Month: May 2021

Related Products of 4857-06-1,Some common heterocyclic compound, 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, molecular formula is C7H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of ethyl 8-oxo-9-[3-(1H-benzimidazol-2-yloxy)phenyl]-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]auinoline-3-carboxylate (I) A1. 2-Chloro-1-(tetrahydro-pyran-2-yl)-1H-benzimidazole (CAS No. 208398-29-2) A 10 l reactor is charged, under argon and with stirring, with 2.5 l of THF, 180 g of 2-chlorobenzimidazole (1.18 mol) and 325 ml of 3,4-dihydro-2H-pyran (6.56 mol, 3 eq.). The reactor is heated until dissolution occurs (temperature of the mixture: 40 C.). Then 6.3 g of para-toluenesulphonic acid (0.033 mol, 0.028 eq.) are introduced. The temperature is held at between 49 and 52 C. for 2.5 h. Cooling takes place at 12 C. and 7.65 g of sodium methoxide (0.142 mol, 0.12 eq.) are added, with stirring maintained for a total time of 15 min. The temperature is then taken to 18 C., 5 l of n-heptane are added, and the whole mixture is filtered on 300 g of Clarcel FLO-M, the retentate being washed with 5 l of n-heptane. The filtrate is concentrated to dryness under reduced pressure to give 292.6 g of 2-chloro-1-(tetrahydro-pyran-2-yl)-1H-benzimidazole in the form of a slightly yellow oil (quantitative yield). 1H NMR (400 MHz, DMSO-d6): 1.42 to 2.01 (m, 5H); 2.21 to 2.34 (m, 1H); 3.69 to 3.78 (m, 1H); 4.12 (d, J=11.4 Hz, 1H); 5.72 (dd, J=2.4 and 11.2 Hz, 1H); 7.22 to 7.34 (m, 2H); 7.82 (d. J=72 Hz, 1H); 7.78 (d, J=7.2 Hz, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-1H-benzo[d]imidazole, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1072-62-4, name is 2-Ethyl-1H-imidazole, A new synthetic method of this compound is introduced below., SDS of cas: 1072-62-4

General procedure: A vessel with a magnetic stirrer bar was charged with imidazole derivative (0.5 mmol), CuI (10 mg, 0.05 mmol), Cs2CO3 (0.33 g, 1 mmol), PPh3 (26 mg, 0.1 mmol) and tetrabutylammonium bromide (TBAB) (0.2 g, 0.6 mmol) under a nitrogen atmosphere. The reaction vessel was evacuated and backfilled with nitrogen three times. In a separate flask, a solution of dry dioxane (2 mL) containing the 1,1-dihalo-1-alkenes (1 mmol) was evacuated and back-filled with nitrogen gas three times. The dioxane solution was then added to the reaction flask via a syringe and the reaction mixture heated to 100 C for 30 hours. The reaction mixture was cooled to room temperature, quenched with 5 mL of a saturated NH4Cl solution, and extracted with ethyl acetate (3 x 10 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by flash column chromatography with ethyl acetate (EA) and petroleum ether (Pet) as the eluent to afford the corresponding products:

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 98873-55-3, name is 2-(1H-Imidazol-1-yl)acetonitrile, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 98873-55-3, Formula: C5H5N3

A 10 mL flask is charged with powdered KOH (159 mg, 2.43 mmol), DMSO (3 mL), purged with Argon and is cooled at 10CC with a water bath. A solution of 2-imidazol-1-ylacetonitrile (125 mg,1.17 mmol) and carbon disulfide (0.147 mL, 2.5 mmol) in DMSO (3 mL) is then added slowly to givean orange mixture. The cooling bath is removed and the reaction is stirred at room temperature for 30minutes. A solution of [2-bromo-1-(3-bromopyrazin-2-yl)ethyl] methanesulfonate (350 mg, 0.97 mmol)in DMSO (2 mL) is then added dropwise. After two hours, the reaction mixture is poured into H20 (15mL). The aqueous phase is extracted with dichloromethane, the combined organic phases are washedwith brine, dried with Na2504, filtered and evaporated to give a crude pale yellow residue. Purificationby chromatography on silica gel (heptanes I EtOAc, 5:1-*1:1-*1:3) afford (2E)-2-[4-(3-bromopyrazin-2-yl)-1 ,3-dithiolan-2-ylidene]-2-imidazol-1-yl-acetonitrile (Compound l.ao.25) as a yellow gum. 1HNMR(400 MHz, CDCI3): oe = 8.55 (d, J = 2.2 Hz, 1H), 8.41 (d, J = 2.2 Hz, 1H), 7.61 (s, 1H), 7.16 (s, 1H),7.03 (s, 1H), 5.67 (t, J= 5.5 Hz, 1H), 4.14 (dd, J= 5.5, 11.8 Hz, 1H), 3.91 (dd, J= 5.5, 11.8 Hz, 1H).MS (ESI): m/z= 366, 368 (M+1).

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Related Products of 87941-55-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87941-55-7, name is 4-Bromo-1-trityl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of (3-(hydroxymethyl)phenyl)boronic acid (58.6 mg, 0.3 85 mmol),4-bromo-1-trityl-1H-immdazole (100 mg, 0.257 mmol), PdC12(dppf)-DCM adduct (10 mg,0.013 mmol) and potassium carbonate (178 mg, 1.28 mmol) in 1,4-dioxane (2 mL) and water (0.5 mL) was sparged 3 times with Ar. The reaction mixture then was heated at 150C in a microwave for 30 mm. The mixture was partitioned between DCM and water. The organic layer was washed with brine. The combined aqueous layers were extracted withDCM. The combined organics were dried with Na2SO4, filtered, and concentrated. The crude was purified by flash chromatography to give 278A (89 mg, 83%) as a white solid.MS(ESI) m/z 417.2 (M+H).

The synthetic route of 4-Bromo-1-trityl-1H-imidazole has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 616-47-7, name is 1-Methyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1-Methyl-1H-imidazole

D preparation of ionic liquid: in the flask to three N-methyl imidazole, slowly dropping equimolar 1, 4-propane sulfur lactone, stirring, reaction 24h, filtered, to obtain white precipitation, washing by acetone, vacuum drying to obtain intermediate; then the intermediate in adding three-mouth flask, dropping equimolar concentrated sulfuric acid, with ethyl acetate as the solvent, the temperature is increased to 70 C reflux reaction mixing 48h, then ethyl acetate for washing, d vacuum drying to obtain the ionic liquid.

The synthetic route of 616-47-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 56248-10-3, A common heterocyclic compound, 56248-10-3, name is 5-Phenyl-1H-imidazole-2-carbaldehyde, molecular formula is C10H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of compound 3 (100mg, 0.40 mmol) in ethanol was added corresponding benzohydrazides (4a-m) (1.0 mmol) and refluxed for 1 h. The reaction mass was washed with pet ether, filtered and dried undervacuum to obtain the pure hydrazone compounds. Yields ofthe products varied between 78 and 88 %.

The synthetic route of 56248-10-3 has been constantly updated, and we look forward to future research findings.

4887-94-9, name is 2-Chloro-5-methyl-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Chloro-5-methyl-1H-benzo[d]imidazole

10 g of 2-chloro-5-methyl-1H-benzo[d]imidazole was added to 130 ml of N,N-dimethylformamide,Add 15g of anhydrous potassium carbonate and 9g of piperidine-4-carboxylic acid,Heated at reflux for 2 hours,cool down,Add water and ethyl acetate extractionLiquid separation,Collect the organic phase,concentrate,The residue was separated on a silica gel column to give 7 g of 1-(5-methyl-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylic acid.

The synthetic route of 4887-94-9 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1849-01-0, A common heterocyclic compound, 1849-01-0, name is 1-Methyl-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C8H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Scheme 15: (1264) (1265) To a THF solution (2 mL) of 15-1 (100 mg, 674 mumol) was added NaH (13.4 mg, 337 mumol) under Nitrogen atmosphere. The resultant solution was heated at 60oC for 30 minutes. To the hot reaction mixture was added a THF solution (2 mL) of 2-1 (64.7 mg, 337 mumol) drop wise and the heating was continued for another 5 hours to produce Compound 176. It was then cooled to room temperature, diluted with 20% IPA-DCM solution, washed with water and brine. The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. Crude mass was purified by column chromatography (silica, gradient: 0-3% MeOH in DCM) to afford Compound 176 (3.5 mg, 13 mumol, 5%). 1H NMR (400 MHz, DMSO-d6) delta 11.10 (s, 1H), 7.19 (d, J = 7.6 Hz, 1H), 7.15- 7.01 (m, 3H), 5.38 (s, 1H), 3.25 (s, 3H), 2.90-2.87 (m, 1H), 2.72-2.50 (m, 2H), 2.07-2.05 (m, 1H). LC MS: ES+ 260.3.

The synthetic route of 1849-01-0 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 150058-27-8, These common heterocyclic compound, 150058-27-8, name is Methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 500 mL flask was added 200 mL of acetone,Ethoxybenzimidazole-7-carboxylate (XIII, 22.0 g,0.10 mol),K2CO3 (17.9 g, 0.13 mol) and 4-bromomethyl-2′-cyanobiphenyl (28.6 g, 0.105 mol).The temperature was raised to reflux and reaction was complete until TLC disappeared (about 5 to 8 hours).

The synthetic route of 150058-27-8 has been constantly updated, and we look forward to future research findings.

Reference of 75370-65-9, A common heterocyclic compound, 75370-65-9, name is 4-Amino-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C7H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of 1-(4-chloro-2-(dimethylamino)benzyl)-3-(2,3-dihydro-2-oxo-1H-benzo[d]imidazol-4-yl)urea Amine 2af (1 g, 5.5 mmol) was dissolved in 20 ml of AcOEt and at 0C triphosgene (1.63 g, lequiv.) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 10ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound 1a (820 mg, 5.5 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt). The solvent was evaporated and the crude was dissolved in AcOEt (30 ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 550mg of a white solid. Yield = 28% 1HNMR (DMSO, 200 MHz) delta 2.64 (6H, s), 4.34 (2H, d, J = 5.8 Hz), 6.62 (1H, dd, J = 7.2 Hz, J’ = 1 Hz), 6.73 (1H, t), 6.83 (1H, t, J = 7.6 Hz), 6.90 (1H, dd, J = 8.2 Hz, J’ = 1Hz), 7.06 (2H, m), 7.31 (1H, d, J = 8.8 Hz), 8.33 (1H, bs), 9.98 (1H, bs), 10.59 (1H, bs); [M+1] 360.7 (C17H18ClN5O2 requires 359.81).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.