Month: May 2021

These common heterocyclic compound, 103057-10-9, name is 4-(Chloromethyl)-1-trityl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C23H19ClN2

EXAMPLE 2 2-amino-3-[[[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]thio]propanoic acid To a stirred solution of 2.66 g (22 mmoles) of L-cysteine in 40 ml of 1N aqueous solution of sodium hydroxide (40 mmoles) at 0 C. was added a solution of 7.2 g (20 mmoles) of 4-(chloromethyl)-1-(triphenylmethyl)-1H-imidazole in 50 ml of ethanol and 20 ml of tetrahydrofuran. The temperature was allowed to rise to room temperature and the mixture was stirred for 1 hour. The solvents were evaporated under reduced pressure and the residue was taken up in 100 ml of water and 20 ml of 1N hydrochloric acid to provide a precipitate that was filtered, washed with water, filtered and dried under vacuum to provide 8 g of title compound. Melting point=162-164 C. (decomposition) Yield=90%

The synthetic route of 4-(Chloromethyl)-1-trityl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Application of 104619-51-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 104619-51-4 as follows.

Example 27: r4-(5-Amino- H .3.41 oxadiazol-2-yl)-1-oxy-pyiotadin-3-v?-(2-fluoro-4- iodo-phenvh-amine; To a solution of 3-(2-Fluoro-4-iodo-phenylamino)-1-oxy-isonicotinic acid hydrazide (150mg, 0.39mmol, 1eq) in DMSO (2mL) C- (Di-imidazol-i-yl)-methyleneamine (124mg, 0.78mmol, 2eq) was added. The reaction mixture was stirred at RT under argon overnight and then poured into water. The product was isolated by filtration (80 mg) . LC/MS (Method A) [4.68min; 414(M+1 )]

According to the analysis of related databases, 104619-51-4, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33468-69-8, name is 4-(Trifluoromethyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., Formula: C4H3F3N2

Production Example 58A mixture of 0.28 g of 2-(3-fluoropyridin-4-yl)-5-(trifluoromethyl)benzoxazole, 0.18 g of 4-(trifluoromethyl)-1H-imidazole, 0.55 g of potassium carbonate and 2 ml of DMF was stirred while heating at 50 C. for 1.5 hours. Then, the reaction mixture was cooled to room temperature. Water was added to the reaction mixture, followed by extraction with ethyl acetate twice. The combined organic layers were washed with a saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 0.40 g of 2-{3-[4-(trifluoromethyl)imidazole-1-yl]pyridin-4-yl}-5-(trifluoromethyl)benzoxazole (hereinafter, referred to as ?active compound 57?).Active Compound 571H-NMR (CDCl3) delta: 9.00 (d, J=5.2 Hz, 1H), 8.84 (s, 1H), 8.31 (d, J=5.1 Hz, 1H), 8.06-8.04 (m, 1H), 7.77-7.75 (m, 1H), 7.74-7.70 (m, 1H), 7.62 (d, J=8.6 Hz, 1H), 7.52-7.50 (m, 1H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 33468-69-8.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 360-97-4, name is 4-Amino-1H-imidazole-5-carboxamide, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Amino-1H-imidazole-5-carboxamide

A solution of delta-amino-I H-imidazole^-carboxamide (1.4 g, 11 mmol), toluene- 4-sulfonic acid 1 -(tert-butoxycarbonyl-isopropyl-amino)-propyl ester (5 g, 13 mmol) previously prepared (cf. Llauger et al., “Evaluation of 8-Arylsulfanyl, 8- Arylsulfoxyl, and 8-Arylsulfonyl Adenine Derivatives as Inhibitors of the Heat Shock Protein 90”, J. Med. Chem. 2005, vol. 48, p. 2892), and Cs2CO3 (3.6 g, 11 mmol) in 40 ml_ of DM F was stirred at 8O0C for 16 h. Removal of the solvent and purification by chromatography on silica (CHCI3/MeOH, 5%) yielded ^-(delta-Amino^-carbamoyl-imidazol-i-yO-propyll-isopropyl-carbamic acid tert-butyl ester (1.45 g, 40%) as a viscous oil . 1H-NMR [CDCI3, delta, ppm]: 7.12 (s, 1 H), 3.37 (m, 2H), 3.32 (m, 1 H), 3.07 (m, 2H), 1.92 (m, 2H), 1.40 (s, 9H), 1.07-1.06 (2s, 6H).

