Month: May 2021

Synthetic Route of 14741-71-0, The chemical industry reduces the impact on the environment during synthesis 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, I believe this compound will play a more active role in future production and life.

Example 64: Synthesis of 2-(2-Morpholin-4-yl-ethylamino)-l,7,llb-triaza- benzo[c]fluorene-6-carboxylic acid ethyl ester (Compound 11A) [0348] To a solution of compound SMI (147 mg) and compound SM2 (204 mg) in ethanol (10 mL) was added 2-Morpholin-4-yl-ethylamine (1 mmol) and the mixture was stirred at room temperature for 20 min. The reaction mixture was heated to reflux for 16h. After cooling, the mixture was filtered and washed with ethanol, dried to get compound 11 A as yellow solid (340 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, other downstream synthetic routes, hurry up and to see.

Application of 96797-15-8, These common heterocyclic compound, 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[275] To an ice-salt bath cooling solution of 4-iodo-1-trityl-1H-imidazole (2.5 g, 5.7 mmol) in dichloromethane (DCM) (30 mL) was added ethylmagnesium bromide (2.5 mL, 7.5 mmol, 3.0 M solution in diethyl ether) slowly. The resulted mixture was stirred at roomtemperature for lh, then added chlorotributyltin (2.6 g, 8.0 mmol). The resulted mixture was stirred at room temperature for 2h, then added saturated ammonium chloride solution (50 mL), the mixture was extracted with dichloromethane (100 mLx2). The combined organic phase was washed with brine (25 mL), dried over sodium sulfate, filtered and concentrated. The residue was recrystallization with a mixed solvent (petroleum ether: ethyl acetate= 6:1) toafford 4-(tributylstannyl)-1-trityl-1H-imidazole (2.6 g, yield: 76%) as a white solid.[276] m/z: [M+H] 601

Statistics shows that 4-Iodo-1-trityl-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 96797-15-8.

Application of 51605-32-4, The chemical industry reduces the impact on the environment during synthesis 51605-32-4, name is Ethyl 5-methyl-1H-imidazole-4-carboxylate, I believe this compound will play a more active role in future production and life.

(1) Ethyl 4-methyl-1H-imidazole-5-carboxylate (7.5 g, 48.7mmol) was dissolved in acetonitrile (120 mE), N-bromosuccinimide (10.4 g, 58.4 mmol) was added thereto, and then themixture was stirred at room temperature for 3 hours. Afier thereaction, saturated aqueous sodium hydrogen carbonate wasadded and the mixture was extracted twice with ethyl acetate.Afier washing with saturated aqueous sodium chloride, theorganic layer was dried over anhydrous sodium sulfate. Afterconcentrating the organic layer, the residue was purified bycolunm chromatography to obtain ethyl 2-bromo-4-methyl-1 H-imidazole-5-carboxylate (3.6 g):(3H, s), 1.37 (3H, t, J=7.i Hz);j0127] iH.NMR (CDC13) oe: 4.35 (2H, q, J=7.i Hz), 2.51j0128] ESI-MS mlz=233 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-methyl-1H-imidazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Application of 1072-62-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1072-62-4 name is 2-Ethyl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of the appropriate bromoacetophenone 1 or 2 (0.500mmol), appropriate benzimidazole or imidazole (0.750 mmol), andsodium acetate (49.2 mg, 0.600 mmol) in tetrahydrofuran (3 ml)was stirred at room temperature for 24 h. The reaction mixturewas poured into water. The precipitate was filtered off, washedwith water, and then with diethyl ether.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Ethyl-1H-imidazole, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10111-08-7, name is Imidazole-2-carboxaldehyde, A new synthetic method of this compound is introduced below., name: Imidazole-2-carboxaldehyde

a) 1.5 g of 2-imidazole carboxaldehyde was dissolved in 20 ml of dimethylformamide, 2.18 ml of triethylamine and 4.3 g of triphenylmethyl chloride were added to the above solution, and then the resulting mixture was stirred at room temperature for 24 hours. A saturated sodium bicarbonate aqueous solution and chloroform were added to the reaction solution, and the resulting organic layer was collected, washed with a saturated aqueous sodium chloride solution and then dried over anhydrous sodium sulfate, followed by evaporation of the solvent. The residue was subjected to silica gel chromatography eluted with dichloromethane-methanol (50:1) to obtain 4.717 g of 1-triphenylmethyl-2-imidazole carboxaldehyde. Mass spectrometry value (m/z): 339 (M+ +1) Nuclear magnetic resonance spectrum (CDCl3, TMS internal standard) delta: 7.02-7.51 (17H, m), 9.23 (1H, s)

The synthetic route of 10111-08-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (200 mg, 0.483 mmol, 1.0 equiv),Compound (2-(Diphenyl[b,d]furan-2-yl)-2-oxoethyl)phosphoric acid dimethyl ester (0604-96) (170 mg, 0.53 mmol, 1.1 eq) andCesium carbonate (315 mg, 0.966 mmol, 2.0 equiv)Mixed in isopropyl alcohol (30 ml),The reaction was stirred at room temperature overnight. After the reaction is over, add water andSolids precipitated, filtered and the cake was dried to give the product 1-(diphenyl[b,d]furan-2-yl)-3-(2-(1-trityl-1H-)Imidazol-4-yl)phenyl)prop-2-en-1-one (300 mg, crude).

The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 6478-73-5, name is 5,6-Dichloro-1H-benzo[d]imidazole, molecular formula is C7H4Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 6478-73-5

Step B: 2-[(S)-1-Phenylethylamino]-4-[5,6-dichlorobenzimidazol-1-yl]pyrimidine To a solution of 100 mg of 5,6-dichlorobenzimidazole in 3 mL of DMF was added 26 mg of NaH (60% dispersion in oil) and the resulting suspension was stirred at room temperature for 15 minutes. Then, 138 mg of 2-[(S)-1-phenethylamino]-4-chloropyrimidine (EXAMPLE 117) was added and the reaction was heated to 100 C. for 3 hours. After cooling to room temperature, the solution was then diluted with 10 mL of H2O and extracted with 2*10 mL EtOAc. The organic phases were then dried over MgSO4 and concentrated under reduced pressure. The residue was purified with preparatory thin-layer chromatography (SiO2, 5% MeOH in CH2Cl2) to yield 205 mg of the title compound as a yellow oil. RF: 0.63 (5% MeOH in CH2Cl2). 1H NMR (500 MHz, CD3OD): delta 8.89 (br S, 1H), 8.36 (s, 1H), 7.86 (s, 1H), 7.74-7.45 (m, 2H), 7.32-7.28 (m, 3H), 7.19 (t, 1H, J=7.0 Hz), 6.99 (d, 1H, J=5.5 Hz), 5.19 (q, 1H, J=7.0 Hz), 1.59 (d, 3H, J=7.0 Hz). Mass Spectrum (ESI) 384 (M+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6478-73-5, its application will become more common.

Electric Literature of 214147-60-1, These common heterocyclic compound, 214147-60-1, name is tert-Butyl 2-chloro-1H-benzo[d]imidazole-1-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step B: 2-(2, 6-Dimethyl-phenoxy)-lH-benzoimidazole; Cesium carbonate (2.643 g, 8. 112 mmol) was added to a solution of 2-chloro- benzoimidazole-l-carboxylic acid tert-butyl ester (1.000 g, 3.957 mmol) and 2,6- dimethylphenol (3. 867 g, 31.66 mmol) in isopropanol (10 mL). The mixture was heated at 150 C for 22 h and then cooled to room temperature. The reaction mixture was partitioned between ethyl acetate and 2.0 N sodium hydroxide solution. The aqueous phase was separated and extracted with ethyl acetate and dichloromethane. The combined organic phases were washed with brine, dried over anhydrous magnesium sulfate, filtered, and concentrated to afford an orange-brown solid. Trituration with dichloromethane and filtering afforded 2- (2, 6-dimethyl- phenoxy)-lH-benzoimidazole as an off-white solid. MS (MH+) 239.2 ; Calculated 238.11 forCl5Hl4N2O.

The synthetic route of 214147-60-1 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20075-26-7, name is 1-(Methoxymethyl)-1H-imidazole, A new synthetic method of this compound is introduced below., name: 1-(Methoxymethyl)-1H-imidazole

Step B. N-Methyl-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(1-methoxymethyl-1H-imidazol-2-yl)-ethyl]-phenyl}-benzenesulfonamide To a solution of 55 mg (0.49 mmol) of 1-methoxymethyl-1H-imidazole in 5 ml of THF at -78 C. was added 0.20 ml (0.50 mmol) of a 2.5 M solution of n-butyllithium in hexanes and the resultant mixture was stirred at -78 C. for 30 mins.After this time, a solution of 160 mg (0.47 mmol) of N-methyl-N-(4-trifluoroacetyl-phenyl)-benzenesulfonamide (Example 22, Step A) in 2 ml of THF was added and the resultant mixture stirred at -78 C. for a further 2 h, and then at room temperature for 14 h.After this time the reaction was quenched by the addition of a saturated aqueous solution of ammonium chloride and extracted with EtOAc. The combined organic layers were washed with brine, dried over MgSO4, filtered and the filtrate was concentrated.The residue was purified by chromatography on silica gel (hexanes:EtOAc, 4:1) to give the title compound. 1H-NMR (CDCl3) delta 3.09 (s, 3H), 3.19 (s, 3H), 4.90 (s, 2H), 5.16 (brs, 1H), 7.07-7.16 (m, 4H), 7.42-7.62 (m, 7H).Mass Spectrum (CI+) m/e=456.1 (M+1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 2302-25-2, name is 4-Bromo-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2302-25-2, Product Details of 2302-25-2

(iv) Production of (2,3-Dihydronaphtho[2,3-b]furan-6-yl)(1H-imidazol-4-yl)methanol A solution of 4-bromo-1H-imidazole (2.11 g) in THF (40 ml) was cooled to -78 C. A solution of tert-butyllithium in pentane (1.7 M; 13 ml) was added to the solution. The mixture was stirred at 5 C. for 2 h and then cooled to -78 C. 6-formyl-2,3-dihydronaphtho[2,3-b]furane (1.46 g) in THF (30 ml) was added to the mixture. The mixture was allowed to room temperature and was stirred for 20 h. Ammonium chloride solution was added to the mixture and extracted with mixed solution of THF and ethyl acetate. The organic layer was dried and concentrated. The residue was purified by silica gel chromatography to give the titled compound (1.01 g) as a colorless solid. 1H-NMR (DMSO-d6) delta: 3.33 (2H, t, J=8.2 Hz), 4.59 (2H, t, J=8.2 Hz), 5.79 (1H, s), 6.79 (1H, s), 7.07 (1H, s), 7.40 (1H, d, J=8.8 Hz), 7.57 (1H, s), 7.65 (1H, d, J=8.8 Hz), 7.70 (1H, s), 7.76 (1H, s). IR (KBr): 3069, 1460, 1229, 1028, 886, 839 cm-1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1H-imidazole, and friends who are interested can also refer to it.