Reference of 616-47-7, These common heterocyclic compound, 616-47-7, name is 1-Methyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 50mL Schleck tube was added 1-methyl-1H-imidazole (4.1g, 0.05 mol), 1-iodobutane (13.8g, 0.075 mol, 1.5 equiv) and distilled toluene (20 mL), the mixture were heated and stirred at 80 C oil bath for 3 hours, after reaction, all the versitile were removed under vacuo, the residue colourless oil were washed with 2-methoxy-2-methylpropane (3×20 mL), dried under vacuo, which afforded 3-butyl-1-methyl-1H-imidazol-3-ium iodide (NHC precursor G) as colorless oil orlight yellow oil (77%, 10g).
The synthetic route of 616-47-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhou, Quan; Liu, Shu; Ma, Ming; Cui, He-Zhen; Hong, Xi; Huang, Shuang; Zhang, Jing-Fan; Hou, Xiu-Feng; Synthesis; vol. 50; 6; (2018); p. 1315 – 1322;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem