Adding a certain compound to certain chemical reactions, such as: 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 570-22-9, Safety of 1H-Imidazole-4,5-dicarboxylic acid
100 ml of methanol was added into 1H-imidazole-4,5-dicarboxylic acid (10 g, 64 mmol, 1 eq), and then the mixture was cooled to -9 C. in a low temperature cooler and added with thionyl chloride (5 to 10 eq). The mixture was then heated gradually to a reflux temperature and refluxed with stirring over-night, until it turned from a white turbid solution into a colorless transparent liquid. The solvent was then removed from the mixture by a rotary evaporator with a water pump in a water bath of 40 C. and thereby a white solid was obtained. The solid was washed with a dilute aqueous solution of sodium hydroxide and dried in an oven at 40 C. to obtain a product (dimethyl 1H-imidazole-4,5-dicarboxylate). 1HNMR (DMSO, 500 MHz): delta 8.057 (1H,s), delta 3.815 (6H,s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Imidazole-4,5-dicarboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; GUANGZHOU INSIGHTER BIOTECHNOLOGY CO.,LTD.; PENG, Xianfeng; QIN, Zonghua; (15 pag.)US2018/370921; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem