Month: May 2021

Some common heterocyclic compound, 46006-36-4, name is 1H-Benzimidazole-7-carboxylic acid, molecular formula is C8H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1H-Benzimidazole-7-carboxylic acid

Step 1: ethyl 1H-benzimidazole-4-carboxylate 2.50 g (15.4 mmol) 1H-benzimidazole-4-carboxylic acid in 100 mL ethanol are combined with 50 mL saturated ethanolic hydrochloric acid solution and refluxed for 15 hours. The reaction mixture is poured into saturated, aqueous potassium carbonate solution and extracted with ethyl acetate. The combined organic phases are dried on sodium sulphate and evaporated down to 50 mL using the rotary evaporator and filtered. 1.80 g (9.46 mmol, 61%) ethyl 1H-benzimidazole-4-carboxylate are obtained as a colourless solid. Rf=0.92 [silica gel, dichloromethane/methanol (80/20)] MS [ESI (M+H)+]]=191

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 46006-36-4, its application will become more common.

Synthetic Route of 152628-03-0, These common heterocyclic compound, 152628-03-0, name is 4-Methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 15 g of 4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid and 100 mL of sulfonyl chloride was allowed to stand at room temperature overnight, heated and stirred at an oil-bath temperature of 80C for five hours, then combined with 0.1 mL of dimethylformamide and again heated and stirred at 80C for five hours. After the sulfonyl chloride had been distilled off under reduced pressure, the residue was combined with 300 mL of dry dimethylformamide and 15 g of methylamine hydrochloride, then 40 g of triethylamine were dropped in while cooling with ice. The residue resulting from stirring at room temperature for two days, then distilling off the solvent was combined with ethyl acetate and physiological saline, and the ethyl acetate layer was separated. The ethyl acetate layer was washed with saturated physiological saline, then dried over anhydrous sodium sulfate. The residue resulting from distilling off the solvent was refined by silica gel column chromatography (elution solvent: ethyl acetate/methanol = 10/1) to give 4.4 g of the intended compound as a white solid. Mass spectrum: 232 (M+1)+.

The synthetic route of 152628-03-0 has been constantly updated, and we look forward to future research findings.

Application of 33016-47-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33016-47-6, name is 1-Trityl-1H-imidazole-4-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Under argon atmosphere, cinchonine (220 mg, 0.5 mmol) was suspended in tetrahydrofuran (absolute, 1.0 mL), and to this suspension was added a Reformatsky reagent (0.52 M; 7.7 mL, 1.51 mmol) dropwise under ice-cooling. After stirring for 10 minutes, pyridine (0.15 mL, 2 mmol) was added thereto dropwise. After stirring for 20 minutes under ice-cooling, the mixture was cooled to -40C. A solution of 4-formyl-1-trityl-1H-imidazole (0.5 mmol) in tetrahydrofuran (absolute, 2.0 mL) was added dropwise over 10 minutes, and the mixture was stirred at -40 C for 4 hours. To this reaction solution was added 1N HCl (10 mL), which was then extracted with ethyl acetate (10 mL×2). The extracted solution was washed successively with an aqueous saturated sodium bicarbonate solution and an aqueous saturated sodium chloride solution. After the organic layer was dried with sodium sulfate, the solvent was removed under reduced pressure. The residue was analyzed with high performance liquid chromatography. Consequently, the yield was 84% and the enantiomer excess was 66%.1H NMR (400 MHz, CDCl3) delta: 1.42 (9H, s), 2.74 (1H, dd, J = 16.4 and 7.8 Hz), 2.81 (1H, dd, J = 16.4 and 4.6 Hz), 3.42 (1H, d, J = 4.9 Hz), 5.06 (1H, m), 6.79 (1H, s), 7.1-7.2 (7H, m), 7.29-7.36 (8H, m), 7.37 (1H, d, J = 1.4 Hz). IR (KBr) nucm-1: 3197, 2974, 1726, 1493, 1444, 1148, 701. High Performance Liquid Chromatography Column: CHIRALPAK AD Mobile phase: Hexane/2-Propanol (90/10) Flow rate: 1.0 mL/min. Detection: UV (220 nm) Temperature: 30 C Retention Time: 22.5 minutes (enantiomer 16.8 minutes)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Trityl-1H-imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Electric Literature of 68282-53-1, These common heterocyclic compound, 68282-53-1, name is 5-Methyl-1H-imidazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

COMPOUND 12.1. 57: NV-DIETHYL-4-f 5, 6, 7-TRIMETHOXY-2-r (4-METHYL- lH-IMIDAZOL-5-YL) METHYLl-1, 2 3, 4-TETRAHYDROISOQUINOLIN-1- YL}BENZAMIDE; 4-Methyl-imidazole-5-carboxyaldehyde (65.2 mg, 0.59 mmol) was added to a solution of INTERMEDIATE 5.1. 16 (117.9 mg, 0.30 mmol) in 1,2-dichloroethane (5 mL) and the reaction mixture stirred at room temperature for 10 min. Sodium triacetoxyborohydride (439 mg, 2.07 mmol) was added followed by N-methyl-2- pyrrolidinone (350, uL) and the reaction mixture stirred at RT for 16 h. 1 N NaOH (5 mL) was added and the organic solvent removed in vacuo. The residue was extracted with EtOAc (3 x 20 mL) and the organic layer washed with water (20 mL). The organic layer was concentrated in vacuo and the residue purified by flash chromatography on Si02 column (EtOAc: MeOH 95: 5) to afford COMPOUND 12.1. 57 as an oil (32.2 mg, 22%).’HNMR (500 MHz, CDCl3) : 8 1.11 (br s, 3H), 1.25 (br s, 3H), 2. 09 (s, 3H), 2.52 (m, 1H), 2.70 (dt, J6.5, 17 Hz, 1H), 2 : 81 (dt, J4. 5, 17 Hz, 1H), 3.05 (m, 1H), 3.27 (br s, 2H), 3.39 (m, 2H), 3.55 (br s, 1H), 3.59 (m, 1H), 3.60 (s, 3H), 3.85 (s, 3H), 3.89 (s, 3H), 4.56 (s, 1H), 6.00 (s, 1H), 7.28-7. 32 (m, 4H), 7.39 (s, 1H) ; 13C NMR (125 MHz, CDC13) : 6 11. 12, 13.11, 14.41, 22.43, 39.69, 43.65, 46.30, 49.22, 56.12, 60. 71, 61.03, 67.59, 107.92, 121. 56,126. 55,129. 87, 130. 31, 132.67, 133.31, 136.29, 140.75, 145.12, 150. 85, 151. 79,171. 51; (+) LRESIMS m/z 493.24 [M+H] +.

Statistics shows that 5-Methyl-1H-imidazole-4-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 68282-53-1.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 53710-78-4

General procedure: 60% NaH (9.6mg, 0.24mmol) was added to a solution of 5a (100mg, 0.24mmol) in dry DMF (10mL) at room temperature. After stirring for 30min, 1-(3-chloropropyl)-1H-imidazole (52mg, 0.36mmol) was added and the mixture was then stirred for 5h at 80C. After cooling, the mixture was poured into cold water (200mL) and extracted with EtOAc (3×50mL). The combined organic phase was washed with brine (3×150mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/ 20 methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 64.4mg (51.0%) 6a as a red solid.

According to the analysis of related databases, 53710-78-4, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 46006-36-4, name is 1H-Benzimidazole-7-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 46006-36-4

To a solution of methyl 1H-benzo[d]imidazole-4-carboxylate (1.136 g, 7.02 mmol) in MeOH (115 mL) was added conc. H2SO4 (0.86 mL, 15.45 mmol). The reaction was heated at reflux temperature until TLC showed full conversion (24-36 hrs). The reaction was concentrated to a few mL and pH was adjusted to 8.5 with 1M K3PO3. The resulting precipitate was isolated by filtration and dried under reduced pressure to afford the title compound (0.940 g, 76%) as a white solid. mp. 211 – 213 C (Litt5. 204 C). 1H NMR (300 MHz, DMSO-d6) delta 8.31 (s, 1H), 7.95 (dd, J = 8.0, 0.9 Hz, 1H), 7.83 (dd, J = 7.6, 0.9 Hz, 1H), 7.29 (dd, J = 8.0, 7.6 Hz, 1H). 13C NMR (75 MHz, DMSO-d6) delta 165.5, 144.1, 143.6, 132.3, 124.7, 124.3, 121.0, 113.8

The synthetic route of 1H-Benzimidazole-7-carboxylic acid has been constantly updated, and we look forward to future research findings.

Electric Literature of 641571-11-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 2- (4-ethoxy-6- ( (4-methoxybenzyl) oxy) pyridin-3-yl) -4-methylpyrimidine-5-carboxylic acid (0.2 g 0.506 mmol) in 1 4-dioxane (3 mL) stirred under N2at 20 was added Et3N (0.106 mL 0.759 mmol) and DPPA (0.167 g 0.607 mmol) in one charge. The reaction mixture was stirred at rt for 30 mins. To the mixture a solution of 3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline (0.122 g 0.506 mmol) in 1 mL of 1 4-dioxane was added. The reaction solution was heated to 100 with stirring for 3 hr. The solution was concentrated in vacuo and the residue was purified by preparative TLC (DCM/MeOH 101 Rf 0.5) to yield a off white solid of 1- (2- (4-ethoxy-6- ( (4-methoxybenzyl) oxy) pyridin-3-yl) -4-methylpyrimidin-5-yl) -3- (3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl) urea (60 mg 0.095 mmol 18.7yield) 1HNMR(400 MHz CD3OD) delta9.18 (s 1H) 9.15 (s 1H) 8.39 (s 1H) 8.25 (s 1H) 8.04 (s 1H) 7.81 (s 1H) 7.54 (s 1H) 7.25-7.23 (m 2H) 6.87-6.85 (m 2H) 6.48 (s 1H) 5.31 (s 2H) 4.13-4.10 (m 2H) 3.79 (s 3H) 2.82 (s 3H) 2.59 (s 3H) 1.40-1.36 (m 3H) ES-LCMS m/z 634.2 (M+H) .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Related Products of 255064-08-5,Some common heterocyclic compound, 255064-08-5, name is 6-Bromo-1H-benzo[d]imidazole-4-carboxylic acid, molecular formula is C8H5BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 4-carboxy-6-bromobenzimidazole (3.49 g, 14.5 mmol), 3-aminomethyl-4,6-dimethylpyridin-2-one (3.32 g, 21.75 mmol,), EDCI (4.18g, 21.75mmol) and HOBT (2.94g, 21.75mmol) DMSO (15ml) N-methylmorpholine (5.87 g, 58 mmol) was quickly added to the solution. The solid slowly dissolved and allowed to react overnight at room temperature. The reaction solution was poured into ice water, stirred, allowed to stand, solid filtered, washed with water and dried to give a solid.

The synthetic route of 255064-08-5 has been constantly updated, and we look forward to future research findings.

Electric Literature of 28890-99-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

In a 250ml three-necked bottle, Under the protection of nitrogen, Add 0.01mol of raw material A-1, 0.012mol of raw material B-1, Stir and mix 150ml of toluene, Then add 0.03mol sodium tert-butoxide, 5×10-5molPd2(dba)3, 5×10-5mol tri-tert-butylphosphine, heated to 105C, refluxed for 24 hours, Sampling point plate, showing no bromide remaining, The reaction is complete; naturally cool to room temperature, filter, The filtrate was subjected to vacuum rotary evaporation (-0.09MPa, 85C), and passed through a neutral silica gel column to obtain the target product. The HPLC purity was 98.4%, and the yield was 89.2%; elemental analysis structure (molecular formula C25H16BrN3):

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1008361-65-6, name is 5-Bromo-6-methoxy-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H7BrN2O

Step 3: To a stirred mixture of DMF (3 mL) and NaH (60% in mineral oil, 67 mg, 1.6 mmol) at 0 C under argonwas added 5-bromo-6-methoxy-1H-benzo[d]imidazole (346 mg, 1.5 mmol) from Step 2 of this Example in one portion.The mixture was stirred for 5 min at 0 C. A solution of 6-(chloromethyl)-2-(methylthio)benzo[d]thiazole (500 mg, 2.2mmol) from Step 4 of Example 36 in DMF (3 mL) was added dropwise. The mixture was stirred at 0 C for 1 h, thenallowed to warm slowly to rt and stirred for 6 h. The mixture was then partitioned between EtOAc (100 mL) and water(50 mL). The EtOAc layer was separated and washed with brine, dried over Na2SO4, filtered, and concentrated underreduced pressure. The residue was purified by silica gel flash chromatography eluting with 100% EtOAc to afford thetwo regioisomers: Regioisomer 1; 6-((5-bromo-6-methoxy-1H-benzo[d]imidazol-1-yl)methyl)-2-(methylthio)benzo[d]thiazole(127 mg, 20%). The structure was confirmed by comparison with NMR from the regiospecific synthesis of thesame compound described in Step 3 of Example 41. 1H NMR (300 MHz, CDCl3) delta 8.02 (s, 1H), 7.78 – 7.91 (m, 2H),7.47 (s, 1H), 7.25 (m, 1H), 6.70 (s, 1H), 5.43 (s, 2H), 3.82 (s, 3H), 2.79 (s, 3H). LCMS (ESI) m/z 420 and 422 (M+H)+.Regioisomer 2; 6-((6-bromo-5-methoxy-1H-benzo[d]imidazol-1-yl)methyl)-2-(methylthio)benzo[d]thiazole (81 mg, 13%).1H NMR (300 MHz, CDCl3) delta 7.92 (s, 1H), 7.84 (d, J = 8.5 Hz, 1H), 7.48 (m, 2H), 7.34 (s, 1H), 7.25 (m, 1H), 5.40 (s,2H), 3.94 (s, 3H), 2.79 (s, 3H). LCMS (ESI) m/z 420 and 422 (M+H)+.

The synthetic route of 1008361-65-6 has been constantly updated, and we look forward to future research findings.