Application of 288-32-4,Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Benzoyl chloride (4.99 g, 35.5mmol) wasadded dropwise to a solution of imidazole (4.83 g, 7.1mmol)in dichloromethane (25 mL). The reaction mixture wasstirred for 3 h, and the resulting precipitate was removedby filtration. The filtrate was washed with cold water (<=5 C,10mL x 3) and concentrated under reduced pressure. Theresidue was purified by bulb-to-bulb distillation (heatertemperature: 160 C, 80 mmHg) to yield 1c (4.33 g, 71%yield) as colorless liquid. 1HNMR (400 MHz, CDCl3,26 C): /ppm 8.07 (t, J = 1.0 Hz, 1H, f ), 7.817.79(m,2H, a), 7.69 (tt, J1 = 7.4 Hz, J2 = 1.8 Hz, 1H, c), 7.587.54(m, 3H, b and d), 7.16 (dd, J1 = 1.8 Hz, J2 = 1.0 Hz, 1H, e).
The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kohsaka, Yasuhiro; Homma, Kazumasa; Sugiyama, Susumu; Kimura, Yoshikazu; Chemistry Letters; vol. 47; 1; (2018); p. 100 – 102;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem