Month: May 2021

Synthetic Route of 41806-40-0, The chemical industry reduces the impact on the environment during synthesis 41806-40-0, name is 1-Methylimidazole-5-carboxylic Acid, I believe this compound will play a more active role in future production and life.

To a solution of 1-methyl-1 H-imidazole-5-carboxylic acid (45 mg, 0.36 MMOL) in DICHLOROMETHANE (3.6 mL) was added 6-CHLORO-2, 3,4, 9-tetrahydro-1H-carbazol-1- amine (95 mg, 0.43 MMOL), 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide (83 mg, 0.43 MMOL), and 1-hydroxybenzotriazole (54 mg, 0. 40 MMOL). After 5 minutes, triethylamine (100 muL, 0.72 MMOL) was added and the reaction was stirred at room temperature for 15 hours. The reaction mixture was diluted with dichloromethane, washed with water, 1 N hydrochloric acid, 1 N sodium hydroxide, brine, dried with magnesium sulfate, filtered, and concentrated. The residue was purified by PREPARATIVE chromatography (10-90% acetonitrile-water (0. 1% trifluoroacetic acid) ) and then diluted with ethyl acetate, washed with saturated aqueous sodium bicarbonate, and dried with magnesium sulfate to give 43 mg (36% yield) of a white SOLID. H-NMR (CDCI3) : 8 9.21 (s, 1H), 7. 43 (M, 1H), 7. 32 (s, 1H), 7. 30 (s, 1H), 7. 20 (d, 1H), 7.07 (dd, 1H), 6. 60 (d, 1H), 5.25 (m, 1H), 3. 81 (s, 3H), 2.67 (m, 2H), 2. 21 (m, 1H), 1.90 (m, 3H) ; MiS m/z 327 (M-1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methylimidazole-5-carboxylic Acid, other downstream synthetic routes, hurry up and to see.

Reference of 670-96-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 670-96-2, name is 2-Phenyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

[0003081 To a stirred solution of compound 1 (2 g, 1 eq) in Conc. H2S04 (8 mL), nitrating mixture (0.88 mL Conc. HN03 + 2 mL Conc. H2S04) was added at 0 C and stirred at same temperature for 2 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was poured onto ice water and basified to pH 9 using 2N NaOH. The precipitated solid was filtered, washed with water and dried under reduced pressure to afford the title compound 2. LCMS (mlz): 190.00 (M + 1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Phenyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Related Products of 27231-33-0, A common heterocyclic compound, 27231-33-0, name is 4-Methyl-1H-benzo[d]imidazole-2(3H)-thione, molecular formula is C8H8N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 20 2,3-Dihydro-5-methyl-2-(2-pyridyl)thiazolo[3,2-a]benzimidazole 4-Methyl-2-mercaptobenzimidazole (13.32 g) was suspended in 2-methylpropan-2-ol (150 ml) and potassium tertbutoxide (9.04 g) added. The mixture was stirred for 2 hours and 2-(1,2-dibromoethyl)pyridine hydrobromide (27.68 g) added. The mixture was stirred at ambient temperature for 1 hour and then at reflux for 2 hours. The reaction mixture was filtered and the solid washed with ether. The filtrate was evaporated to dryness under reduced pressure and the residue combined with the first solid obtained. The combined material was dissolved in 2N HCl (100 ml). The aqueous solution was extracted with ethyl acetate, basified (Na2 CO3) and extracted with dichloromethane. The organic layer was dried (MgSO4) and the solvent removed under reduced pressure. The residue was purified on Florisil using chloroform as eluent and on silica using ethyl acetate as eluent to give the title compound (1.55 g) mp 128-130 C. Analysis: Found: C, 67.1; H, 5.0; N, 16.1. C15 H13 N3 S requires: C, 67.4; H, 4.9; N, 15.7%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40197-20-4, name is 5-Bromo-1H-benzo[d]imidazole-2-carboxylic acid, A new synthetic method of this compound is introduced below., category: imidazoles-derivatives

A mixture of 5-bromo-1H-benzimidazol-2-carboxylic acid (3.0 g), tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate (7.7 g), dichloro[1,1?-bis(di-tert-butylphosphino)ferrocene]palladium (410 mg), 2 M aqueous sodium carbonate solution (50 ml), and dioxane (75 ml) was stirred at 95 C. overnight in an argon atmosphere, and then cooled to room temperature. After water (170 ml) and ethyl acetate (200 ml) were added to the reaction mixture, the reaction mixture was stirred for 20 minutes, and then subjected to liquid-liquid partition. The aqueous layer was washed with ethyl acetate (50 ml), and then citric acid was added thereto to adjust pH to be 6 to 7. The resulting solid was collected by filtration, and then dried under reduced pressure, thereby obtaining 5-[1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-benzimidazole-2-carboxylic acid (2.7 g) as a solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 1072-84-0, These common heterocyclic compound, 1072-84-0, name is 1H-Imidazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1H-Imidazole-4(5)-carboxylic acid (0.560 g, 5 mmol) was dissolved in DMF (20 mL) and a small amount of insoluble solid was filtered off. A cooled (0 C) solution of diazomethane in ether36 was added until no more bubbles were formed. After evaporation of the solvent under reduced pressure the residue was dissolved in ether and washed with water to neutral pH. Then the ethereal solution was dried and evaporated. The product was obtained as a white solid homogeneous by TLC in 40% yield (0.252 g); mp 144-147 C (mp.lit37 = 153-154 C).1H NMR (CD3OD) delta: 7.77(d, J = 4.5 Hz, 2H, NCHNHCH), 3.85(s, 3H, CH3).13C NMR delta: 164.2(COO), 138.6, 126.6, 123.4, 52.0(CH3).Anal. Calcd for C5H6N2O2: C, 47.62; H, 4.80; N, 22.21. Found: C, 47.58; H, 4.96; N, 22.12.

The synthetic route of 1072-84-0 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 5993-91-9, name is (1H-Benzo[d]imidazol-2-yl)methanamine dihydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of (1H-Benzo[d]imidazol-2-yl)methanamine dihydrochloride

a Methyl (+-)-7-[[[(2-benzimidazolyl)methyl]amino]carbonyl]-4-methyl-3-oxo-2,3,4,5 -tetrahydro-1H-1,4-benzodiazepine-2-acetate A mixture of methyl (+-)-7-carboxy-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2-acetate (0.57 g, 1.82 mmol) and thionyl chloride (15 mL) was refluxed for 1 h. The resulting orange solution was concentrated to dryness to leave a yellow-orange foam. This was dissolved in CH2Cl2 (10 mL) and added dropwise to a solution containing 2-(aminomethyl)benzimidazole dihydrochloride (1.2 g, 5.46 mmol), pyridine (0.72 g, 9.1 mmol), and triethylamine (0.55 g, 5.46 mmol) in CH2Cl2 (15 mL) at 0 C. under argon. The reaction mixture was then stirred in RT under argon. After 25.5 h, CH2Cl2 (200 mL) and 5% NaHCO3 (50 mL) were added to the reaction mixture to give a light yellow precipitate which was filtered and air-dried to give the title compound (0.11 g, 14%). The filtrate was separated and the organic layer was washed sequentially with 5% NaHCO3 (50 mL) and H2O (50 mL), then was concentrated on the rotavap. After trituration with CH2Cl2 and air-drying, a yellowish solid was collected to yield more of the title compound (0.35 g, 45%).

The synthetic route of (1H-Benzo[d]imidazol-2-yl)methanamine dihydrochloride has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 17289-26-8, name is 1-Methyl-1H-imidazole-4-carbaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17289-26-8, category: imidazoles-derivatives

To a solution of 15 (1.01 g, 9.18 mmol) in dry THF (10 mL) were added 5a (3.35 g. 10.1 mmol, 1.1 eq)and TMG (1.7 mL, 13.8 mmol, 1.5 eq) at 0 C, and the mixture was stirred for 24 h at rt. The reaction mixture was quenched with water and acidified with 1N aqueous HCl, and extracted with CH2Cl2. The aqueous layer was neutralized with sat. aqueous NaHCO3 and extracted with CH2Cl2. The combined organic extracts wered ried over anhydrous MgSO4, concentrated in vacuo to afford the crude product. The residue was purified by silica gel flash column chromatography (40:1 CHCl3 / MeOH). The obtained residue was washed with Et2O and the cake was dried in a house vacuum oven to afford 11a (1.90 g, 65%) as a white solid. IR (solid, cm-1) 1063, 1225, 1273, 1462, 1728, 2951, 32291H NMR (500 MHz, CDCl3) delta 3.68 (s, 3H), 3.79 (s, 3H), 5.18 (s, 2H), 6.56 (s, 1H), 6.95 (s, 1H), 7.31-7.43 (m,6H)13 C NMR (125 MHz, CDCl3) delta 33.5, 52.2, 67.1, 112.9, 121.4, 126.6, 128.0, 128.1, 128.4, 136.2, 137.7, 154.1,165.8FAB-MS : m/z 316 (M+H)+HRMS (ESI) Calculated for C16H18N3O4 316.1291 Found 316.1299

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid

General procedure: A mixture ofcompound 10 (0.15 g, 0.772 mmol), HOBt (0.23 g,1.70 mmol), EDCI (0.37 g, 1.93 mmol), benzoic acid(0.19 g, 1.54 mmol), and TEA (0.32 mL, 2.32 mmol) indry DMF (20 mL) was stirred at 80 C for 8 h. The mixturewas quenched with water (40 mL), then extracted withethyl acetate (3 x 40 mL). The combined organic layerextracts were washed with brine, dried over anhydrousMgSO4, filtered, and concentrated under reduced pressure.The residue was purified by flash column chromatography.The desired product was obtained as white solid (0.13 g,56.4 %).

The synthetic route of 641571-13-3 has been constantly updated, and we look forward to future research findings.

144689-93-0, name is Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C12H20N2O3

70(a) Ethyl 1-(2′-cyanobiphenyl-4-yl)methyl-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate Following a procedure similar to that as described in Example 68(a), but using 4.01 g of ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate (prepared as described in Preparation 9), 5.0 g of 4′-bromomethylbiphenyl-2-carbonitrile and 1.97 g of potassium t-butoxide, 6.86 g of the title compound were obtained as crystals, melting at 92-93 C. Nuclear Magnetic Resonance Spectrum (CDCl3) delta ppm: 0.97 (3H, triplet, J=7.5 Hz); 1.16 (3H, triplet, J=7 Hz); 1.65 (6H, singlet); 1.74 (2H, sextet, J=7.5 Hz); 2.67 (2H, triplet, J=7.5 Hz); 4.24 (2H, quartet, J=7 Hz); 5.52 (2H, singlet); 5.77 (1H, singlet); 7.05 (2H, doublet, J=8.5 Hz); 7.42-7.67 (5H, multiplet); 7.76 (1H, doublet, J=8 Hz).

The synthetic route of 144689-93-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 2620-76-0, name is 2-(4-Bromophenyl)-1-phenyl-1H-benzoimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2620-76-0, COA of Formula: C19H13BrN2

A 500 mL four-neck round-bottomed flask (RBF) equipped with an overhead stirrer, a nitrogen inlet, a 125 mL addition funnel, and a thermocouple was purged with anhydrous nitrogen for 10 mm. The flask was charged with 2-(4-bromophenyl)-1-phenyl-1H- benzo[d]imidazole (25.0 g, 71.59 mmol) and THF (250.0 mL), and then cooled to -71°C of internal temperature. 1.6 M n-butyl lithium solution (67.0 mL, 107.2 mmol) in hexane was added dropwise into the flask via an addition funnel for 30 mm, and the mixture was further stirred at an internal temperature of -72°C of for 30 mi 2-lsopropoxy-4,4,5,5-tetramethyl- 1,3,2-dioxaborolane (32.0 mL, 171.99 mmol) was added to the resulting dark red solution via an addition funnel for 30 mm while maintaining the temperature of below -70°C. After removing a cooling bath, the brown slurry was warmed to room temperature and stirred for 16 hrs. The reactants were concentrated by using a rotary evaporator, dissolved in dichloromethane (350.0 mL), and washed with water (200.0 mL) to obtain a cloudy mixture. The aqueous layer was extracted with dichloromethane (2 X 150.0 mL), and the combined organic layers were dried with MgSO4, filtered, and concentrated by using a rotary evaporator. The resulting yellow solid was washed with hexane (100.0 mL) and tan colored solids (22.2 g) were obtained by mostly removing the color. The solids were divided into two crops and recrystallized from acetonitrile (? 180.0 mL per crop) to obtain pale orange crystalline solids as a title compound (16.5 g, 41.6 mmol, 58percent).

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