Research on new synthetic routes about

Synthetic Route of 2034-23-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2034-23-3 as follows.

Example 27; Prcparatiort of 5-((butyIthio)acetyl)-6-chloro-l,3-dimethyl-l,3-dihydro-2f/- benzimidazol-2-one (27); (i) 5-Chl«?>- ,3-dime-liyl-l,3-dihydr-2H-beimaiidazo.-2-onc; 5-Chloro-l ,3-dihydro-2/?-ben^imidazol-2-0Qc (7.040 g, 41.8 mmol) was dissolved in anhydrous DMF (100 ml), anhydrous potassium carbonate (34.707 g, 251 mmol) and iodomcthane (15.5 ml, 249 mmol) were added and the mixture stirred at room temperature overnight. The reaction mixture was poured into chloroform (400 ml) and mixed well then filtered and the filtrate evaporated to dryness. The resultant residue was dissolved in a mixture of ethyl acetate (500 in I) and water (200 ml), the ethyl acetate phase was washed with water (2 x 100 ml) and brine (100 ml), dried over anhydrous magnesium sulfate and filtered, The filtrate was evaporated to dryness to give the title compound (J.163 g, 87% yield) as a brown powder.1H nmr (400 MH?-, CDCIa) delta 3.37-3.42 (m, 6H); 6.87 (d, J – 8.0Hz, IH); 6.97 (d, J = 1.6Hz, IJ I); 7.07 (dd, J = 8.2, 1.8Hz, IH).

According to the analysis of related databases, 2034-23-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CORTICAL PTY LTD; WO2007/70961; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem