Month: May 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 73746-45-9, name is 5-Iodo-2-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 73746-45-9

EXAMPLE 11 6-(2-Methyl-1H-imidazol-4-yl)-N-phenylimidazo[1,2-a]pyridine-2-carboxamide 400 mg of 6-trimethylstannyl-N-phenylimidazo[1,2-a]pyridine-2-carboxamide (Intermediate 4), 229 mg of 2-methyl-4-iodo-1H-imidazole, 8 mL of tetrahydrofuran, 9.1 mg of bis(dibenzylideneacetone)palladium and 4.6 mg of tris(2-furyl)phosphine are placed in a microwave tube. The reaction mixture is heated for 50 minutes in a microwave machine set at 130 C. and then concentrated to dryness. The residue is taken up in 3.5 mL of N,N-dimethylformamide and a further 150 mg of 2-methyl-4-iodo-1H-imidazole, 10 mg of bis(dibenzylideneacetone)palladium and 5 mg of tris(2-furyl)phosphine are added, followed by heating again for 40 minutes in a microwave machine set at 120 C. The reaction mixture is filtered, the insoluble matter is rinsed with methanol and dichloromethane and the combined filtrates are concentrated under reduced pressure. The residue is chromatographed on a silica cartridge, eluding with dichloromethane and then with a 90/10 mixture of dichloromethane and methanol. The fractions containing the pure expected product are combined and evaporated to dryness under reduced pressure to give 28 mg of 6-(2-methyl-1H-imidazol-4-yl)-N-phenylimidazo[1,2-a]pyridine-2-carboxamide in the form of a beige-coloured solid.

The synthetic route of 73746-45-9 has been constantly updated, and we look forward to future research findings.

Reference of 13275-42-8, A common heterocyclic compound, 13275-42-8, name is 2-(2-Bromophenyl)-1H-benzo[d]imidazole, molecular formula is C13H9BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Equimolar quantity of 2-(2-bromophenyl)-1H-benzo[d] imidazole (2) and aniline derivatives in 45 ml of 1,4-dioxan was refluxed for 14 hr with continuous stirring at 80. The completion of reaction was checked by TLC. The reaction mixture was kept overnight in a refrigerator. The solvent was evaporated and a gummy solid mass was obtained. The gummy solid was then washed with cold water and recrystallized from ethanol and water (4:6) to obtain the compounds (3a-3h).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 10040-98-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10040-98-9 as follows.

The compound of formula 6-3 (methyl4-((5-(piperidin-4-yl)- I H-pyrrolo[2,3-b]pyridin- I -yl)methyl)benzoate) (0.100 g, 0.286 mmol), 4-(1H-imidazol-1-yl)benzaldehyde (0.074 g, 0.429 mmol), and sodium triacetoxyborohydride (0.09 1 g, 0.429 mmol) were dissolved in methylene chloride (3 mL) at room temperature, and the solution was stirred at the same temperature for 3 hours. Water was added to the reaction mixture, followed by extraction with methylene chloride. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried with anhydrous magnesium sulfate, filtered, and then concentrated under reduced pressure. The concentrate was purified by column chromatography (SiO 2, 12 g cartridge; methanol I methylene chloride = from 0% to 10%) to afford the desired compound of formula 12-2 (0.077 g, 52.9%) as a yellow liquid.

According to the analysis of related databases, 10040-98-9, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 1632-83-3, name is 1-Methylbenzimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1632-83-3, Quality Control of 1-Methylbenzimidazole

Under argon atmosphere, the catalyst (66 mg, 0.05 mmol, 10 mol%) and magnesium turnings (12.0 mg, 0.5 mmol) were successively added to the reaction flask.N-methylbenzimidazole (66 mg, 0.5 mmol), styrene (86 mul, 0.75 mmol), tetrahydrofuran (1.5 ml) as a solvent, reacted at 80C for 60 hours, and quenched with water, the reaction product Extract with ethyl acetate,Purification by column chromatography (developing solvent in a mixed solvent of ethyl acetate/petroleum ether at a volume ratio of 1:20) gave a yield of 87%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methylbenzimidazole, other downstream synthetic routes, hurry up and to see.

17325-26-7, name is Methyl 1H-imidazole-5-carboxylate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: imidazoles-derivatives

To a solution of methyl 1H-imidazole-4-carboxylate (14.0 g) in acetonitrile (200 mL) were added potassium carbonate (19.9 g) and potassium iodide (0.092 g), 3,4,5-trifluorobenzyl bromide (14.6 mL) was added dropwise thereto at room temperature, and then the mixture was stirred at 70C for 6 hours. The mixture was cooled to room temperature, and to the reaction mixture was added water, and then the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtrated, and then concentrated in vacuo. The resulting crude product was washed with hexane/ethyl acetate (1/2, 60 mL) to give the title compound (14.0 g). LC-MS, condition B ([M+H]+/Rt (min)): 271.4/0.725

The synthetic route of 17325-26-7 has been constantly updated, and we look forward to future research findings.

