Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 68282-47-3, name is 2-Phenyl-1H-imidazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., Quality Control of 2-Phenyl-1H-imidazole-4-carbaldehyde
COMPOUND 12.1.63: 1-{4-[(DIETHYLAMINO)CARBONYL]PHENYL}-6- METHOXY-2-[(2-PHENYL-lH-IMIDAZOL-5-YL) METHYLl-1. 2*3. 4- TETRAHYDROISOQUINOLIN-7-YL DIMETHYLSULFAMATE; INTERMEDIATE 8.3. 1 (53 mg, 0.11 mmol) and2-phenylimidazole-4-carbaldehyde (48 mg, 0. 28 mmol) were dissolved in 1, 2-dichloroethane (5 mL) and stirred for 10 min at room temperature. Sodium triacetoxyborohydride (120 mg, 0.55 mmol) was added and the mixture was stirred for 18 h. Tosylhydrazine resin (0.37 g, 1.5 mmol/g) and DCM (5 mL) were added and the mixture was stirred for another 2 h. The resin was filtered off and washed twice with DCM. The filtrate was washed with 1 M aqueous sodium hydroxide solution, water, and brine, dried, and evaporated. Flash chromatography of the residue yielded the desired product (36 mg, 0.06 mmol, 53 %). ‘H NMR (500 MHz, DMSO): 1.02, 1.15 (2 brs, 6H), 2.72 (s, 6H), 3.04 (m, 2H), 3.18 (m, 3H), 3.40 (m, 3H), 3. 82 (s, 3H), 5. 38 (s, 1H), 6.42 (s, 1H), 7.18 (s, 1H), 7.40 (m, 4H), 7. 58 (m, 4H), 7.59 (s, 1H), 7.98 (d, J 8.0 Hz, 2H). (+) LRESIMS mlz 618 [M+H] +.
The synthetic route of 68282-47-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem