Month: May 2021

Synthetic Route of 10394-38-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10394-38-4, name is 1-Methylbenzoimidazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows.

10.2 N-(1-methyl-benzimidazol-5-yl)-5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamide A solution of 0.32 g (0.95 mmol) of 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylic acid, obtained in step 10.1, and 0.69 ml (9.49 mmol) of thionyl chloride in 25 ml of dichloromethane is refluxed for 2 hours. The mixture is concentrated under reduced pressure, the residue is taken up in 20 ml of diethyl ether, and 0.17 g (1.14 mmol) of 5-amino-1-methylbenzimidazole and a solution of 0.2 g (1.9 mmol) of sodium carbonate in 2 ml of water are added. The mixture is stirred for 24 hours at room temperature, the organic phase is evaporated under reduced pressure and the resulting phase is extracted with ethyl acetate and dichloromethane. The organic phases are washed with water and with saturated sodium chloride solution, dried over sodium sulfate and concentrated under reduced pressure. The residue is taken up in petroleum ether, collected by filtration, washed and dried under reduced pressure. It is then purified by chromatography on a column of silica gel, eluding with a mixture of dichloromethane and ethyl acetate. The residue is taken up in petroleum ether, collected by filtration, washed and dried under reduced pressure. 0.3 g of solid is obtained. Melting point: 223-224 C. 1H NMR (DMSO), delta (ppm): 5.9 (s, 2H); 7 (m, 3H); 7.3 (m, 1H); 7.55 (m, 4H); 7.8 (d, 1H); 8.05 (s, 1H); 8.1 (d, 2H); 10.5 (s, 1H).

The chemical industry reduces the impact on the environment during synthesis 1-Methylbenzoimidazol-5-amine. I believe this compound will play a more active role in future production and life.

These common heterocyclic compound, 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H4N2O4

The complex was synthesized by hydrothermal method. A mixture of Zn(NO3)2.6H2O (0.47 g; 1.6 mmol), H3idc (0.25 g, 1.6 mmol) and water (30 mL) was sealed in a 45 mL Parr brand teflon-linedacid digestion bomb and heated at 180 C for 5 days, and then cooled to room temperature at a rate of 5 C/h. Pale yellow crystals of 1 were obtained (yield: 0.195 g, 73% based on Zn(NO3)26H2O). Anal. Calc. for C10H2N4O8Zn3: C, 23.91; H, 0.40; N, 11.15. Found:C, 23.90; H, 0.52; N, 10.90%. IR data (KBr, cm1): 3531m, 3359m, 3120m, 1589s, 1544s, 1474s, 1477s, 1384s, 1296m, 1253s, 1205m, 1107s, 1020w, 871m, 835m, 792m, 661m, 540w.

The synthetic route of 1H-Imidazole-4,5-dicarboxylic acid has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6775-40-2, name is 5-Phenyl-1H-imidazol-2-amine, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Phenyl-1H-imidazol-2-amine

General procedure: The mixture of corresponding 2-amino-4-arylimidazoles 1 (1.0 mmol), isatin 18 (1.0 mmol) andmalononitrile 12 (1.0 mmol) in 2 mL of 2-propanol was refluxed during 50-60 min. After cooling, the solid products 19 were filtered off and crystallized from iPrOH.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 4887-88-1,Some common heterocyclic compound, 4887-88-1, name is 5-Bromo-1H-benzo[d]imidazole, molecular formula is C7H5BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 5-bromo-1 H- benzimidazole (43.78 g, 222.0 mmol) in chloroform (800 mL) was added N-methylimidazole (44.5 mL, 560.0 mmol), followed by methyl 2-chloro-3-oxo-2,3-dihydro-2-thiophenecarboxylate (44.8 g, 233.0 mmol). The reaction was stirred 20 h at room temperature, then N- methylimidazole (18.0 mL, 226.0 mmol) was added, followed by X- butyldimethylsilylchloride (36.8 g, 245.0 mmol). The reaction was stirred 1 hr, then quenched with MeOH and poured into DCM and water. The aqueous layer was extracted with DCM (3x). The combined organics were then dried over Na2SO4, concentrated and chromatographed on silica gel, eluting with a 50-to-75% gradient of 25% EtOAc in hexane/hexane to give 25.18 g (24%) of the title compound. MS (ESI): 467 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-1H-benzo[d]imidazole, its application will become more common.

These common heterocyclic compound, 120781-02-4, name is Methyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H7BrN2O2

1 g (4.565 mmol) of methyl 1-methyl-2-bromoimi- dazole-5-carboxylate (Vu-i) was dissolved in 10 ml of ethanol, 5.48 ml of iN NaOH (aq.) was added and the mixture was stirred at room temperature for 60 mm. After addition of 5.5 ml of iN HC1 (aq.) (adjusted to pH .-3), a white precipitate is formed. The mixture was concentrated to dryness and, in an ultrasonic bath, suspended in 6 ml of watet The white crystals were filtered oil and washed with 2 ml of water. The mother liquor was concentrated almost to dryness. The crystals were filtered off with suction and washed with a little watet The combined crystals were dried under oil pump vacuum. Yield: 890 mg (95% of theory).log P[a]: 0.31; ?H-NMR (d5-DMSO, 400 MHz); oe=3.82 (s, 3H),7.60 (s, 1H), 13.15 (s, 1H) ppm.

The synthetic route of Methyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., Recommanded Product: 641571-11-1

A mixture of 46 (100 mg, 0.39 mmoi) and LiOH (28 mg, 1.17 mmoi) in THF/H20 (2/1 mL) was stirred at room temperature for 8 hours. TLC indicated the reaction was compiete. The reaction mixture was diiuted with water and acidified to pH 3 with aqueous HCi. The resuiting precipitate was fiitered washed with water and dried to give 47 (90 mg, 95%) as a white soiid. To a soiution of 47 (100 mg, 0.41 mmoi) in NMP (1 .5mL) was added SOCi2 (74 mg, 0.62 mmoi). The reaction was heated at 60 C for 1 hour before 3 (100 mg, 0.41 mmoi) and Et3N (166 mg, 1 .64 mmoi) were added. The resuiting mixture was stirred at 60 C for 3 hours. The reaction was directiy purified by reverse prep-H PLC and then siiica gei prep-TLC to give 3-(benzyioxy)-4-methyi-N-(3-(4-methyi- 1 H-imidazoi-1 -yi)-5-(trifiuoromethyi)phenyi)benzamide (25 mg, 13%) as a white soiid.

The synthetic route of 641571-11-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 16042-25-4, name is 2-Imidazolecarboxylic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16042-25-4, Product Details of 16042-25-4

General procedure: The syntheses of 1-5 followed a similar procedure. In thesynthesis of 1, CoCl2*2H2O (0.0129 g, 0.100 mmol) and 2-Htza(0.0129 g, 0.100 mmol) were dissolved in distilled water(5.0 ml). The solution was left undisturbed at room temperaturefor several days, from which 1 crystallized. The sameprocedure was adopted for the syntheses of 2 and 3, exceptthat NiCl2*2H2O (0.0129 g, 0.100 mmol) and Cd(NO3)2*4H2O(0.0129 g, 0.100 mmol), respectively, were used instead ofCoCl2*2H2O. The procedure was also applied for the preparationof 4 and 5, except that Co(NO3)2*6H2O (0.0290 g,0.100 mmol) was used as a metal salt, whereas 2-H2ima(0.0112 g, 0.100 mmol) and 4-Hoxa (0.0113 g, 0.100 mmol)were used as the ligands for the preparation of 4 and 5,respectively.

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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 5-Nitro-1H-benzo[d]imidazol-2(3H)-one

Intermediate 301 was prepared from 5-nitro-1,3-dihydro-2H-benzo[d]imidazol-2-one 10 (CAS: 984-5) and bromoacetamide (CAS: 683-57-8) by the method indicated in the scheme below:

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 93-84-5.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 124750-92-1 as follows. Computed Properties of C22H21ClN6O2

To a 100 ml of one-necked flask, 4.36 g of 2-butyl-4-chloro-1-[2′-(1H-tetrazol-5-yl)1,1′-biphenyl-methyl]imidazole-5-carboxylic acid, 15 ml of N,N-dimethylformamide, 1.66 g of potassium carbonate and 2.78 g of triphenylchloromethane were added in turn. The mixture was reacted at room temperature overnight. The reaction was stopped and 100 ml of water was added. The resulting mixture was extracted with 100 ml of ethyl acetate and washed once by saturated brine. The organic phase was dried and concentrated to give 7.5 g of 2-butyl-4-chloro-1-[2′-(1-triphenylmethyl-tetrazol-5-yl) 1,1′-biphenyl-methyl]-imidazole-5-carboxylic acid as a yellow oil. The crude product obtained from this example was used as material referred to in the following examples without purification.

According to the analysis of related databases, 124750-92-1, the application of this compound in the production field has become more and more popular.

Synthetic Route of 39021-62-0,Some common heterocyclic compound, 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 54-(2-Chloro-11 -fhvdroxy-(3-methyl-3H-imidazol-4-yl)-methvn-dibenzofa,d1cvclohepten- 5-ylidene)-piperidine-1 -carboxylic acid tert-butyl ester 4-(11 -Bromo-2-chloro-dibenzo[a,d]cyclohepten-5-ylidene)-piperidine-1 – carboxylic acid tert-butyl ester (2.5 gm, 5.1 mmol) was dissolved in dry tetrahydrofuran. Cooled to -78 C under a nitrogen atmosphere. Driped in a solution of 2.5M nBuLi in hexanes (3.25 ml) and stir 15 minutes. Added a tetrahydrofuran solution of 3-Methyl-3H-imidazo.e-4-carbaldehyde (0.56 gm, 5.1 mmol) quickly and stirred at -78 C. Let warm up to room temperature slowly and stired 20 tirs. Added to brine and extracted with 3X 100 ml of ethylacetate. Combined the ethylacetate extracts, dried over magnesium sulfate, filtered and evaporateed to a solid. Chromatographed on silica gel using 3%-5% methanol/dichloromethane to obtain 1.09 gm of pure title product. ESI M+1= 519

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-5-carbaldehyde, its application will become more common.