These common heterocyclic compound, 113775-47-6, name is Dexmedetomidine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C13H16N2
L- (+) – tartaric acid (9 g, 60 mmol)Was added to a solution of metomidol (12 g, 60 mmol) in ethanol (250 ml).The suspension was heated to reflux until complete dissolution,Followed by stirring at room temperature overnight,Filtration gave a white solid (9 g).The resulting solid was heated to reflux in isopropanol (200 ml)Followed by stirring at room temperature overnight,Filtration gave (13.5 g).The obtained solid was purified once more in the same manner,To obtain a solid 8. lg, purity 99.9%, yield 77.1%.
The synthetic route of Dexmedetomidine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangsu Hengrui Pharmaceutical Co; Hou, Xianshan; Wang, Junyan; Wang, Zhian; Zhong, Xinguang; (11 pag.)CN106083724; (2016); A;,
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