Related Products of 71759-89-2, The chemical industry reduces the impact on the environment during synthesis 71759-89-2, name is 5-Iodo-1H-imidazole, I believe this compound will play a more active role in future production and life.

4-lodo-1H-imidazole (194mg, LOmmol), phenylboronic acid (158.5 mg, 1.3mmol), potassium carbonate (345mg, 2.5mmol) and Pd (PPh3)2Cl2 (42 mg, 6%) were taken up in a degassed mixture of 1 ,4-dioxane (5mL) and water (0.8mL) under an atmosphere of nitrogen. The resulting mixture was heated at 901C for 3 hours. The reaction mixture was cooled to room temperature, and taken up in ethyl acetate and water. The organic phase was separated and the aqueous layer further extracted with 3×20 ml portions of ethyl acetate. The combined ethyl acetate layers were washed with water, brine, dried over magnesium sulfate, filtered, and concentrated under vacuum. The residue was purified by flash chromatography to give the product (112 mg) with a yield of 78%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Iodo-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Some common heterocyclic compound, 24134-09-6, name is 5-Bromo-1,2-dimethyl-1H-imidazole, molecular formula is C5H7BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: imidazoles-derivatives

General procedure: To a solution of 2-disubstituted 1-methyl-1H-imidazole 1 (1 mmol) in DMF (5 mL), NBS(169 mg, 0,95 mmol) was added and the resulting reaction mixture was stirred in the dark at room temperature for 3h. Then, Pd(PPh3)2Cl2 (14 mg, 0.02 mmol, 2 mol%), CuI (8 mg, 0.04mmol, 4 mol%), an alkyne 3 (1,1 mmol) and piperidine (300 muL, 255 mg, 3 mmol) were added and the resulting reaction mixture was stirred at 80C (when trimethylsilylacetylene was employed as the alkyne, the reaction was carried out at 50C) for 3 h. The reaction mixture was diluted with EtOAc (100 mL), then saturated aqueous NH4Cl (100 mL) was added. The resulting mixture was stirred for 30 minutes and extracted with EtOAc (3x 25mL). The organic extracts were washed with water (3 x 25 mL) and brine (1 x 25 mL), driedover anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by flash chromatogaraphy on silica gel. This procedure was employed to prepare compounds 4a-l. GLC analysis showed that all these compounds had chemical purity higherthan 98%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 24134-09-6, its application will become more common.

Some common heterocyclic compound, 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, molecular formula is C13H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 28890-99-5

c) Intermediate C-3 (2.23 g, 10.9 mmol), benzimidazolo[1,2-a]benzimidazole (2.26 g, 10.9 mmol), and potassium phosphate (2.78 g, 13.1 mmol) were suspended in NMP (66 mL). The mixture was stirred at 150 C for 48 h. After the reaction mixture was cooled at roomtemperature, 66 mL of EtCH and 244 mL of water were added there to give a solid. Thissolid was collected by filtration, and it was purifed by column chromatography on silica geleluting with a mixed solvent of heptane and CHCI3 to yield 1.74 g (4 1%) of compound 1-1as a white solid. LC-MS (mlz) 391

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 28890-99-5, its application will become more common.

Application of 10364-94-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10364-94-0 as follows.

General procedure: To a stirred solution of NaSH (9 mmol, 3 equiv.) in water (4 mL) was added N-acyl benzotriazole 1 (3 mmol, 1 equiv.). The reaction mixture was stirred at room temperature for 3 h. After completion of the reaction, HCl (2N) was added dropwise to acidify the solution. The precipitated solid was collected by vacuum filtration, washed with water (10 mL), and dried. In case of oily residue, the aqueous solution was decanted, and the residue was dissolved in EtOAc (15 mL). This solution was washed with 10% HCl (2 × 10 mL), brine (10 mL), dried over MgSO4, and concentrated under reduced pressure. These compounds are oils at room temperature but usually solidify after refrigeration.

According to the analysis of related databases, 10364-94-0, the application of this compound in the production field has become more and more popular.

Related Products of 2466-76-4, A common heterocyclic compound, 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Nucleoside/nucleotide (2; 100 mM) and N-acetyl imidazole (1a;10 equiv) were dissolved in water (pH 8; adjusted with 4 MNaOH). The solution was incubated at r.t. for 4 h, and NMR spectra were periodically acquired. The product was purified byreverse-phase (C18) flash coumn chromatography (eluted at pH4 with 100 mM NH4HCO2/MeCN = 98:2 to 80:20). The fractions containing 5 were lyophilised to yield a white powder.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.