According to the analysis of related databases, 360-97-4, the application of this compound in the production field has become more and more popular.

Reference of 71759-87-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 71759-87-0 as follows.

To compound 62.la (0.280g, 0.866mmol, 1.Oeq) in 1,4- dioxane (5. 6mL) was added 4-iodo- 1-methyl- 1H-imidazole (0.151 g, 0.693mmo1, 0. 8eq), Cs2CO3 (0.566g, 1.73mmol, 2.Oeq). The reaction mixture was degassed for 10 mm. under argon atmosphere, then Pd2(dba)3 (0.079g, 0. l73mmol, 0. leq) and Xantphos (0. bOg, 0. l73mmol, 0.2eq) were added, again degassed for 5 mm. The reaction was stirred at 110 C for 2h. Upon completion, reaction mixture was cooled to r.t., transferred in water and product was extracted with ethyl acetate. Organic layers were combined, washed with brine, dried over Na2SO4 and concentrated in vacuo to obtain crude product. This was purified by combi flash using 2% MeOH in CH2C12 as eluantto obtain pure 62.1 (0.llOg, 47.50%). MS(ES): m/z 220.48 [M]t

According to the analysis of related databases, 71759-87-0, the application of this compound in the production field has become more and more popular.

Related Products of 68282-53-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68282-53-1 name is 5-Methyl-1H-imidazole-4-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of Apim (2.81 g, 22.5 mmol) in dry methanol (17 mL) was added 4-methyl-5-imidazolecarboxaldehyde (2.17 g, 22.5 mmol). The resulting light-yellow suspension was heated to reflux for 3 h. The suspension was dissolved completely after 5 min. The solution was then stirred overnight at room temperature. After 0.5 h the solution turned orange in colour. The solvent was removed under reduced pressure to give an orange oil, which, on standing for 3 weeks, yielded the orange solid (5) (3.10 g, yield 76 %). M.p. 113-115C. C11H15N5 (217.27): Calc. C, 60.81; H, 6.96; N, 32.23. Found: C, 60.60; H, 6.72; N, 31.35%. 1H NMR (d6-DMSO): delta=8.23 (s, 1H), 7.64 (s, 1H), 7.61 (s, 1H), 7.18 (s, 1H), 6.91 (s, 1H), 4.04 (t, 2H, J=7.2Hz), 3.42 (t, 2H, J=6.6Hz), 2.32 (s, 3H), 2.03 (p, 2H, J=6.9, 6.6Hz) ppm. 13C NMR (d6-DMSO): delta=137.2, 128.3, 119.3, 57.3, 48.5, 43.9, 32.1ppm. IR (KBr): nu=3113, 1643, 1529, 1452, 1395, 1354, 1233, 1110, 1082, 826, 747cm-1. LC/TCOF-MS: Calc. for C10H14N5 [M+1]+ 218.3. Found 218.1%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methyl-1H-imidazole-4-carbaldehyde, and friends who are interested can also refer to it.

Application of 75370-65-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 75370-65-9, name is 4-Amino-1H-benzo[d]imidazol-2(3H)-one belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Preparation of 1-(4-(trifluoromethyl)-2-(1H-1,2,4-triazol-1-yl)benzyl)-3-(2,3-dihydro-2-oxo-1H-benzo[d]imidazol-4-yl)urea Amine 2e (600 mg, 2.48 mmol) was dissolved in 20 ml of AcOEt and at 0C triphosgene (755 mg, lequiv.) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 10ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound 1a (450 mg, 3 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt 9.5 / MeOH 0.5). The solvent was evaporated and the crude was dissolved in AcOEt (30 ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 110 mg of an orange solid. Yield = 10% 1HNMR (DMSO, 200 MHz) delta 4.30 (2H, d, J = 6 Hz), 6.64 (1H, dd, J = 7.4 Hz, J’ = 1.2 Hz), 6.79 (2H, m), 6.91 (1H, dd), 7.83 (1H, d), 7.92 (2H, d), 8.33 (1H, bs), 8.42 (1H, bs), 9.07 (1H, bs), 9.94 (1H, bs), 10.59 (1H, bs); [M+1] 418.2 (C18H14F3N7O2 requires 417.34).

The synthetic route of 4-Amino-1H-benzo[d]imidazol-2(3H)-one has been constantly updated, and we look forward to future research findings.

Synthetic Route of 2963-77-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2963-77-1, name is 4-(1H-Benzo[d]imidazol-2-yl)aniline, This compound has unique chemical properties. The synthetic route is as follows.

Example 42: Preparation of 4-(1H-Benzoimidazol-2-yl)-N-[4-(1H-benzoimidazol-2-yl)- PHENYLL-BENZAMIDE (Compound 115) Following Scheme 8, 4-(LH-BENZOIMIDAZOL-2-YL)-BENZOIC acid (60 mg, 0.25 mmol) and carbonyldiimidazole (45 mg, 0.3 mmol) were stirred in DMF (1.0 ml) at 80 C under Ar for 90 minutes. To this solution was added 4-(LH-BENZOIMIDAZOL-2-YL)- PHENYLAMINE (41 mg, 0.26 mmol), and the mixture was stirred at 55 C under Ar for overnight. Water (20 ml) was added after it was cooled to ambient temperature. The solid formed was collected by filtration and was washed with water (3 X 10 ml), and ethyl ether (4 X 10 ml). Recrystallization from acetone (30 ml) gave a white solid as a pure product (20 mg, 0.047 mmol, 23%). MS m/z = 429.98 (M+H) ; 1H NMR delta 13. 11 (s, 1 H), 12.84 (s, 1 H), 10.59 (s, 1 H), 8.35 (d, J=8.4 Hz, 2 H), 8. 17 (m, 4 H), 8.01 (d, J=8.4 Hz, 2 H), 7. 83-7. 51 (m, 4 H), 7.25 (m, 4 H).

The chemical industry reduces the impact on the environment during synthesis 4-(1H-Benzo[d]imidazol-2-yl)aniline. I believe this compound will play a more active role in future production and life.

Application of 2302-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2302-25-2, name is 4-Bromo-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 1: To a stirred mixture of DMF (15 mL) and NaH (60% dispersion in mineral oil, 539 mg, 21 mmol) at 0C under argon was added 4-bromo-1H-imidazole (3 g, 20 mmol) in one portion. The mixture was stirred for 5 min at 0C. A solution of 2-(trimethylsilyl)ethoxymethyl chloride (4.3 mL, 24 mmol) in DMF (3 mL) was added dropwise. Afterstirring at 0 C for 1 h, the mixture was warmed slowly to rt and stirred for 6 h. The mixture was then partitioned betweenEtOAc (100 mL) and water (50 mL). The EtOAc layer was separated and washed with brine, dried over Na2SO4, filtered,and the filtrate was concentrated under reduced pressure. The residue was purified via silica gel flash chromatography(eluting with a gradient of 100% hexanes to 100% EtOAc) to afford a regioisomeric mixture of 4-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole and 5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole as an oil (2.9 g, 53%).LCMS (ESI) m/z 277 and 279 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 2302-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2302-25-2, name is 4-Bromo-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General Procedure 48 A mixture of 4-bromo-imidazole (217 mg, 1.48 mmol) and cesium carbonate (875 mg, 2.69 mmol) in dimethylformamide (5 mL) was stirred for 30 minutes. 4-(2-Chloro-ethyl)-morpholine hydrochloride (250 mg, 1.34 mmol) was added and the mixture was heated to 50 C. After heating overnight the reaction was concentrated by rotary evaporation. The residue was suspended in a mixture of dichloromethane and methanol and filtered. The filtrate was concentrated by rotary evaporation. The residue was purified by silica gel chromatography using gradient elution of dichloromethane, methanol to afford 4-[2-(4-Bromo-imidazol-1-yl)-ethyl]-morpholine (148 mg, 42%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1H-imidazole, other downstream synthetic routes, hurry up and to see.