Reference of 39021-62-0, A common heterocyclic compound, 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution (0.05mol-%) of the appropriate furan-2-one (1 eq.) in dry diethyl ether (DEE) was mixed with the N-heterocyclic carbaldehyde (1, 2 or 3 eq.) under a nitrogen atmosphere at 0C. After stirring for 30min, excess dry diethylamine (4 eq.) was added dropwise. Stirring was continued for 30min. The solution was allowed to warm up over night and the product usually precipitated as fluffy powder. The precipitate was washed with cold DEE and dried in vacuo.
The synthetic route of 39021-62-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Uhrner, Fabian; Lederle, Felix; Namyslo, Jan C.; Gjikaj, Mimoza; Schmidt, Andreas; Huebner, Eike G.; Tetrahedron; vol. 73; 30; (2017); p. 4472 – 4480;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem