 6.986 (1.09),6.999 (1.14), 7.227 (1.50), 7.408 (1.77), 7.639 (1.33), 7.997 (2.12), 8.299 (1.25), 8.312 (1.25).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 641571-13-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, This compound has unique chemical properties. The synthetic route is as follows.

6. 3-(4-Methyl-imidazol-l-yl)-N-[4-methyl-3-(9-methyl-8-oxo-3,6,8,9- tetrahydro-S^jy^-tetraaza-cyclopentafalnaphthalen-V-y^-phenyy-S-rrifluoromethyl- benzamide; [00103] 7-(5-Amino-2-methyl-rhohenyl)-9-methyl-3,6,7,9-tetrahydro-3,4,7,9- tetraaza-cyclopenta[a]naphthalen-8-one (10 mg, 0.032 mmol) is mixed with 3-(4-methyl- imidazol-l-yl)-5-trifluoromethyl-benzoic acid (10 mg, 0.037 mmol), DIEA (0.023 ml, 0.128 mmol) and HATU (13 mg, 0.035 mmol) in 0.4 ml DMF at room temperature. After stirring at room temperature for 4 hours, the reaction mixture is concentrated and purified by RP- HPLC to afford the title compound as TFA salt (12 mg, 71%): 1H NMR 400 MHz (DMSO- dbeta) delta 11.99(5, IH), 10.61(5, IH), 9.50(5, IH), 8.53(5, IH), 8.37(m, 2H), 8.07(5, IH), 8.03(5, IH), 7.72(J, IH, J= 2.0Hz), 7.62(d, IH, J= 2.0 Hz), 7.60(4 IH, J= 2.0 Hz), 7.44(f, IH, J= 2.8 Hz), 7.28(rf, IH, J= 8.4 Hz), 6.80(?, IH), 4.84(4 IH, J= 13.2 Hz), 4.63(4 IH, J=U Hz), 3.61(5, 3H), 2.29(5, 3H), 2.05(5, 3H); MS m/z 560.2 (M + 1).

The chemical industry reduces the impact on the environment during synthesis 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 144690-33-5, name is Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate, A new synthetic method of this compound is introduced below., Product Details of 144690-33-5

Step A,Add 200.72kg to a 500L glass-lined reactorN, N-dimethylacetamide, 50.18 kg of compound (III) and6.27kg of potassium hydroxide powder, heat and stir at 40 for 1.25 hours,A compound (II) reaction solution was obtained.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3034-38-6, name is 5-Nitro-1H-imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H3N3O2

A solution of LiOH.H2O (0.84 g, 20 mmol) in MeOH (10 mL) was added dropwise to a stirred mixture of 4-nitroimidazole (2.26 g, 20 mmol) and MeOH (20 mL) at rt. After stirring (30min) the clear dark orange solution was evaporated under reduced pressure to give a solid that was dried under high vacuum to give compound 12 (2.33 g, 98%) as an orange/brown solid. mp >300 C. 1H NMR (DMSOd6,250.1 MHz): d 7.34 (s, 1H, CH), 7.89 (s, 1H, CH). 13C NMR (62.9 MHz, DMSO-d6): d 127.4 (CH), 142.7 (CH),not observed (CNO2). MS (CI) m/z (%) 112 (M-, 100).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 39021-62-0

Methyl magnesium bromide (100 ml of a 3M solution in diethyl ether, 0.30 mol) was added dropwise to a solution of 5-formyl-1-methylimidazole (14.5 g, 0.13 mol) in THF (750 ml) cooled to -20 C. such that the reaction temperature was kept below 3 C. The mixture was allowed to warm to ambient temperature and water (150 ml) was carefully added. The aqueous mixture was continuously extracted with EtOAc. The EtOAc extract was dried, and the volatiles removed by evaporation to give the title compound 14.4 g, (88%) as a solid product. NMR: 1.41 (d, 3H), 4.65-4.77 (m, 1H), 4.96-5.11 (m, 1H), 6.72 (s, 1H), 7.47 (s, 1H).

The synthetic route of 39021-62-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60-56-0, Application In Synthesis of 1-Methyl-1H-imidazole-2(3H)-thione

Aroyl chloride (1 mmol) was added to a stirred solution of ammonium thiocyanate (1 mmol) in 10 mL MeCN. The mixture was stirred at room temperature (r.t.) for 30 min. Then, 2-mercapto-1-methylimidazole (1 mmol) was added and the reaction mixture was stirred for 2 h at r.t. The solvent was removed under reduced pressure and the resulting precipitate was collected and washed with 10 mL ofcold diethyl ether to afford the pure title compounds.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-2(3H)-thione, other downstream synthetic routes, hurry up and to see.